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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3404 Altholactone 65408-91-5 98%
Altholactone
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257 Tanshinone IIB 17397-93-2 98%
Tanshinone IIB
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4932 Sageone 142546-15-4 98%
Sageone
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
T79497 M826 98%
M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro...
T79498 M867 680999-39-7 98%
M867
M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].
T79747 M190S 2578300-07-7 98%
M190S
M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo. It shows promise...
T79992 Sarglaroids F 98%
Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+ efflu...
T80093 IETD-CHO TFA 98%
IETD-CHO TFA
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].
T80109 Z-VEID-AFC 219138-06-4 98%
Z-VEID-AFC
Z-VEID-AFC is a caspase-6 fluorescent substrate [1].
T80110 Ac-VRPR-AMC 919515-51-8 98%
Ac-VRPR-AMC
Ac-VRPR-AMC is a fluorogenic substrate for metacaspase activity assays, facilitating the detection and measurement of metacaspase activity [1].
T80201 Tripeptide-32 1185583-20-3 98%
Tripeptide-32
Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].
T80467 Boc-AEVD-CHO 220094-15-5 98%
Boc-AEVD-CHO
Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].
T80531 Ac-AAVALLPAVLLALLAP-DEVD-CHO 201608-15-3 98%
Ac-AAVALLPAVLLALLAP-DEVD-CHO
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].
T80532 Ac-AAVALLPAVLLALLAP-YVAD-CHO 201608-12-0 98%
Ac-AAVALLPAVLLALLAP-YVAD-CHO
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].
T80536 Ac-AAVALLPAVLLALLAP-LEVD-CHO 886462-82-4 98%
Ac-AAVALLPAVLLALLAP-LEVD-CHO
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4 that exhibits antitumor activity [1].
T80537 Ac-AAVALLPAVLLALLAP-LEHD-CHO 623948-42-5 98%
Ac-AAVALLPAVLLALLAP-LEHD-CHO
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated with Neocarzinostatin...
T80545 Ac-VEID-AFC 98%
Ac-VEID-AFC
Ac-VEID-AFC is a fluorogenic substrate for caspase-6, utilized in caspase-6 activity assays [1].
T80624 Ac-VAD-CHO 147837-52-3 98%
Ac-VAD-CHO
Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of cytochrome...
T80659 Z-YVAD-CMK 402474-85-5 98%
Z-YVAD-CMK
Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].
T80745 Z-Ala-Ala-Asp-CMK 183284-21-1 98%
Z-Ala-Ala-Asp-CMK
Z-Ala-Ala-Asp-chloromethylketone (Z-AAD-CMK) is a selective inhibitor of granzyme B [1].
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Sageone
TN4932
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
M826
T79497
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro...
M867
T79498
M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].
M190S
T79747
M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo. It shows promise...
Sarglaroids F
T79992
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+ efflu...
IETD-CHO TFA
T80093
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].
Z-VEID-AFC
T80109
Z-VEID-AFC is a caspase-6 fluorescent substrate [1].
Ac-VRPR-AMC
T80110
Ac-VRPR-AMC is a fluorogenic substrate for metacaspase activity assays, facilitating the detection and measurement of metacaspase activity [1].
Tripeptide-32
T80201
Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].
Boc-AEVD-CHO
T80467
Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].
Ac-AAVALLPAVLLALLAP-DEVD-CHO
T80531
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].
Ac-AAVALLPAVLLALLAP-YVAD-CHO
T80532
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].
Ac-AAVALLPAVLLALLAP-LEVD-CHO
T80536
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4 that exhibits antitumor activity [1].
Ac-AAVALLPAVLLALLAP-LEHD-CHO
T80537
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated with Neocarzinostatin...
Ac-VEID-AFC
T80545
Ac-VEID-AFC is a fluorogenic substrate for caspase-6, utilized in caspase-6 activity assays [1].
Ac-VAD-CHO
T80624
Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of cytochrome...
Z-YVAD-CMK
T80659
Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].
Z-Ala-Ala-Asp-CMK
T80745
Z-Ala-Ala-Asp-chloromethylketone (Z-AAD-CMK) is a selective inhibitor of granzyme B [1].
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TargetMol