TLT8 is a ByeTAC protein degrader that targets BTK. It induces BTK degradation by non-covalently binding to Rpn-13 and BTK. TLT8 is applicable in research on chronic lymphocytic leukemia.

HDAC6degrader-6 (compound 10c) is a ByeTAC degrader specifically targeting HDAC6 and exhibits inhibitory effects on HDAC6, HDAC1, HDAC2, and HDAC3, with IC50 values noted. HDAC6degrader-6 induces apoptosis and is applicable for research in multiple myeloma.

TEC 4 is a ByeTAC (bypass E3 ligase targeting chimera) that acts as a BRD4 degrader. At a concentration of 500 nM, it results in 33% residual BRD4 in Ramos B cells. Additionally, TEC 4 exhibits toxicity in Ramos B cells with an IC50 of 30.5 nM. ByeTAC recruits proteins directly to the proteasome for degradation by interacting with Rpn-13.