omi

Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity or by a BIRC inhibition-independent, caspase-independent, and serine protease activity-dependent mechanism. HTRA2 cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 of HTRA2 seems to be proteolytically inactive. Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) which is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa.

Expression system: P. pastoris (Yeast)
Length: 721-1055, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1566-1837, Partial
Activity: Not Tested

Expression system: HEK293
Length: 2-409, Full Length of Mature Protein
Activity: Not Tested

Blo t 12 Protein, Blomia tropicalis, Recombinant (His) is expressed in E. coli. The accession number is Q17282.

The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.70 kDa and the accession number is A0A6G7K2L4.

Expression system: HEK293 Cells
Length: 14-683 (mutation), Partial
Activity: ELISA

Influenza A H3N2 (A Wyoming 03 2003) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is B2XWY0.

HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3 NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. One of the HCV proteases, NS3-4A serine protease, is a non-covalent heterodimer consisting of a catalytic subunit (the N-terminal one-third of NS3 protein) and an activating cofactor (NS4A protein) and is responsible for cleavage at four sites of the HCV polyprotein.

Influenza A H3N2 (A Wyoming 03 2003) Hemagglutinin Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is B2XWY0.

Blo t 1 Protein, Blomia tropicalis, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 37.7 kDa and the accession number is A1KXI0.

Blo t 2 Protein, Blomia tropicalis, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q1M2P1.

Blo t 5 Protein, Blomia tropicalis, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is O96870.1.

Blo t 21 Protein, Blomia tropicalis, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.2 kDa and the accession number is A7IZE9.

SARS-CoV-2 BA.2.86 (Omicron) Spike RBD Protein (aa 319-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.36 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 EG.5.1 (Omicron) Spike S1+S2 trimer Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 136.29 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 (Omicron) Spike S1+S2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 134.54 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 sublineage BA.2 (Omicron) Spike RBD Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.71 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 (Omicron) S1+S2 trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 138.48 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 BA.4.6 BF.7 (Omicron) Spike RBD Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.62 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 BA.2.75.2 (Omicron) Spike S1+S2 trimer Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 136.41 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 (Omicron) Spike S1 NTD Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.68 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 (Omicron) Spike RBD Protein (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.78 kDa and the accession number is YP_009724390.1.

SARS-CoV-2 B.1.1.529 (Omicron) Spike RBD Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.83 kDa and the accession number is YP_009724390.1.