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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(103)

Glyoxalase

(18)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(108)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(294)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(2)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(105)

Stearoyl-CoA Desaturase (SCD)

MTP

MTP (Microsomal Triglyceride Transfer Protein) is an endoplasmic reticulum membrane protein primarily responsible for lipid transport and lipoprotein assembly. Expressed in liver, intestine, and adipocytes, MTP promotes lipoprotein maturation and secretion by transferring triglycerides and cholesterol esters to nascent lipoprotein particles. MTP regulates blood triglyceride and cholesterol levels, with its dysfunction implicated in various lipid metabolism disorders such as familial hypobeta-lipoproteinaemia and cardiovascular disease.

Filter HomeSignaling PathwaysMetabolismMTP

Dirlotapide

Slentrol, CP742033

T15006481658-94-0In house

Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation.

MTP

$750

In Stock

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Lomitapide

BMS-201038, AEGR-733

T6267182431-12-5

Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.

MTP Others

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Lomitapide Mesylate

BMS-201038 mesylate, AEGR-733 mesylate

T2545202914-84-9

Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.

MTP

In Stock

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QTY

Granotapide

T31992594842-13-4In house

Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, and hypertension.

MTP

$210

In Stock

Size

QTY

KD-026

SLx-4090, SLx4090, SLx 4090, KD026

T27719913541-47-6

KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.

MTP Others

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CP-346086

T39303186390-48-7

CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces plasma levels of cholesterol and triglycerides when administered in vivo.

MTP Others

Inquiry

Inquiry

PF-02575799

T16158863491-70-7

PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).

Adenosine Receptor MTP

$1,820

8-10 weeks

Size

QTY

CP-346086 dihydrate

T386661262769-98-1

CP-346086 dihydrate is a potent, orally active inhibitor of microsomal triglyceride transfer protein (MTP), with an IC50 of 2.0 nM for both human and rodent MTP, effectively lowering plasma cholesterol and triglyceride levels in vivo.

MTP Others