d5

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.

Aniline-d5 is a deuterated isotope marker of Aniline, which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.

Ketorolac D5, a deuterium-labeled version of Ketorolac, is a non-steroidal anti-inflammatory agent that functions as a nonselective COX inhibitor. It exhibits IC50 values of 20 nM for COX-1 and 120 nM for COX-2.

Piperacillin-d5 is a deuterated compound of Piperacillin. Piperacillin has a CAS number of 61477-96-1. Piperacillin is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains)

Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.

(R)-Finerenone-d5 is a deuterated compound of (R)-Finerenone. (R)-Finerenone has a CAS number of 1050477-30-9.

Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and HIF-2α in Hep3B hepatocellular carcinoma cells. It increases levels of secreted erythropoietin in Hep3B cells in a concentration-dependent manner and increases erythropoiesis in rats when administered at doses of 25 and 50 mg kg. Roxadustat reverses anemia in a rat model of chronic inflammation induced by peptidoglycan-polysaccharide, as well as a rat model of chronic kidney disease induced by 5 6 nephrectomy. It reduces tumor growth and increases survival in a murine Lewis lung carcin......

Ketorolac-d5-P1 is a deuterated compound of Ketorolac. Ketorolac has a CAS number of 74103-06-3. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.

Ketorolac-d5-P2 is a deuterated compound of Ketorolac. Ketorolac has a CAS number of 74103-06-3. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.

Irinotecan Impurity 52-d5 is a deuterated compound of Irinotecan Impurity 52.Irinotecan Impurity 52 has a CAS number of 1026078-50-1.

(S)-Pramipexole-(N-Propyl-2,2,3,3,3-d5) Dihydrochloride is a deuterated compound of (S)-Pramipexole Dihydrochloride. (S)-Pramipexole Dihydrochloride has a CAS number of 104632-25-9. Pramipexole dihydrochloride could be used to treat Parkinson disease.

Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells. Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg kg. Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.

Decoquinate-d5 is a deuterated compound of Decoquinate. Decoquinate has a CAS number of 18507-89-6. Decoquinate is a coccidiostat for poultry.

Taurolithocholic Acid-d5 Sodium Salt (Major) is a deuterated compound of Taurolithocholic Acid Sodium Salt. Taurolithocholic Acid Sodium Salt has a CAS number of 6042-32-6. The major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.

Propafenone-d5 HCl is a deuterated compound of Propafenone HCl. Propafenone HCl has a CAS number of 34183-22-7. Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

ortho-Hydroxy Atorvastatin-d5 Calcium Salt is a deuterated compound of ortho-Hydroxy Atorvastatin Calcium Salt. ortho-Hydroxy Atorvastatin Calcium Salt has a CAS number of 265989-47-7.

Terbutryn-d5 (ethyl-d5) is a deuterated compound of Terbutryn. Terbutryn has a CAS number of 886-50-0. Terbutryn is a selective herbicide and a triazine compound. It acts as an inhibitor of photosynthesis.

1,3-Distearoyl-2-chloropropanediol-d5 is a deuterated compound of 1,3-Distearoyl-2-chloropropanediol.

3-phenylpropionic acid-d5 is a deuterated compound of 3-phenylpropionic acid.

Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer). It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg ml, reduces cough induced by citric aci......

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.

Dxd-d5, a deuterated derivative of Dxd, acts as a potent DNAtopoisomerase I inhibitor with an IC50 value of 0.31 μM. It serves as the effective payload for the antibody-drug conjugate (ADC) targeting HER2, known as DS-8201a.

Midostaurin-D5 is a deuterium labeled Midostaurin.

Reboxetine-d5 Mesylate is a deuterated compound of Reboxetine Mesylate. Reboxetine Mesylate has a CAS number of 98769-84-7. Reboxetine is a norepinephrine reuptake inhibitor (Ki: 8.2 nM).