adc

DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

NH-bis(C1-Boc) is an uncleavable linker used for antibody-drug conjugates (ADC).

Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

Mal-PEG1-NHS ester is a cleavable, PEG-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs, serving as both an ADC linker and a PROTAC linker. [Mal-PEG1-NHS ester]

N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl/ether.

Fmoc-Asp-NH2 is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) is a PEG-based PROTAC linker. m-PEG12-OH can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

FMOC-3VVD-OH is an active chemical.

Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs.

DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

CL2A-SN-38 consists of a CL2A linker and an anticancer compound, SN-38, which delivers active molecules within tumor cells and in the tumor microenvironment, often in conjunction with antibodies to make biologically active antibody-coupled reactive molecules (ADCs).

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].

Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.

ADC-5 drug-linker is an ADC drug-linker conjugate (Drug-Linker Conjugates for ADC) known for its potent antitumor activity. Additionally, ADC-5 drug-linker serves a role in the synthesis of NLRP3 agonist3.

ADC 38 drug linker is a compound used for the conjugation in antibody-drug conjugates (ADCs), consisting of a CD4 mimic and a linker. It is useful for synthesizing antibody-drug conjugates such as ADC 38.

ADC-02390946 is a bioactive chemical.

ADC Control Human IgG1-vcMMAF is a human monoclonal antibody used as an isotype control for ADC human IgG1-vcMMAF, and it can inhibit tubulin polymerization. The antibody component is Human IgG1 kappa, Isotype Control, while the ADC toxic molecule and linker are composed of MC-Val-Cit-PAB-MMAF (vcMMAF).

ADC Control Human IgG1 kappa-vcMMAE is a human monoclonal antibody and an isotype control for Human IgG1 kappa-vcMMAE that inhibits tubulin polymerization.

Human IgG1 (K214R) kappa-Deruxtecan, ADC Control (DAR 4) is an IgG1-based antibody-drug conjugate control containing Deruxtecan (DXd) with an average DAR of 4. It can be used as a control in ADC.

Human IgG1 (K214R) kappa-VcMMAE, ADC Control is an IgG1-based antibody-drug conjugate control containing VcMMAE. It can be used as a control in ADC.

Human IgG1 kappa-Deruxtecan, ADC Control (DAR 4) is an IgG1-based antibody-drug conjugate control containing Deruxtecan (DXd) with an average DAR of 4. It can be used as a control in ADC.