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Rocepafant

Name: Rocepafant
Brand: TargetMol
SKU: T28607
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28607Cas No. 132579-32-9

Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730

Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.

Rocepafant

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Purity: 98.95%

Catalog No. T28607Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730Cas No. 132579-32-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$303	In Stock	In Stock
50 mg	$413	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
Targets&IC50	PAF receptor:0.74 nM
In vivo	Ten patients with active disease were treated for 4 weeks with a PAF receptor antagonist, Rocepafant, given orally (40 mg twice daily). The treatment period was followed by a 4-week follow-up period. Clinical indicators of disease activity significantly improved during the treatment period, with a progressive return to baseline values during the follow-up period. No significant change in laboratory variables was observed. The tolerance of the treatment was excellent, and no clinical or laboratory evidence of side effects was recorded. These results must be confirmed in a controlled study, but suggest an anti-inflammatory effect.[4]
Synonyms	LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730

Chemical Properties

Molecular Weight	535.08
Formula	C₂₆H₂₃ClN₆OS₂
Cas No.	132579-32-9
Smiles	CC=1N2C3=C(C4=C(S3)CN(C(NC5=CC=C(OC)C=C5)=S)CC4)C(=NCC2=NN1)C6=C(Cl)C=CC=C6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8689 mL	9.3444 mL	18.6888 mL	93.4440 mL
5 mM	0.3738 mL	1.8689 mL	3.7378 mL	18.6888 mL
10 mM	0.1869 mL	0.9344 mL	1.8689 mL	9.3444 mL
20 mM	0.0934 mL	0.4672 mL	0.9344 mL	4.6722 mL
50 mM	0.0374 mL	0.1869 mL	0.3738 mL	1.8689 mL
100 mM	0.0187 mL	0.0934 mL	0.1869 mL	0.9344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc