choline

Choline is a ubiquitous water soluble nutrient, often associated with the B vitamins

Linzagolix choline is an orally available non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(

Glycerophosphoinositol choline is the salt of choline and glycerophosphoinositol.

Methyl -D9- choline is an isotopically labeled choline tracer.

Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from w

Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and potent agonist of the TPO receptor and therefore induces differentiation and proliferation of megakaryocytes. The pharmacologic characteristics indicate potential therapeutic use in thrombocytopenic patients with a variety of clinical etiologies.

YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK/Ay type 2 diabetic mice, effects that were sustained even after 12 h.

Choline bis(trifluoromethylsulfonyl)imide, an ionic liquid, is utilized for extracting phenolic compounds from water and serves as a thermally responsive ionic liquid in closed-loop osmotic heat engines.

Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

Succinylcholine Chloride Dihydrate (Succinyldicholine dichloride) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.

Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.

Choline theophyllinate (Oxtriphylline) is the choline salt of theophylline, a small molecule PDE inhibitor that can be used to treat immune system disorders and respiratory disorders, and to study asthma disorders.

Choline-d9 chloride is a deuterium-labelled derivative of choline chloride for isotope tracing. Choline chloride, an essential nutrient, activates α7 nicotinic acetylcholine receptors and exhibits anti-inflammatory and analgesic properties.

R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.

p-Nitrophenylphosphorylcholine is a chromogenic substrate for measuring phospholipase C activity, releasing p-nitrophenol that can be quantified at 405 nm.

Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.

Choline-d4 Chloride (Choline-1,1,2,2-D4 Chloride) is a deuterated form of Choline chloride, an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.

Choline-13C2 Chloride (Standard) is a reference standard of Choline-13C2 Chloride intended for quantitative analysis, quality control, and related biochemical research applications. Choline-13C2(chloride) is the 13C-labeled version of Choline chloride. As an essential nutrient, Choline chloride activates α7 nicotinic receptors (alpha7 nicotinic receptors) and exhibits analgesic and anti-inflammatory properties. It may influence conditions such as liver diseases, atherosclerosis, and neurological disorders.

Choline-D4 Chloride (Standard) is a reference standard of Choline-D4 Chloride intended for quantitative analysis, quality control, and related biochemical research applications. Choline-d4 Chloride (Choline-1,1,2,2-D4 Chloride) is a deuterated form of Choline chloride, an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.

Choline-D9 Chloride (Standard) is a reference standard of Choline-D9 Chloride intended for quantitative analysis, quality control, and related biochemical research applications. Choline-d9 chloride is a deuterium-labelled derivative of choline chloride for isotope tracing. Choline chloride, an essential nutrient, activates α7 nicotinic acetylcholine receptors and exhibits anti-inflammatory and analgesic properties.

Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. By suppressing the formation of diacylglycerol (DAG), it inhibits tumor growth in mice.