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PDE5-IN-13

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Catalog No. T204706

PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM and is applicable in pulmonary arterial hypertension research. It demonstrates high selectivity for its target compared to PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11, and it possesses oral bioavailability.

PDE5-IN-13

PDE5-IN-13

😃Good
Catalog No. T204706
PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM and is applicable in pulmonary arterial hypertension research. It demonstrates high selectivity for its target compared to PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11, and it possesses oral bioavailability.
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Product Introduction

Bioactivity
Description
PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM and is applicable in pulmonary arterial hypertension research. It demonstrates high selectivity for its target compared to PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11, and it possesses oral bioavailability.
Targets&IC50
PDE11A:>100000 nM
In vitro
PDE5-IN-13's C3 cyanide group forms hydrogen bonds with D76 and H613 through a water molecule, thereby stabilizing the binding conformation of PDE5-IN-13 [1].
In vivo
PDE5-IN-13 (1500 mg/kg, p.o.) shows no acute toxicity in mice [1]. In a rat model of Monocrotalin-induced pulmonary arterial hypertension, PDE5-IN-13 (5.0 mg/kg, p.o., daily for 21 days) is significantly more effective than Sildenafil citrate (10.0 mg/kg) at increasing mPAP (mean pulmonary artery pressure) and reducing RVHI (right ventricular hypertrophy index).
Chemical Properties
Molecular Weight486.564
FormulaC31H26N4O2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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