g1

Aflatoxin G1 9,10-epoxide is a biochemical.

PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

Aflatoxin G1 is a mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus, which is hepatotoxic, teratogenic, immunosuppressive, and carcinogenic, and is mainly found in contaminated cereals. Aflatoxin G1 inhibits RNA polymerase activity, affects RNA and protein synthesis, and causes damage to the liver and kidney.

A2[3]G1 & A2[6]G1 glycan (G1) is a type of poly N-glycoprotein that serves as a multifunctional fluorescent linker. The resulting conjugate simulates the antennae elements of N-glycans, providing high sensitivity and specificity.

FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled, is a poly-N-glycoprotein serving as a versatile fluorescent linkage (Linker). The resulting conjugate, mimicking the antenna elements of N-glycans, exhibits high sensitivity and specificity.

A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled, is a type of poly N-glycoprotein and serves as a versatile fluorescent linker. The resulting conjugates, which mimic structural elements of N-glycan antennae, exhibit high sensitivity and specificity.

FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled, is a type of N-glycoprotein with multiple glycans and serves as a multifunctional fluorescent linker. The resulting conjugate, characterized by high sensitivity and specificity, mimics the antenna structures of N-glycans.

A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled is an N-glycan featuring two asymmetric antennary Lewis X (LeX) structures with a 2-AB (2-aminobenzamide) label. SLeX serves as a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing conjugates with SLeX polysaccharides enables targeted drug delivery to inflamed areas.

FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled is a type of polymeric N-glycoprotein that acts as a multifunctional fluorescent linker. The resulting conjugates, simulating N-glycan antenna elements, exhibit high sensitivity and specificity.

FA2[3]G1 & FA2[6]G1 glycan (G1F) is a type of poly-N-glycoprotein that serves as a multifunctional fluorescent linker. The resulting conjugate, by mimicking the arm components of N-glycans, exhibits high sensitivity and specificity.

FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled is a multifunctional fluorescent linker comprising a polymeric N-glycoprotein. The resulting conjugate simulates the antenna components of N-glycans, offering high sensitivity and specificity.

Platycoside G1 (Deapi-platycoside E) may have anti-inflammatory effects.

G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM).

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor that inhibits USP2/4/5/7/8 (EC50=7.2/3.93/8.61/6.86/4.9 μM). PR-619 induces endoplasmic reticulum stress and activates autophagy.

Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.

1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity , mediated suppression of the PKCα, MAPK and NF-κB pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity.

Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD3 with IC50 values of approximately 4.3, 3.4, 5.9, 10, and 43 μM, respectively, in an in vitro assay. Methylstat inhibits growth of the JMJD2C-sensitive esophageal cancer cell line KYSE150 with a GI50 of 5.1 μM, whereas the free acid of methylstat did not inhibit cell growth up to 100 μM. Methylstat induces histone hypermethylation at multiple sites in a concentration-dependent manner (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 μM in KYSE150 cells and 6.7 ad 6.3 μM in MCF-7 cells, respectively).

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1.

Prostaglandin G1 is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Monamycin G1 is an ester-peptide antibiotic [esterpeptid]. It shows activity against Gram-positive bacteria.

Luminacin G1 exhibits a potent inhibitory effect on capillary formation, with an IC50 of less than 0.1 μg/mL.