g3

G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

G3-C12 TFA Salt is a specific galectin-3 binding peptide with Ksubdsub of 88 nM and shows anticancer activity.

G3335 Acetate was discovered to be a novel PPARgamma antagonist.

RG33 Peptide, utilized in type 2 diabetes (T2D) research [1], enhances glucose clearance in insulin-resistant mice and facilitates cholesterol efflux in cultured macrophages by effectively solubilizing lipid vesicles.

DPLG3, a specific inhibitor of the chymotryptic-like β5i subunits, effectively inhibits mouse i-20S proteasomes with an IC50 value of 9.4 nM. This compound has applications in the research of immune diseases [1].

RG33, a synthetic 33-amino acid peptide, matches the sequence of amino acids 209-219 and 220-241 found in the C-terminal domain class Y helices of apolipoprotein A1 (ApoA1). This compound has the ability to solubilize multilamellar vesicles (MLVs) containing 1,2-dimyristoyl-sn-glycero-3-PC (DMPC), resulting in the formation of recombinant HDL. When bound to lipids, RG33 facilitates cholesterol efflux in J774 macrophages and has been shown to reduce blood glucose levels in insulin-resistant mice at a dosage of 12 mg/kg.

RP-182-PEG3-K(palmitic acid) (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. It inhibits CD206highM2-like macrophages with an IC50 of 3.2 μM and induces phagocytosis. Additionally, RP-182-PEG3-K(palmitic acid) TFA demonstrates antitumor activity in murine B16 melanoma allografts.

APTAA-LHRH is a gonadorelin antagonist.

WAAG-3R is a bioactive peptide utilized in an ADAMTS-4 (Aggrecanase-1) assay, where aggrecanases, a subset of the ADAMTS (A disintegrin and metalloprotease with thrombospondin motifs) family, target aggrecan, a key structural component of cartilage. Notably, ADAMTS-4 is a principal aggrecanase in human osteoarthritic cartilage. The peptide's fluorescence resonance energy transfer (FRET) properties are evidenced by an excitation/emission (Ex/Em) spectrum of 340/420 nm.

Veldoreotide, also known as Somatoprim, is a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue which effectively reduces GH secretion in human GH-secreting pituitary adenomas, even in Octreotide non-responsive tumours.

Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].

LAG-3cyclic peptide inhibitor C25 is an inhibitor of LAG-3. It demonstrates a high affinity for human LAG-3 protein with a dissociation constant (Kd) of 0.66 μM. This compound can block the interaction between LAG-3 and HLA-DR (MHC-II), thereby activating CD8+ T cells. LAG-3cyclic peptide inhibitor C25 is applicable in tumor research.

LAG-3cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3, exhibiting an IC50 of 4.45 μM and a Ki of 2.66 µM.