5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.

Cat. No.	Product name	CAS No.	Purity
T0039	Dapoxetine	119356-77-3	99.76%
T0039	Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T62711	OPC-14523 hydrochloride	145969-31-9	99.70%
T62711	OPC-14523 hydrochloride (VPI 013 hydrochloride) is an orally active and potent sigma and 5-HT1A receptor agonist with antidepressant activity for the study of ne...
T17285	Zatosetron maleate	123482-23-5	99.41%
T17285	Zatosetron maleate（LY 277359 maleate） is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine.
T62269	F 14679	208109-38-0	99.09%
T62269	F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
T28414	Piclozotan	182415-09-4	99%
T28414	Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) mod...
T62107	E-3620	151213-86-4	98.88%
T62107	E-3620 is a novel 5-HT3 receptor antagonist that inhibits cisplatin-induced vomiting in beagles. E-3620 can be used to study dyskinesia, gastrointestinal dyskine...
T26691	AVN-322	1194574-68-9	98.83%
T26691	AVN-322 is an orally active and specific 5-HT6R antagonist for the study of CNS disorders such as impaired memory and schizophrenia.
T27564	Hymenidin	107019-95-4	98.05%
T27564	Hymenidin, an alkaloid isolated from the Okinawan sponge Hymeniacidon sp. is a 5-hydroxytryptaminergic receptor antagonist and voltage-gated potassium channel in...
T78228	4-Chloro-L-phenylalanine	14173-39-8	98.04%
T78228	4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis.4-Chloro-L-phenylalanine is also a non-specific antagonist of tryptophan hydroxylase (TPH1...
T12596	(4E)-SUN9221	222318-55-0	97.79%
T12596	(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertens...
T4348	Syk Inhibitor II	726695-51-8	97.63%
T4348	Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
T11217	Eplivanserin	130579-75-8	97.04%
T11217	Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.
T16433	Pancopride	121650-80-4	93.64%
T16433	Pancopride（LAS 30451） is a novel, orally available, long-acting, selective 5-HT3 receptor antagonist that blocks nitrogen mustard and dacarbazine-induced vomitin...
T16265	Naluzotan	740873-06-7	100%
T16265	Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+ c...
T1769	Pardoprunox	269718-84-5
T1769	Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
TN1415	Auraptenol	1221-43-8	98%
TN1415	Auraptenol possesses robust antidepressant-like efficacy in mice.
T15100	Desmethyl cariprazine	839712-15-1	98%
T15100	Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T17095	TIK-301	118702-11-7	98%
T17095	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
T19381	Isobutyryl-L-carnitine	25518-49-4	98%
T19381	Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T13339	Wf-516	310392-94-0	98%
T13339	Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...