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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP2192 | Cdk2/Cyclin Inhibitory Peptide I | Others | |
Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar... | |||
T76377 | Cdk2/Cyclin Inhibitory Peptide II | ||
Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1]. | |||
T82758 | CDK9-Cyclin T1 PPI-IN-1 | CDK | |
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt... | |||
T2029 | Bohemine | ERK , CDK | |
Bohemine is a cyclin-dependent kinase inhibitor. | |||
T7426 | ALSTERPAULLONE | Apoptosis , GSK-3 , CDK | |
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec | |||
T60025 | Eciruciclib | CDK | |
Eciruciclib is an inhibitor of CDK with antitumor properties. | |||
T39957 | CDK4/6-IN-6 | CDK | |
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. | |||
T5673 | Senexin A | CDK | |
Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively. | |||
T9849 | HQ461 | CDK , Molecular Glues | |
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. | |||
T7789 | DRB | HIV Protease | |
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM) | |||
T2356 | Ro-3306 | Apoptosis , ERK , SGK , PKA , CDK , PKC | |
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases. | |||
T5395 | BSJ-03-123 | CDK | |
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader. | |||
T5358 | Longdaysin | ERK , Casein Kinase , CDK | |
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM). | |||
T10436 | AZD4573 | CDK | |
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies. | |||
T4482 | CC-671 | Others , CDK | |
CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor. | |||
T8484 | JSH-150 | CDK | |
JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM). | |||
T14901 | CCT-251921 | CDK | |
CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM). | |||
T8801 | SRI-29329 | CDK | |
SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively). | |||
T16391 | ON-013100 | CDK | |
ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. | |||
T14916 | CDK2-IN-4 | CDK | |
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM. | |||
T6312 | R547 | Ro 4584820 | Apoptosis , GSK-3 , PKA , CDK |
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. | |||
T3352 | XL413 | cholecystokinin , Casein Kinase , Pim , CDK | |
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA ... | |||
TQ0266 | MSC2530818 | CDK | |
MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM). | |||
T4293 | THZ531 | CDK | |
THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). | |||
T8378 | AS2863619 | CDK , STAT | |
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively). | |||
T16021 | MBQ-167 | CDK , Ras | |
MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively). | |||
TQ0060 | LY2857785 | Apoptosis , CDK | |
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). | |||
T8325 | SR-4835 | Apoptosis , CDK | |
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells | |||
T6924 | Riviciclib hydrochloride | P276-00 | Apoptosis , CDK |
Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3. | |||
T2506 | AZD-5438 | AZD5438 | CDK |
AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM). | |||
T16359 | NU6140 | CDK , Aurora Kinase | |
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... | |||
T7810 | LY3177833 | LY-3177833 | CDK |
LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM) | |||
T6167 | SU9516 | Apoptosis , p38 MAPK , CDK , PKC , Autophagy | |
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively. | |||
T13202 | Trilaciclib hydrochloride | G1T28 hydrochloride | CDK |
Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6). | |||
T6205 | AT7519 | Apoptosis , GSK-3 , CDK | |
AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7. | |||
T9758 | DCeMM3 | 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide | Others |
dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati... | |||
T11929 | M2N12 | Phosphatase | |
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhi... | |||
TQ0053 | Fadraciclib | CYC065 | CDK |
Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM). | |||
T17069 | THAL-SNS-032 | CDK | |
THAL-SNS-032 is a selective CDK9 degrader PROTAC. | |||
T2028 | NG 52 | NG52,NG-52,Compound 52 | CDK |
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase. | |||
T16363 | NVP-2 | Apoptosis , CDK | |
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD... | |||
T11345L | Lerociclib dihydrochloride | G1T38 dihydrochloride | CDK |
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively. | |||
T13467 | (±)-Enitociclib | (±)-BAY-1251152 | CDK |
(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9. | |||
T2113 | PHA-793887 | PHA 793887,PHA793887 | Apoptosis , CDK |
PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors. | |||
T10736 | CDK4/6-IN-2 | CDK | |
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM). | |||
T6081 | Milciclib | PHA-848125 | Trk receptor , CDK , Autophagy |
Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2. | |||
T10744L | SEL120-34A HCl | CDK | |
SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity. | |||
T9117 | BSJ-4-116 | CDK , Ligand for E3 Ligase | |
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). | |||
T9615 | CK7 | CDK | |
CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367. | |||
T6126 | JNJ-7706621 | JNJ 7706621 | Apoptosis , CDK , Aurora Kinase |
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5S1467 | Cucurbitacin E | CDK , Autophagy | |
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot... | |||
T16324 | Nimbolide | Apoptosis , NF-κB , CDK | |
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ... | |||
T2933 | Wogonin | Vogonin | Apoptosis , Wnt/beta-catenin , CDK , Autophagy |
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. | |||
TN1637 | Eurycomalactone | Anti-infection , NF-κB | |
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in... | |||
TN1673 | Garcinone C | ATM/ATR , CDK , STAT , AChR , Antifection | |
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe... | |||
T7444 | 6-(Dimethylamino)purine | N,N-Dimethyladenine | Serine/threonin kinase , CDK |
6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor | |||
TN1299 | Desmethylglycitein | 6,7,4'-Trihydroxyisoflavone | PI3K , CDK , PKC |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. | |||
T17143 | Toyocamycin | Vengicide | Apoptosis , Others , IRE1 , Antibiotic , Antifungal |
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis. | |||
T7060 | Amantadine | 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine | Others |
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. | |||
T0912L | Tetracycline | Deschlorobiomycin,Tetracyclinum,Tetracyclin | Others , ribosome , Antibacterial , Antibiotic |
Tetracycline (Tetracyclin) is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. | |||
T1400 | Demeclocycline hydrochloride | Declomycin,Clortetrin,Detravis,Demeclocycline HCl | ribosome , Antibacterial , Antibiotic |
Demeclocycline hydrochloride (Declomycin) is a TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time. | |||
T1304 | Chlortetracycline hydrochloride | Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride | ribosome , Antibacterial , Antibiotic |
Chlortetracycline Hydrochloride is a tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride (Isphamycin) is bacteriostatic and inhibits bacterial protein synthesis by b... | |||
T6624 | Oxytetracycline Dihydrate | Terramycin Dihydrate | Others , Endogenous Metabolite , Antibacterial , Antibiotic , HSV |
Oxytetracycline Dihydrate (Terramycin Dihydrate) is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins. | |||
T1687L | Doxycycline (hyclate) | Doxycycline hydrochloride hemiethanolate hemihydrate,WC2031,Doxycycline hyclate | MMP , ribosome , Antibacterial , Antibiotic |
Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor act... | |||
T0912 | Tetracycline hydrochloride | NCI-c55561,Tetracycline HCl | ribosome , Antibacterial , Antibiotic |
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium ... | |||
T21430 | Oxytetracycline Hydrochloride | Biosolvomycin,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin | Antiviral , Endogenous Metabolite , Antibacterial , HSV |
Oxytetracycline Hydrochloride (Dalimycin) is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resultin... | |||
T1687 | Doxycycline | Vibramycin,Doxiciclina,Doxytetracycline,Doxycyclinum | MMP , ribosome , Antibacterial , Antibiotic , Parasite |
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity. | |||
T8259 | Doxycycline monohydrate | MMP , Antibacterial , Antibiotic , Parasite | |
Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP) | |||
T0518 | Methacycline hydrochloride | Rondomycin,Methacycline HCl | ribosome , Antibacterial , Antibiotic |
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | |||
T0895 | Oxytetracycline | Terramycin | ribosome , Endogenous Metabolite , Antibacterial , Antibiotic , HSV |
Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions. | |||
T0281 | Meclocycline sulfosalicylate salt | Meclutin,Mecloderm,Meclan Cream | Antibacterial , Antibiotic |
Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically. | |||
T79931 | Mutanocyclin | ||
Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mo... | |||
T12712 | Reutericyclin | Reutericycline | Others |
Reutericyclin is a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. | |||
T6169 | Indirubin | Indigopurpurin,Indigo red,NSC 105327,Couroupitine B | Apoptosis , Raf , GSK-3 , CDK |
Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM. | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... | |||
T6S0221 | Eriocitrin | eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside | Apoptosis , Carbonic Anhydrase |
1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet.... | |||
T3S0737 | Flavokawain A | Flavokavain A | Apoptosis , p38 MAPK |
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant... | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
TN1674 | Garcinone D | Reactive Oxygen Species , Nrf2 , STAT | |
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti... | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T27305 | Fascaplysin chloride | NSC622398,NSC 622398,Fascaplysin,NSC-622398 | |
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ... | |||
TN3673 | Clausine Z | CDK | |
Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro. | |||
TMA1012 | Ganoderiol F | Androgen Receptor , HIV Protease , Autophagy | |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced... | |||
TN6198 | Mahanine | ||
Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can r... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01401 | Cyclin A1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of... | |||
TMPY-01550 | Cyclin E Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that... | |||
TMPY-02777 | Cyclin E Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that... | |||
TMPY-03535 | Cyclin E Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that... | |||
TMPY-04548 | CDK4 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel... | |||
TMPY-04556 | CDK5 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which... | |||
TMPJ-00972 | CDKN1B Protein, Human, Recombinant (His) | Human | E. coli |
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele... | |||
TMPJ-00936 | CCND2 Protein, Human, Recombinant (His) | Human | E. coli |
CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ... | |||
TMPY-04549 | CDK1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote... | |||
TMPJ-00963 | CDKN2C Protein, Human, Recombinant (His) | Human | E. coli |
Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in... | |||
TMPY-04542 | CDK2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas... | |||
TMPH-00081 | CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | Yeast |
Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear numbe... | |||
TMPY-04775 | CDK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote... | |||
TMPY-04776 | PCTAIRE1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
TMPY-02921 | CDK2AP2 Protein, Human, Recombinant (His) | Human | E. coli |
CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including... | |||
TMPH-01170 | CDK5R1 Protein, Human, Recombinant (His) | Human | E. coli |
CDK5R1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-04463 | CDKL2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus... | |||
TMPY-02495 | P19 INK4d Protein, Human, Recombinant (GST) | Human | E. coli |
Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran... | |||
TMPY-04449 | CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
TMPH-01169 | CDK4 Protein, Human, Recombinant (His) | Human | E. coli |
CDK4 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01171 | CDK5 Protein, Human, Recombinant | Human | E. coli |
CDK5 Protein, Human, Recombinant is expressed in E. coli. | |||
TMPH-01359 | CCND1 Protein, Human, Recombinant (His) | Human | E. coli |
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylat... | |||
TMPH-01168 | CDKN2B Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CDKN2B Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-01167 | CDK1 Protein, Human, Recombinant (His) | Human | E. coli |
CDK1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01930 | CBFA2T1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CBFA2T1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-00675 | ZNHIT1 Protein, Human, Recombinant (His) | Human | E. coli |
ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at lea... | |||
TMPH-01173 | CDK7 Protein, Human, Recombinant | Human | E. coli |
CDK7 Protein, Human, Recombinant is expressed in E. coli. | |||
TMPH-01172 | CDK7 Protein, Human, Recombinant (His) | Human | Baculovirus |
CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus. | |||
TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-03599 | RPRD1B Protein, Human, Recombinant (His) | Human | HEK293 |
RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phospho... | |||
TMPK-00016 | Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated | Human,Mouse,Goat | E. coli |
Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer... | |||
TMPK-00015 | Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) | Human,Mouse,Goat | E. coli |
Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer... | |||
TMPH-02471 | 14-3-3 beta/alpha Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti... | |||
TMPH-02472 | 14-3-3 beta/alpha Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti... | |||
TMPY-03411 | ENSA Protein, Human, Recombinant (His) | Human | E. coli |
Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ... | |||
TMPY-02076 | PIN1 Protein, Human, Recombinant (His) | Human | E. coli |
Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptid... | |||
TMPY-02114 | PIN1 Protein, Human, Recombinant | Human | E. coli |
Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptid... | |||
TMPY-05654 | ENSA Protein, Human, Recombinant (His), Biotinylated | Human | E. coli |
Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ... | |||
TMPH-01831 | Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc) | HPV 16 | E. coli |
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph... | |||
TMPJ-01097 | ZBTB17 Protein, Human, Recombinant (His) | Human | E. coli |
Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific g... | |||
TMPH-01826 | Human Papilloma Virus type 11 (HPV 11) Protein E4 (His) | HPV 11 | E. coli |
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph... | |||
TMPH-01839 | Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc) | HPV 6a | E. coli |
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph... | |||
TMPY-04023 | BCCIP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-00578 | BCCIP Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-02766 | PSPH Protein, Human, Recombinant | Human | E. coli |
Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a ro... | |||
TMPH-01329 | FBXW7 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho... | |||
TMPH-02574 | P53 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-03264 | P53 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPY-01435 | Progranulin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-00150 | IGF2/IGF-II Protein, Human, Recombinant | Human | Yeast |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,... | |||
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Cat No. | Product Name | ||
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L8100 | Cell Cycle Compound Library | 695 compounds | |
A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS); |