Glyoxalase

S-Methylglutathione (S-Methyl glutathione) is an S-substituted glutathione, an inhibitor of the 1-chloro-2,4-dinitrobenzene coupling catalyzed by transferase A and an XOCl scavenger.S-Methylglutathione inhibits glyoxalase 1 (glyoxalase 1), which induces the development of the glyoxalase 1 enzyme. S-Methylglutathione inhibits glyoxalase 1 (glyoxalase 1) and induces the formation of hydroid tentacle balls.

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

Glyoxalase I inhibitor (free base), a candidate for anticancer agents, is a potent Glyoxalase I (GLO1) inhibitor.

N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a Ki of 0.32 mM [1].

Methyl gerfelin, a potent GLO1 inhibitor belonging to the flavonoid class [1] [2], suppresses osteoclast differentiation by targeting and binding three critical cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat-containing protein A (SGTA).

N,S-Bis-Fmoc-Glutathione TFA is a potent inhibitor of glyoxalase II, exhibiting a Ki value of 0.75 μM and an IC50 value of 2.5 μM.

Glyoxalase I inhibitor 4 is a potent inhibitor of glyoxalase I (GLO1) (Ki: 10 nM).

Glyoxalase I inhibitor 1 is a potent inhibitor of glyoxalase I (GLO1) (IC50: 26 nM).

Glyoxalase I inhibitor 2 (compound 26) is a potent inhibitor of glyoxalase I (GLO1) with an IC50 of 0.5 μM, and has potential applications in depression and anxiety studies.

4BAB (compound 29) is an irreversible inhibitor of glyoxalase I (GLO1) with notable anticancer activity.

Glyoxalase I inhibitor, a candidate for anticancer agents, is a potent Glyoxalase I (GLO1) inhibitor.

Glyoxalase I inhibitor 5 (Compound 9h) is a potent glyoxalase I (Glo-I) inhibitor with an IC50 of 1.28 μM, showing potential as an anticancer agent [1].

Glyoxalase I Inhibitor 3 (compound 22g), a potent inhibitor of glyoxalase I (GLO1), demonstrates an IC50 of 0.011 μM, indicating significant efficacy. This compound shows promise for research into depression and anxiety [1].

COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].

HBPC-GSH, a derivative of glutathione, functions as an inhibitor for the glyoxalase system, specifically inhibiting cGloI and cGloII with IC50 values of 0.6μM and 1.6μM, respectively. This compound is utilized in antimalarial research [1].

Glyoxalase I inhibitor 7 (Compound 6) is a potent glyoxalase I (Glo-I) inhibitor with an IC50 of 3.65 μM, exhibiting potential as an anticancer agent [1].

Glyoxalase I inhibitor 6 (Compound 9j) is an inhibitor of glyoxalase I (Glo-I) with an IC50 of 1.13 μM, exhibiting potential as a low-toxicity anticancer agent [1].