nad

Carba-NAD TEA is a NAD derivative that acts as a competitive inhibitor of calf splenic NAD+ hydrolase.

8-ET-NAD+ (sodium) is a derivative of NAD+ and is utilized for screening PARP1 gate mutations. It is also applicable in cancer research.

8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium)) is a derivative of NAD+, which functions as a signaling molecule and enzyme cofactor. This compound is utilized in screening gatekeeper mutations of PARP1 (poly[ADP-ribose] polymerase 1) that are sensitive to analogs.

8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for screening analog-sensitive gatekeeper mutations in poly (ADP-ribose) polymerase 1 (PARP1) and for synthesizing cyclic ADP-ribose (cADPR) derivatives.

Selective, high affinity 5-HT1A receptor antagonist

Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM.

NAD sodium (β-DPN sodium) is distributed across all human cells, involved in thousands of biochemical reactions, and is an essential coenzyme in the body.

Thio-NAD, a thione-modified derivative of the signaling molecule and enzyme cofactor NAD+, can substitute for NAD+ as a cofactor in alkaline phosphatase (ALP) enzyme activity assays. It is utilized as a substrate in dual-enzyme cycling ELISA for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, or surface glycoprotein, and live M. tuberculosis in patient sputum. Thio-NAD is characterized by its absorbance at 405 nm, distinguishing it from other cofactors.

6-Biotin-17-NAD+ sodium (Biotin-LC-NAD+ sodium) is a biotinylated derivative of NAD+ and can be used to measure NADH dehydrogenase activity.

8-(2-azidobenzylthio) NAD+ is a derivatized version of NAD+, a signaling molecule and enzyme cofactor, featuring an azido group (azidobenzylthio) that enables click chemistry applications.

8-(4-Azidophenacylthio) NAD+ is a clickable variant of the essential signaling molecule and enzyme cofactor, NAD+.

Carba-NAD sodium is a carbocyclic analog of NAD+ and is a good competitive inhibitor of calf spleen NAD+ glycohydrolase.

8-PT-NAD+ (sodium) is an analog of β-NAD+ and is utilized for screening NAD+ receptor proteins.

8-PIP-NAD+ (sodium) (8-Piperidino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for the detection of Poly(ADP-ribose) Polymerase (PARP) target proteins. Additionally, 8-PIP-NAD+ (sodium) serves as a synthetic intermediate for cyclic ADP-ribose (cADPR) derivatives.

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

NAD Synthetase is responsible for the final step in the synthesis of Nicotinamide Adenine Dinucleotide (NAD). The enzyme sourced from Escherichia coli exhibits Km values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia. Conversely, NAD Synthetase derived from yeast demonstrates Km values of 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia. This enzyme is applicable in enzymatic assays for ATP, ammonia, urea, or creatinine and can also be used in enzymatic recycling methods. Additionally, NAD Synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative disorders.

NAD+ lithium (β-DPN lithium) is the lithium salt form of nicotinamide adenine dinucleotide. This coenzyme plays a crucial role in redox reactions and can directly or indirectly influence various key cellular functions, such as metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell functions.

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.

NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

Nicotinic Acid Adenine Dinucleotide is a precursor of NAD (Nicotinamide adenine dinucleotide) and a substrate for glutamine-dependent NAD+ synthase, widely used in biochemical experiments and drug synthesis research.

NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.