necrosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
T6S0630	Hypaconitine		P450 , TNF
	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.		P450 , TNF
T39849	Propargite		Parasite
	Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 μM [1] .		Parasite
T4319	Hispidol	(Z)-Hispidol	TNF
	Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.		TNF
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
T14848	C 87		Others , TNF
	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.		Others , TNF
T4S0217	HOMOPLANTAGININ		TNF , NF-κB
	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza.		TNF , NF-κB
T11991	Mefentrifluconazole		P450 , Antifungal
	Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ...		P450 , Antifungal
T6S0627	Mesaconitine		TNF
	1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.		TNF
T11096	DRI-C21045		NF-κB
	Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L...		NF-κB
T9921	Infliximab		TNF
	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.		TNF
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
T2879	Fisetin		TNF , Sirtuin , PPAR
	Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.		TNF , Sirtuin , PPAR
T2065	Bioymifi	DR5 Activator	Apoptosis , TNF
	Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.		Apoptosis , TNF
T13951	UCB-9260		TNF
	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.		TNF
T4S0227	Sinensetin	Pedalitin permethyl ether	TNF , PGE Synthase
	Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.		TNF , PGE Synthase
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
T12997	SR-318		p38 MAPK , TNF
	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity.		p38 MAPK , TNF
T7001	TIC10	ONC-201	Apoptosis , TNF
	TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.		Apoptosis , TNF
T6649	(S)-(+)-Rolipram	(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram	Apoptosis , PDE
	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.		Apoptosis , PDE