Protease Activated Receptor (PAR)

Protease-Activated Receptors (PARs) are a class of G protein-coupled receptors primarily activated by binding to and being cleaved by proteases. The PAR family includes PAR1, PAR2, PAR3, and PAR4, among which PAR1, PAR3, and PAR4 are primarily activated by thrombin, while PAR2 is primarily activated by trypsin and other proteases. PARs are involved in blood coagulation, vasoconstriction, and inflammatory responses. Abnormal activation of PARs is closely associated with thrombosis, cardiovascular diseases, and tumour metastasis.