e3 ligase

Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.

E3 Ligase Ligand-linker Conjugate 140 (intermediate I-11) is an E3 ubiquitin ligase ligand-linker conjugate used for synthesizing PROTACAR Degrader-6.

E3 Ligase Ligand 38 serves as the E3 ligase ligand for PROTAC IRAK4 Degrader-12, facilitating the synthesis of PROTAC.

E3ligaseLigand 29 is an E3 ubiquitin ligase ligand.

E3 Ligase Ligand-linker Conjugate 116, an E3 ubiquitinase ligand plus linker conjugate (E3 Ligase Ligand-Linker Conjugates), facilitates the synthesis of PROTAC SMARCA2 4-degrader-28.

E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM BRG1 degrader-1.

E3 Ligase Ligand 22 (compound 139) serves as a cereblon binder, facilitating the degradation of Ikaros or Aiolos via the ubiquitin proteasome pathway [1].

E3 Ligase Ligand-Linker Conjugate 34 comprises Thalidomide linked to a corresponding linker, serving as a conjugate between an E3 ligase ligand and a linker. This compound acts as a cereblon ligand, recruiting the CRBN protein and functioning as an essential intermediate in the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 7, a conjugate of E3 ligase ligand and linker, consists of Thalidomide and the corresponding Linker. It serves as a Cereblon ligand to recruit CRBN protein and is a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 149 is an E3 ubiquitin ligase ligand-linker conjugate, and it is used in the synthesis of Setidegrasib.

E3 Ligase Ligand-linker Conjugate 147 is a conjugate of an E3 ligase ligand and a PROTAC linker, utilized in the synthesis of BRD9 Degrader-1 (Compound 13-7). Comprising the E3 ligase ligand BRD9 ligand-7 and the PROTAC linker 2-((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)ethan-1-ol, this conjugate plays a critical role in biochemical applications.

E3 Ligase Ligand-linker Conjugate 148 is a conjugate used in the synthesis of PROTACs, consisting of an E3 ligase ligand and a linker.

E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugate of an E3 ligase ligand and a linker, utilized for the synthesis of the PROTAC degrader NR-11c.

E3 ligase Ligand 48 is the CRBN ligand of PROTACAR Degrader-9. PROTACAR Degrader-9 (Compound c6) functions as a PROTAC degrader targeting the androgen receptor, effectively degrading AR in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM.

E3 Ligase Ligand-linker Conjugate 157 is a compound formed from an E3 ligase ligand and a linker, utilized in the synthesis of the PROTAC degrader KT-253.

E3 Ligase Ligand-linker Conjugate 159 is a compound designed as an E3 ligase ligand-linker conjugate. It serves a role in the synthesis of SMD-3236, a PRAOTAC aimed at the targeted degradation of SMARCA2, demonstrating prolonged antitumor efficacy in vivo.

E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

E3 Ligase Ligand-linker Conjugate 114, a conjugate of an E3 ubiquitinase ligand and linker, facilitates the synthesis of PTOTAC HSD17B13 degrader 1.

E3 Ligase Ligand-linker Conjugate 118, an E3 ubiquitinase ligand plus linker conjugate (E3 Ligase Ligand-Linker Conjugates), serves as a precursor for synthesizing PROTAC SMARCA2 4-degrader-30.

E3 Ligase Ligand-linker Conjugate 126 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTACs, such as PROTAC BRM BRG1 degrader-1.

E3 Ligase Ligand-linker Conjugate 125 is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker Conjugate) used for synthesizing PROTAC IRAK4degrader-12.

E3 Ligase Ligand-linker Conjugate 120 is a conjugate comprising the E3 ubiquitin ligase ligand and linker of PROTAC PRMT3 degrader 1.