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PSMA-D5

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Catalog No. T203023Cas No. 3056440-83-3

PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).

PSMA-D5
Other Forms of PSMA-D5:

PSMA-D5

😃Good
Catalog No. T203023Cas No. 3056440-83-3
PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).
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Product Introduction

Bioactivity
Description
PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).
In vitro
PSMA-D5 ([68 Ga] labeled) demonstrates excellent uptake performance in PSMA-positive 22Rv1 cells, with an uptake value of 1.68.
In vivo
PSMA-D5 ([68 Ga] labeled), administered at approximately 3.7 MBq via intravenous injection, exhibits a high tumor uptake in 22Rv1 tumors (SUV max = 3.51). Compared to PSMA-11 ([68 Ga] labeled), it demonstrates improved visualization of smaller lesions, with T/M values of 32.01 and 26.8, respectively.
Chemical Properties
Molecular Weight1317.31
FormulaC57H80N12O24
Cas No.3056440-83-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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