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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5168 | EGFR-IN-12 | EGFR Inhibitor | Apoptosis , EGFR |
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells. | |||
T21954 | EGFR/ErbB-2/ErbB-4 inhibitor-2 | EGFR/ErbB2 Inhibitor | EGFR |
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively) | |||
T2705 | Mutant EGFR inhibitor | EGFR | |
Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant. | |||
T10802 | CHMFL-EGFR-202 | EGFR | |
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases). | |||
T11163 | EGFR-IN-9 | EGFR | |
EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity. | |||
T11158 | EGFR-IN-11 | EGFR | |
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. | |||
T11160 | EGFR-IN-5 | EGFR | |
EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively. | |||
T11162 | EGFR-IN-8 | EGFR , c-Met/HGFR | |
EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC. | |||
T11157L | EGFR-IN-1 hydrochloride | EGFR | |
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride exhibits potent antitumor and antiproliferative activity... | |||
T11161 | EGFR-IN-7 | TQB3804 | EGFR |
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. | |||
T16162 | Mutated EGFR-IN-1 | Osimertinib analog | EGFR |
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant. | |||
T35901 | EGFR-IN-99 | JBJ-03-142-02 | EGFR , HER |
EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC). | |||
T63732 | EGFR-IN-3 | Apoptosis , EGFR | |
EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase. | |||
T75120 | EGFR-IN-76 | EGFR | |
EGFR-IN-76 is a potent EGFR inhibitor. | |||
TP1613 | [pTyr5] EGFR (988-993) | [pTyr5] EGFR 988-993 | |
[pTyr5] EGFR (988-993) is a compound obtained from the auto-phosphorylation site, Tyr992, located within the sequence of the epidermal growth factor receptor (EGFR 988-993). This compound is frequently found bound with t... | |||
T9905 | Cetuximab | Cetuximab (anti-EGFR),C225 | EGFR |
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis. | |||
T79861 | EGFR/ErbB-2 inhibitor-1 | EGFR | |
EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling. | |||
TQ0255 | Olafertinib | CK-101,EGFR-IN-3,RX-518 | EGFR |
Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC. | |||
T40209 | EGFR-IN-15 | ||
EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications. | |||
T11159 | EGFR-IN-2 | EGFR | |
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor. |