s4

CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

RhlR agonist S4 is a quorum sensing modulator as an RhlR agonist.

Apratoxin S4 (Apra S4), a potent inhibitor of Sec61, disrupts the cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER), showcasing antiviral efficacy against select flaviviruses with IC 50 values spanning 0.46 nM to 170 nM. It also curtails retinal vascular cell activation by targeting various angiogenic pathways. This compound is valuable for investigating viral infections, angiogenic diseases, and cancers [1] [2].

Dermaseptin-S4, an antimicrobial peptide sourced from frog skin, exhibits efficacy against filamentous fungi [1].

Maximin S4, an antimicrobial peptide sourced from the toad Bombina maxima, exhibits antibacterial activity against mycoplasma [1].

BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.

PS423 (PS210AM) is a substrate-selective inhibitor of PDK1 and a selective PDK1 activator that inhibits the phosphorylation and activation of S6K, and is used in the study of endocrine and metabolic disorders.

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.

GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.

OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .

YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a binding affinity with a K_i value of 37 nM.

RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.

MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.

PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.

CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.

MS402 is a novel BD1-selective BET BrD inhibitor.

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

CS476 is a potent drug of hypoglycaemic.

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.

MRS4865 (compound 7a) serves as a chimeric antagonist for the P2Y14 receptor and an agonist for UDP-glucose, offering protection against neuropathic pain.