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5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.
Cat. No. Product name CAS No. Purity Chemical Structure
T0039 Dapoxetine 119356-77-3 99.76%
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T3086 Mesoridazine Besylate 32672-69-8 99.27%
Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a m...
T62269 F 14679 208109-38-0 99.09%
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
T28414 Piclozotan 182415-09-4 99%
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) mod...
T4348 Syk Inhibitor II 726695-51-8 97.63%
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
T8702 SKF-83566 99295-33-7 95.00%
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
T1769 Pardoprunox 269718-84-5
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the...
TN1415 Auraptenol 1221-43-8 98%
Auraptenol possesses robust antidepressant-like efficacy in mice.
T15100 Desmethyl cariprazine 839712-15-1 98%
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T17095 TIK-301 118702-11-7 98%
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
T11949 Masupirdine mesylate 1791396-46-7 98%
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
T19381 Isobutyryl-L-carnitine 25518-49-4 98%
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T13339 Wf-516 310392-94-0 98%
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
TN4713 Onitisin 53823-03-3 98%
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
T10380 AS19 1000578-26-6 98%
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
T15026 Cyamemazine 3546-03-0 98%
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
T13021 Sulamserod 219757-90-1 98%
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
T16433 Pancopride 121650-80-4 98%
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
T12262L NPS ALX Compound 4a dihydrochloride 1781934-44-8 98%
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T10114 3-Hydroxy agomelatine 166526-99-4 98%
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
Dapoxetine
T0039
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
Mesoridazine Besylate
T3086
Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a m...
F 14679
T62269
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Piclozotan
T28414
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) mod...
Syk Inhibitor II
T4348
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
SKF-83566
T8702
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
Pardoprunox
T1769
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the...
Auraptenol
TN1415
Auraptenol possesses robust antidepressant-like efficacy in mice.
Desmethyl cariprazine
T15100
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
TIK-301
T17095
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
Masupirdine mesylate
T11949
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
Isobutyryl-L-carnitine
T19381
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
Wf-516
T13339
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
Onitisin
TN4713
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
AS19
T10380
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
Cyamemazine
T15026
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
Sulamserod
T13021
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
Pancopride
T16433
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
NPS ALX Compound 4a dihydrochloride
T12262L
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
3-Hydroxy agomelatine
T10114
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
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