oxygen

Uric acid is an important antioxidant that scavenges oxygen radicals and reactive oxygen species (such as singlet oxygen and peroxynitrite), inhibits lipid peroxidation, helps maintain stable blood pressure, and is the final product of purine metabolism. It is commonly used to induce hypertension models.

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.

Ensulizole is a sulfonated ultraviolet absorber that strongly absorbs UVB and some UVA, and under UV or sunlight exposure, it produces reactive oxygen species that can damage DNA.

Buprofezin (Applaud) is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.

EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities and inhibits the formation of β-amyloid and related amyloid fibrils.

Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.

Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.

Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.

Heme Oxygenase-1-IN-1 (HO-1-IN-1) is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).

Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.

5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.

HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).

8-Hydroxygenistein (8-OHG) is an antioxidant that effectively scavenges NO and O2-. It is a type of ortho-dihydroxyisoflavone (ODI) and is abundantly found in thick and fermented soy sauces, exhibiting stronger antioxidant properties than its parent compound, Genistein. The concentration of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r=0.959) and maintains high stability even after being heated in boiling water for 60 minutes. It is effective in preventing oxidative damage during the brewing and storage of soy sauce, offering potential applications in food antioxidant research.

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .

1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.

Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective inhibitor of heme oxygenase-2 (HO-2), with IC50 values of 14.9 μM for HO-1 and 0.9 μM for HO-2 [1].

Heme Oxygenase-1-IN-2, a novel inhibitor of heme oxygenase-1 (HO-1), demonstrates potent antiproliferative activity in vitro with an IC50 value of 0.95 μM.

5-Lipoxygenase-IN-3 (Compound 14), with an IC50 of less than 1 μM, serves as an inhibitor of 5-Lipoxygenase. This compound is utilized in the research of inflammatory diseases, cancer, stroke, and Alzheimer's disease [1].

Heme Oxygenase-1-IN-3 (compound 4) serves as a potent and selective inhibitor of heme oxygenase-1 (HO-1) with a dissociation constant (Kd) of 141 nM, making it suitable for use in cancer and neurodegenerative disease research.

2'-Hydroxygenistein (Standard) is a reference standard for research and analysis in studies involving 2'-Hydroxygenistein. 2'-Hydroxygenistein is a naturally occurring flavonoid with a wide range of antioxidant, anti-inflammatory, anticancer, and anti-endometrial hyperplasia potentials.2'-Hydroxygenistein is a inhibitor of a variety of enzymes, including indole-3-acetic acid oxidase, α-glucosidase, β-glucuronidase, and lysozyme.

Hydroxygenkwanin (Standard) is a reference standard for research and analysis in studies involving Hydroxygenkwanin. 1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.

1-Deamino-1-hydroxygentamicin C1a (AntibioticSU-2) is an aminoglycoside antibiotic effective against both gram-positive and gram-negative bacteria.

2-Hydroxygentamicin C2 is an aminoglycoside antibiotic that exhibits activity against both Gram-positive and Gram-negative bacteria.

1-Deamino-1-hydroxygentamicin C2 (AntibioticSU-1) is an aminoglycoside antibiotic effective against both Gram-positive and Gram-negative bacteria.