T0039 |
Dapoxetine
|
119356-77-3
|
99.76%
|
|
Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
|
T62269 |
F 14679
|
208109-38-0
|
99.09%
|
|
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
|
T28414 |
Piclozotan
|
182415-09-4
|
99%
|
|
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) mod...
|
T4348 |
Syk Inhibitor II
|
726695-51-8
|
97.63%
|
|
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
|
T11217 |
Eplivanserin
|
130579-75-8
|
97.04%
|
|
Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.
|
T1769 |
Pardoprunox
|
269718-84-5
|
|
|
Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
|
TN1415 |
Auraptenol
|
1221-43-8
|
98%
|
|
Auraptenol possesses robust antidepressant-like efficacy in mice.
|
T15100 |
Desmethyl cariprazine
|
839712-15-1
|
98%
|
|
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
|
T17095 |
TIK-301
|
118702-11-7
|
98%
|
|
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
|
T19381 |
Isobutyryl-L-carnitine
|
25518-49-4
|
98%
|
|
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
|
T13339 |
Wf-516
|
310392-94-0
|
98%
|
|
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
|
TN4713 |
Onitisin
|
53823-03-3
|
98%
|
|
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
|
T10380 |
AS19
|
1000578-26-6
|
98%
|
|
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
|
T78228 |
4-Chloro-L-phenylalanine
|
14173-39-8
|
98%
|
|
4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis.4-Chloro-L-phenylalanine is also a non-specific antagonist of tryptophan hydroxylase (TPH1...
|
T78684 |
FFN246
|
2210244-83-8
|
98%
|
|
FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emiss...
|
T79155 |
5-HT2A receptor agonist-3
|
1391499-52-7
|
98%
|
|
5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM. It also demonstrates...
|
T79325 |
5-HT6 agonist 1
|
|
98%
|
|
Compound 19, a 5-HT6 agonist with an affinity (K i : 5 nM), exhibits antidepressant-like effects and enhances cognitive function while also inhibiting platelet a...
|
T79326 |
MRS7925
|
|
98%
|
|
MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosis [...
|
T79524 |
JPC0323
|
|
98%
|
|
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequate brai...
|
T79684 |
5-HT6R antagonist 1
|
|
98%
|
|
Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability bu...
|