compound 3

POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.

(1R,3S)-Compound E is an isomer of Compound E and can be used as a control compound in experiments. It serves as a γ-secretase inhibitor. The IC50 values of Compound E for inhibiting β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage are 0.24, 0.37, and 0.32 nM, respectively.

New compound 3 can be used for related research in the field of life sciences, and its product number is TN6410.

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

2-(Diphenylphosphino)pyridine ,with CAS No. 37943-90-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(Diphenylphosphino)pyridine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(2-Methoxyphenyl)piperazine ,with CAS No. 35386-24-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(2-Methoxyphenyl)piperazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Nrf2 degrader 30 is a small molecule PROTAC that inhibits the degradation of Nrf2, thereby enhancing its activity. Nrf2 is a key transcription factor that regulates cellular antioxidant responses and various protective mechanisms. The activity of Nrf2 is primarily regulated by its interaction with Keap1, which serves as an E3 ubiquitin ligase complex adapter to promote Nrf2 ubiquitination and proteasomal degradation。

1-[4-(4-Fluorophenoxy)phenyl]ethanone ,with CAS No. 35114-93-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-[4-(4-Fluorophenoxy)phenyl]ethanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Fluoro-1H-indole-3-carboxylic acid methyl ester ,with CAS No. 310886-79-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Fluoro-1H-indole-3-carboxylic acid methyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ethyl 5-fluoroindole-2-carboxylate ,with CAS No. 348-36-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Ethyl 5-fluoroindole-2-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Methylbenzothiophene-2-carboxylic acid ,with CAS No. 3133-78-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Methylbenzothiophene-2-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-(4-Methylphenyl)isoxazole-3-carboxylic acid ,with CAS No. 33282-21-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-(4-Methylphenyl)isoxazole-3-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-(Trifluoromethyl)quinoline ,with CAS No. 325-14-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-(Trifluoromethyl)quinoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Hydroxyphthalazine-1-carboxylic acid ,with CAS No. 3260-44-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Hydroxyphthalazine-1-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(4-Methoxy-phenyl)-1H-pyrazole ,with CAS No. 35715-67-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(4-Methoxy-phenyl)-1H-pyrazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one ,with CAS No. 37949-03-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Fluoro-1H-benzimidazole-2-amine ,with CAS No. 30486-73-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Fluoro-1H-benzimidazole-2-amine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Bromoisoindolin-1-one ,with CAS No. 337536-15-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Bromoisoindolin-1-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,2,3-Benzoxadiazole-5-carbaldehyde ,with CAS No. 32863-33-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,2,3-Benzoxadiazole-5-carbaldehyde provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-(Phenylmethoxy)-1H-indazole ,with CAS No. 351210-09-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-(Phenylmethoxy)-1H-indazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Bromoquinoxaline ,with CAS No. 36856-91-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Bromoquinoxaline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Hydroxy-6-iodoquinoline ,with CAS No. 342617-07-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Hydroxy-6-iodoquinoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-(Boc-amino)phthalimide ,with CAS No. 34387-89-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-(Boc-amino)phthalimide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.