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N-Acetyl-D-cysteine

Name: N-Acetyl-D-cysteine
Brand: TargetMol
SKU: T38155
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38155Cas No. 26117-28-2

N-Acetyl-D-cysteine exhibits antioxidant activities and scavenges ROS through its thiol group reaction.

N-Acetyl-D-cysteine

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Purity: 99.71%

Catalog No. T38155Cas No. 26117-28-2

N-Acetyl-D-cysteine exhibits antioxidant activities and scavenges ROS through its thiol group reaction.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$72	In Stock	In Stock
100 mg	$122	In Stock	In Stock
200 mg	$178	In Stock	In Stock
500 mg	$297	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

N-Acetyl-D-cysteine exhibits antioxidant activities and scavenges ROS through its thiol group reaction.

In vitro

Consistent with the known stereoselectivity of many biological processes, the unnatural D isomer of N-acetylcysteine failed to increase hepatic glutathione. Liver concentrations remained similar to control suggesting that the D isomer was unable to increase the rate of glutathione synthesis. The D isomer further differed from its L enantiomer in failing to increase the plasma concentration and the urinary excretion of inorganic sulfate. Congruent with these observations, much more N-acetyl-D-cysteine (47% of dose) was recovered unchanged in 24 hr urine than N-acetyl-L-cysteine (6.1% of dose)[2].

Chemical Properties

Molecular Weight	163.19
Formula	C₅H₉NO₃S
Cas No.	26117-28-2
Smiles	CC(=O)N[C@H](CS)C(O)=O
Relative Density.	1.294g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 122.5 mg/mL (750.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.1278 mL	30.6391 mL	61.2783 mL	306.3913 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL	61.2783 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL	30.6391 mL
20 mM	0.3064 mL	1.5320 mL	3.0639 mL	15.3196 mL
50 mM	0.1226 mL	0.6128 mL	1.2256 mL	6.1278 mL
100 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc