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PDE5-IN-13

Name: PDE5-IN-13
Brand: TargetMol
SKU: T204706
Rating: 4.5 (1 reviews)

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Catalog No. T204706

PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM and is applicable in pulmonary arterial hypertension research. It demonstrates high selectivity for its target compared to PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11, and it possesses oral bioavailability.

PDE5-IN-13

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Catalog No. T204706

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Product Introduction

Bioactivity

Description	PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM and is applicable in pulmonary arterial hypertension research. It demonstrates high selectivity for its target compared to PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11, and it possesses oral bioavailability.
Targets&IC50	PDE11A:>100000 nM
In vitro	PDE5-IN-13's C3 cyanide group forms hydrogen bonds with D76 and H613 through a water molecule, thereby stabilizing the binding conformation of PDE5-IN-13 [1].
In vivo	PDE5-IN-13 (1500 mg/kg, p.o.) shows no acute toxicity in mice [1]. In a rat model of Monocrotalin-induced pulmonary arterial hypertension, PDE5-IN-13 (5.0 mg/kg, p.o., daily for 21 days) is significantly more effective than Sildenafil citrate (10.0 mg/kg) at increasing mPAP (mean pulmonary artery pressure) and reducing RVHI (right ventricular hypertrophy index).

Chemical Properties

Molecular Weight	486.564
Formula	C₃₁H₂₆N₄O₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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