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  • Inhibitors & Agonists
    302
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
surface antigen (208-215) [Hepatitis B Virus]
T23407
The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to
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Elexacaftor
VX-445
T149352216712-66-0
Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It promotes the processing and trafficking of CFTR, increases the amount of CFTR on the cell surface, and improves the processing and trafficking of Phe508del CFTR protein.
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TargetMol | Inhibitor Hot
Datopotamab deruxtecan
S-1062a, DS-1062, DS1062, Dato-DXd
T397302238831-60-0
Datopotamab deruxtecan (DS-1062) is a trophoblast cell surface antigen 2 (TROP2)-targeted antibody-drug conjugate (ADC) with antitumor activity. Datopotamab deruxtecan induces significant antibody-dependent cellular cytotoxicity in the presence of peripheral blood lymphocytes and inhibits tumor growth in xenograft models.
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2-4 weeks
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TargetMol | Inhibitor Hot
CFTR corrector 4
T107761918142-34-3In house
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis.
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8-10weeks
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Sulfosuccinimidyl oleate
Sulfo-N-succinimidyl oleate
T13036135661-44-8In house
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long-chain fatty acid that inhibits fatty acid transport into cells. It is a potent and irreversible inhibitor of the mitochondrial respiratory chain and binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate is neuroprotective and alleviates stroke-induced neuroinflammation [1] [2].
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6-8 weeks
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OSMI-1
T164091681056-61-0In house
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.
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6-8 weeks
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Glutathione arsenoxide hydrochloride
GSAO HCl, Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)
T27417L In house
Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) is a potentially active anti-cancer molecule and inhibitor of tumour metabolism. glutathione arsenoxide hydrochloride targets the mitochondrial inner membrane adenine nucleotidyl transferase (ANT), which inhibits cell proliferation and promotes apoptosis. Glutathione arsenoxide hydrochloride can be used to recognize cell surface proteins such as protein disulfide isomerases.
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TargetMol | Inhibitor Sale
HBF-0259
HBF 0259
T27527957011-15-3In house
HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.
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6-8 weeks
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TargetMol | Inhibitor Sale
5,6-trans-Vitamin D3
5,6-trans-Colecalciferol, 5,6-trans-Cholecalciferol, Cholecalciferol EP Impurity A
T3550122350-41-0In house
5,6-trans-Vitamin D3(5,6-trans-Cholecalciferol) is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.
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7-10 days
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P53R3
T41068922150-12-7In house
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research.
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TargetMol | Inhibitor Sale
(S,S)-TAPI-1
T63390171235-71-5In house
(S,S)-TAPI-1, an isomer of TAPI-1, is a metalloproteinase (MMP) inhibitor and a TACE (ADAM17) inhibitor known for its potent inhibition of various cell surface protein shedding.
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1-2 weeks
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Cinchonine
(8R,9S)-Cinchonine, LA40221
T0012118-10-5
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
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Benzalkonium chloride
Alkyldimethylbenzylammonium chloride
T03368001-54-5
Benzalkonium chloride (Alkyldimethylbenzylammonium chloride) is a cationic surface-acting agent containing the quaternary ammonium group. It has three main categories of use: as a cationic surfactant, a biocide, and phase transfer agent in the chemical industry. This compound is a heterogeneous mixture of alkylbenzyldimethylammonium chlorides of multiple even-numbered alkyl chain lengths.
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Dibucaine
Cinchocaine
T036485-79-0
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
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Dibucaine hydrochloride
Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HCl
T0364L61-12-1
Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
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7-10 days
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Cetylpyridinium chloride monohydrate
Hexadecylpyridinium chloride monohydrate
T09006004-24-6
Cetylpyridinium chloride monohydrate (Hexadecylpyridinium chloride monohydrate) , a cationic quaternary ammonium compound, is used in certain classes of throat sprays, mouthwashes, lozenges, toothpaste, nasal sprays, and breath sprays. Cetylpyridinium chloride monohydrate has also been used as an ingredient in certain pesticides. It is an antiseptic with killing bacteria and other microorganisms. It can be potent in reducing gingivitis and preventing dental plaque. It may result in brown stains between the teeth and on the surface of teeth.
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Benzocaine
T092494-09-7
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
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Chlorhexidine
Chlorhexidinum, Nolvasan, Rotersept
T100055-56-1
Chlorhexidine (Rotersept) is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram-positive bacteria are more negatively charged, they are more sensitive to this agent.
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Beclometasone dipropionate
Beclovent, Beclomethasone dipropionate, Beconase, Vancenase
T11275534-09-8
Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.
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Tetracaine hydrochloride
Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride
T1198136-47-0
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been used for surface and spinal anesthesia.
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Gelucire 44/14
Gelucire 14 44
T19338121548-04-7
Gelucire 44 14 (Gelucire 14 44) acts as a nonionic surface-active excipient and improves fat absorption in rats with impaired lipolysis.
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1,6-Hexanedithiol
1,6-Dimercaptohexan
T2039021191-43-1
1,6-Hexanedithiol (1,6-Dimercaptohexan) is a long-chain, bifunctional alkanethiol with a serrated structure of six carbon atoms that is primarily used to form self-assembled monolayers (SAMs) to anchor surface atoms on a variety of substrates, and is also used in the synthesis of rubbers, food flavors, and reagents for organic synthesis.
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Castor oil
Xenaderm, Venelex, Ricinus Oil
T32538001-79-4
Castor oil (Xenaderm) is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis, used as a laxative and as an excipient in medicinally.
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γ-Oryzanol
Oliver, Gammariza, Gamma-Oryzanol
T360611042-64-1
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently been researched for its ability to slow the progress of melanin pigmentation by intercepting the ultraviolet rays at the skin's surface and hindering their transmission.
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