choline

Choline hydroxide is a ubiquitous water soluble nutrient, often associated with the B vitamins

Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.

Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.

Hemicholinium 3 is a potent and selective choline uptake blocker.

Choline is the parent compound of choline compounds, with a structure in which the amino group of ethanolamine is substituted by three methyl groups. Choline acts as a neurotransmitter, nutrient, and allergen, and is an endogenous metabolite in mice, Saccharomyces cerevisiae, plants, Escherichia coli, humans, and Daphnia magna. Choline is involved in the regulation of gallbladder function, hepatic physiology, and the synthesis of the key lipid lecithin; it promotes fat and cholesterol metabolism, reduces excessive fat accumulation in the liver, and can also be used to alleviate symptoms associated with Parkinsonism and tardive dyskinesia. Choline deficiency may cause abnormal hepatic fat deposition, hypertension, gastric ulcers, liver and kidney damage, growth retardation, and other disorders.

Linzagolix choline is an orally available non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC₅₀: 34 nM).

Choline is a vital nutrient essential for maintaining liver, neurological, hematological, and skeletal muscle balance. It serves as a precursor in the biosynthesis of membrane phospholipids, like phosphatidylcholine, which aid in cell signaling and membrane transport, and is also a precursor to the neurotransmitter acetylcholine. Choline is crucial for hepatic lipid transport. In animal studies, perinatal administration of choline (18.8 mg/kg) has been shown to enhance cognitive function impaired by prenatal alcohol exposure in rats. Additionally, choline (13 mg/animal per day) improves motor coordination and addresses behavioral issues in a mouse model of Rett syndrome, and mitigates recognition memory deficits caused by early-life iron deficiency in rats when provided in drinking water at 5 ppm. Low choline intake is linked to muscle wasting, and dietary choline (1,000 mg/kg) boosts leg and breast muscle protein content in broiler chickens.

Salicylate choline is a derivative of Aspirin (acetylsalicylic acid) and is orally active. It significantly reduces the levels of IL-1β, IL-6, TNF-α, and IL-10 in cells. By inducing S phase cell cycle arrest and impairing DNA damage repair, salicylate choline enhances the antitumor activity of the CRM1 inhibitor Selinexor (KPT-330). When combined with Selinexor, salicylate choline demonstrates excellent antitumor efficacy in mouse xenograft models with JeKo-1 cells. It is applicable in the research of rheumatism, inflammation, and cancer.

Choline acetate is a choline-based ionic liquid that enhances lipase activity. It serves as a plasticizer or an ionic liquid component to improve carrier structure and release properties, thereby enhancing the performance of biomaterials.

TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(

Alpha-Lipoic Acid Choline Ester is used potentially to treat presbyopia.

R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.

Glycerophosphoinositol choline is the salt of choline and glycerophosphoinositol.

Methyl-D9-choline is an isotopically labeled choline tracer.

Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from w

Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and potent agonist of the TPO receptor and therefore induces differentiation and proliferation of megakaryocytes. The pharmacologic characteristics indicate potential therapeutic use in thrombocytopenic patients with a variety of clinical etiologies.

YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK/Ay type 2 diabetic mice, effects that were sustained even after 12 h.

Choline oxidase is an enzyme that facilitates the conversion of choline to glycine betaine through an intermediate, betaine aldehyde, during the synthesis of glycine betaine. Glycine betaine serves as an osmolyte. Furthermore, choline oxidase shows promise for use in the enzymatic production of betaine [1].

Choline hexanoate, an ionic liquid, serves as a protective agent to prevent acid-induced steel degradation, and it also functions as a lytic agent for isolating bacterial DNA.

Fos-Choline-10 is a useful organic compound for research related to life sciences. The catalog number is TF0022 and the CAS number is 70504-28-8.

Fos-Choline-14 is a useful organic compound for research related to life sciences. The catalog number is TF0023 and the CAS number is 77733-28-9.

Fos-Choline-ISO-11 is a useful organic compound for research related to life sciences. The catalog number is TF0024 and the CAS number is 869647-65-4.