ptio

PTIO, a specific scavenger of NO, reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be utilized to examine nitric oxide synthase inhibitory activity.

Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.

Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.

cholesterol-absorption inhibitor Intermediate 2 is a potent and orally active cholesterol absorption inhibitor that reduces blood cholesterol levels.

NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.

MET Transcription-IN-1 (Compound C3) is an orally active inhibitor of MET transcription that efficiently binds to and stabilizes the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. It can overcome resistance caused by specific c-Met mutations and effectively inhibits tumor cell proliferation, migration, and invasion, inducing cell cycle arrest and apoptosis. This compound exhibits antitumor activity and is applicable in the study of tumors such as non-small cell lung cancer.

Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a 14-amino acid peptide coactivator, encompassing residues 740-753 of the TIF-2 protein.

Transcription factor-IN-1 (Compound 4e) acts as an inhibitor of transcription factors. It exhibits anticonvulsant activity by antagonizing pentylenetetrazole (PTZ) with an ED50 of 34.5 mg/kg. Additionally, Transcription factor-IN-1 demonstrates antidepressant activity in a rat model.

The signal transducer and activator of transcription 6 fragments is a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3.