T8702 |
SKF-83566
|
99295-33-7
|
95.00%
|
|
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
|
T1769 |
Pardoprunox
|
269718-84-5
|
|
|
Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
|
T15100 |
Desmethyl cariprazine
|
839712-15-1
|
98%
|
|
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
|
T13240 |
U91356
|
152886-85-6
|
98%
|
|
U91356 is an agonist of the dopamine receptors.
|
T78514 |
Timiperone
|
57648-21-2
|
98%
|
|
Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior. It is utilized...
|
T78644 |
A-77636
|
778546-51-3
|
98%
|
|
A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 valu...
|
T78735 |
D1R antagonist 1
|
|
98%
|
|
Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].
|
T78736 |
D3R ligand 1
|
|
98%
|
|
D3R Ligand 1 (compound 23b) is a potent, selective antagonist of the dopamine D3 receptor (Ki=66 nM), incorporating a THPB template. It inhibits both G-protein- ...
|
T78778 |
D3R/MOR antagonist 1
|
|
98%
|
|
Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM ...
|
T78779 |
D3R/MOR antagonist 2
|
|
98%
|
|
Compound 121, a D3R/MOR antagonist with K i values of 361 nM and 85.2 nM for D3R and MOR respectively, has the potential for analgesic effects through MOR partia...
|
T79312 |
FGH31
|
|
98%
|
|
FGH31 (Compound 24), a dopamine D4 agonist, exhibits potent and selective GRK2-dependency with a K i of 1.6 nM and partially activates β-arrestin [1].
|
T81152 |
SKF 81297
|
71636-61-8
|
98%
|
|
SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].
|
T81336 |
PZ-1190
|
1852517-78-2
|
98%
|
|
PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].
|
T13387 |
Zatebradine
|
85175-67-3
|
98%
|
|
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
|
T10612 |
Brexpiprazole S-oxide
|
1191900-51-2
|
98%
|
|
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
|
T12252 |
NRA-0160
|
204718-47-8
|
98%
|
|
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
|
T12861L |
SB-277011 dihydrochloride
|
1226917-67-4
|
98%
|
|
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D...
|
T16511 |
PF2562
|
1609258-91-4
|
98%
|
|
PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity aga...
|
T14088 |
ABT-670
|
630119-43-6
|
98%
|
|
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
|
T12676 |
(Rac)-Rotigotine hydrochloride
|
102120-99-0
|
98%
|
|
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
|