ptio

PTIO, a specific scavenger of NO, reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be utilized to examine nitric oxide synthase inhibitory activity.

Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.

Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.

cholesterol-absorption inhibitor Intermediate 2 is a potent and orally active cholesterol absorption inhibitor that reduces blood cholesterol levels.

NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.

Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a 14-amino acid peptide coactivator, encompassing residues 740-753 of the TIF-2 protein.

Transcription factor-IN-1 (Compound 4e) acts as an inhibitor of transcription factors. It exhibits anticonvulsant activity by antagonizing pentylenetetrazole (PTZ) with an ED50 of 34.5 mg kg. Additionally, Transcription factor-IN-1 demonstrates antidepressant activity in a rat model.

The signal transducer and activator of transcription 6 fragments is a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3.