(±)-aba

Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor that effectively suppresses pathological protein aggregation, inhibiting more than 80% of aggregate formation in TTR L55P-expressing cells, Dichlorophenyl-ABA is widely employed in amyloidosis research to study TTR stabilization, aggregation mechanisms, and therapeutic intervention strategies.

8′-Hydroxy ABA (8′-OH-ABA), a key metabolite of abscisic acid (ABA), exhibits hormonal activity by promoting enhanced oil synthesis and is labile [1].

7'-Hydroxy ABA (7'-OH ABA), a metabolite of Abscisic acid (ABA), results from the hydroxylation at the 7'-carbon of ABA and demonstrates notable hormonal activity [1].

Compound 4c, also known as ABA receptor agonist 1, activates abscisic acid (ABA) receptors. It effectively inhibits seed germination and seedling growth in Arabidopsis and rice, and enhances stomatal closure and drought resistance in wheat and soybean [1].

Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.

Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.

3-Aminobenzamide (PARP-IN-1) is a potent PARP inhibitor (IC50 < 50 nM in CHO cells) and mediates oxidant-induced myocyte dysfunction during reperfusion.

Quinabactin(LC-66C6) is a potent sulfonamide abscisic acid ABA agonist.Quinabactin promotes guard cell closure, inhibits water loss, suppresses seed germination, and improves drought tolerance in adult Arabidopsis thaliana and soybean plants.

(±)-Abscisic acid is an orally active phytohormone also found in animals. It regulates blood glucose in mammals.

β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA) that predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate enables a swift release of free ABA in response to abiotic stress factors such as dehydration and salt stress, playing a crucial role in maintaining ABA homeostasis.

(±)-trans-Abscisic acid ((±)-trans-ABA) is an acid isolated from strawberry tree (Arbutus unedo L.) honeys [1].

ABA-DMNB is a caged chemical inducer of proximity (CIP) that releases active ABA (abscisic acid) upon light exposure. As a caged ABA, ABA-DMNB utilizes light to trigger the release and subsequent activity of ABA.

4-((5-amino-5-carboxypentyl)amino)benzoic acid (Standard) is a reference standard of 4-((5-amino-5-carboxypentyl)amino)benzoic acid intended for quantitative analysis, quality control, and related biochemical research applications.

4-((4-amino-4-carboxybutyl)amino)benzoic acid (Standard) is a reference standard of 4-((4-amino-4-carboxybutyl)amino)benzoic acid intended for quantitative analysis, quality control, and related biochemical research applications.

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that suppresses HDAC1 activity and induces HDAC2 degradation, exhibiting oral bioavailability. Valproic Acid activates Notch1 signalling and inhibits the proliferation of small cell lung carcinoma cells, making it applicable for research into epilepsy and bipolar disorder.

Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Broflanilide is an insecticide-resistant GABA receptor antagonist for dieldrin. Its metabolite, Desmethyl-Broflanilide, can inhibit the RDL GABAR of the striped night moth, with an IC50 value of 1.3 nM.

DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.

DSP-0565 exhibits anti-convulsant activity and good safety margin in various models including scPTZ, 6 Hz, MES, and amygdala kindling. DSP-0565 can be used in studies about acting as a broad-spectrum anti-epileptic drug.

(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist that decreases GABA-induced IP3 (inositol trisphosphate) production with an IC50 of 37.9 μM. It is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.

FG8119 is a novel benzodiazepine agonist with potential anticonvulsant and antiepileptic activity for studying neurological disorders.

Ru-32514 is a benzodiazepine receptor agonist that partially reverses stress-induced arousal in mice and is used in the study of neurological disorders.

Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound that reduces basal hsp70 mRNA expression in rat striatum and prefrontal cortex. expression in the striatum and prefrontal cortex of rats.

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.