tn 1

TN1 is a potent inducer of fetal hemoglobin (HbF).

HRSV HMPV-IN-1 (compound 3) is an inhibitor targeting HRSV HMPV, exhibiting EC50 values of < 0.2 μM against human RSV-A and < 0.5 μM for human MPV A2 TN 94-49. This compound is utilized in the study of bronchiolitis and pneumonia.

TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.

FMOC-L-THR (AZP-531) is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser Thr (Tn +antigen)[1].

Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

Tubulin NRP1-IN-1 (compound TN-2) serves as a dual inhibitor targeting both Tubulin and NRP1, exhibiting IC50 values of 0.71 μM and 0.85 μM, respectively. This compound notably reduces the viability of prostate tumor cell lines and triggers apoptosis [1].

Azadirachtin (Standard) is the standard substance of Azadirachtin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Azadirachtin has antifungal activity, used as an insecticide.

Azadirachtin has antifungal activity, used as an insecticide.

Gynosaponin TN-2, demonstrating anti-Parkinsonian activity, mitigates L-DOPA (100 and 200 μM)-induced apoptotic cell death in pheochromocytoma 12 cells through the modulation of extracellular signal-regulated protein kinases 1 and 2 activation.

O-GlyCORTAR protease, recombinantly expressed from E.coli and tagged with His, is an enzyme that relies on O-glycans to cleave proteins carrying mucin-type O-glycans, including sialylated substrates and glycosylated Serine and Threonine residues at the N-terminus. This protease can process various O-glycan structures, such as sialylated core 1 and core 2 configurations, as well as the Tn antigen. Notably, O-GlyCORTAR protease does not cleave terminally modified serine or threonine residues, nor does it act on N-glycosylation sites of glycoproteins.

α-N-acetylgalactosidase (EC 3.2.1.4) is a highly specific exoglycosidase capable of effectively hydrolyzing α-N-acetylgalactosamine (GalNAc) linked to serine or threonine residues in glycoproteins (Tn antigen). This enzyme demonstrates activity towards terminal GalNAc in α 1-3 linkages and operates optimally within a pH range of 6.0-7.6, without requiring cofactors or specialized buffer systems.