1a1

1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1 (IC50 = 0.18 μM), 1A2 (IC50 = 0.32 μM), and 2B1 (IC50 = 0.04 μM).

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) is Elongation factor 1 subunit.eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in the brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in the brain, heart, and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes1.

7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.

ALDH1A1-IN-5 (compound 25) is a potent inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), exhibiting EC50 values of 83 µM, 45 µM, and 43 µM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. This compound holds potential for research in high-grade serous ovarian cancer (HGSOC).

CYP1A1-IN-1 (Compound 47) is a small molecule inhibitor of cytochrome P450 1A1 (CYP1A1). It reduces the bacterial load of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 shows potential for research in sepsis caused by multi-drug resistant (MDR) bacteria.

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed

CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxicity.

ALDH1A1-IN-2 is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with anticancer activity and may be used in research on breast cancer, inflammation, or obesity.

ALDH1A1-IN-3 is a good and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50: μM).ALDH1A1-IN-3 is effective in improving glucose consumption in HepG2 cells.ALDH1A1-IN-3 can be used for studies to improve glucose metabolism.

UGT1A1-IN-1 (Compound 2) is a non-competitive inhibitor of UGT1A1 (UDP-glucuronosyltransferase 1A1). It inhibits the 1-O-glucuronidation process mediated by UGT1A1 with an IC50 of 1.33 μM and a Ki value of 5.02 μM. UGT1A1-IN-1 binds to UGT1A1 at the same ligand-binding site as Bilirubin. Additionally, it displays favorable reactivity in human liver microsomes (HLM) and serves as a practical, high-affinity fluorescent probe substrate for UGT1A1, facilitating the study of bilirubin metabolism disorders and enzyme activity.

H1L1A1B3, an ionizable cationic lipid, is commonly used alongside other lipids to create lipid nanoparticles (LNPs) designed for the delivery of circular RNA (circRNA) both in vitro and in vivo.

SLC1A1/EAAT3-IN-1 (Compound 3e) is a selective EAAT3 inhibitor with an IC50 of 7.2 μM for hEAAT3, while its IC50 values for EAAT1, EAAT2, and EAAT4 are approximately 250 μM. It is utilized in research related to psychiatric disorders such as obsessive-compulsive disorder and schizophrenia.

The ATP1A1 Human Pre-designed siRNA Set A consists of three pairs of siRNA designed for various regions of the ATP1A1 (Human) gene. This set also includes a negative control, a FAM-labeled negative control, and a positive control.

CYP11A1-IN-2 (Compound 61) is a selective inhibitor of cholesterol side-chain cleavage enzyme (CYP11A1). This compound has the ability to inhibit steroid biosynthesis and may be utilized in research on steroid hormone-dependent cancers, such as prostate cancer.

ALDH1A1 modulator-1 is an agent that modulates ALDH1A1.

CYP11A1-IN-3 (Compound II-4) is a selective inhibitor of CYP11A1, with an IC50 value of 26.7 nM. It demonstrates selectivity towards CYP1A2, 2C9, and 2D6 as well. This compound is useful for research in castration-resistant prostate cancer.

CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1].

CYP11A1-IN-1 (compound 30) is a selective CYP11A1 enzyme inhibitor with an IC50 of 201-2000 nM, used for studying steroid receptor-mediated diseases, particularly targeting androgen receptors in conditions like prostate cancer [1].

ALDH1A1-IN-4 (compound A1) functions as a powerful inhibitor of aldehyde dehydrogenase (ALDH) A1, exhibiting an IC 50 value of 0.32 μM. This compound is significant in cancer research [1].

Anti-Mouse PD-1 Antibody (29F.1A12), a rat-derived ntibody targeting PD-1, can specifically block the binding of PD-1 to its ligands PD-L1 and PD-L2. Based on this mechanism of action, it is widely applicable to research in cancer and immunology, including studies on the CT26 tumor model and pancreatic cancer research. Its isotype control is Rat IgG2a kappa Isotype Control.

Anti-Mouse PD-1/CD279 (D265A) Antibody (29F.1A12) is a rat-derived inhibitory antibody that targets mouse PD-1 and blocks its binding to both PD-L1 and PD-L2 ligands.It is suitable for cancer and immunology research, including CT26 tumors and pancreatic cancer models .

Anti-Mouse IL-2 Antibody (JES6-1A12) is a monoclonal inhibitory antibody against mouse IL-2. It inhibits Treg cell expansion, enhances Th1 response, and forms complexes with IL-2, mostly used in research on infectious diseases such as malaria.

BAY-218 is an aryl hydrocarbon receptor (AHR) antagonist with IC50 of 39.9 nM in the human glioblastoma U87 cell line. BAY-218 inhibition of AhR stimulates pro-inflammatory monocyte and T cell responses in vitro and drives anti-tumor immune responses, leading to reduced tumor growth in vivo.

EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.