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Dopamine Receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1769 Pardoprunox 269718-84-5
Pardoprunox
Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
T15100 Desmethyl cariprazine 839712-15-1 98%
Desmethyl cariprazine
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T13240 U91356 152886-85-6 98%
U91356
U91356 is an agonist of the dopamine receptors.
T78514 Timiperone 57648-21-2 98%
Timiperone
Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior. It is utilized...
T78644 A-77636 778546-51-3 98%
A-77636
A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 valu...
T78735 D1R antagonist 1 2983777-67-7 98%
D1R antagonist 1
Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].
T78736 D3R ligand 1 98%
D3R ligand 1
D3R Ligand 1 (compound 23b) is a potent, selective antagonist of the dopamine D3 receptor (Ki=66 nM), incorporating a THPB template. It inhibits both G-protein- ...
T78778 D3R/MOR antagonist 1 98%
D3R/MOR antagonist 1
Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM ...
T78779 D3R/MOR antagonist 2 98%
D3R/MOR antagonist 2
Compound 121, a D3R/MOR antagonist with K i values of 361 nM and 85.2 nM for D3R and MOR respectively, has the potential for analgesic effects through MOR partia...
T79312 FGH31 98%
FGH31
FGH31 (Compound 24), a dopamine D4 agonist, exhibits potent and selective GRK2-dependency with a K i of 1.6 nM and partially activates β-arrestin [1].
T81152 SKF 81297 71636-61-8 98%
SKF 81297
SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].
T81336 PZ-1190 1852517-78-2 98%
PZ-1190
PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].
T13387 Zatebradine 85175-67-3 98%
Zatebradine
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
T10612 Brexpiprazole S-oxide 1191900-51-2 98%
Brexpiprazole S-oxide
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
T12252 NRA-0160 204718-47-8 98%
NRA-0160
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
T12861L SB-277011 dihydrochloride 1226917-67-4 98%
SB-277011 dihydrochloride
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D...
T16511 PF2562 1609258-91-4 98%
PF2562
PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity aga...
T14088 ABT-670 630119-43-6 98%
ABT-670
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
T12676 (Rac)-Rotigotine hydrochloride 102120-99-0 98%
(Rac)-Rotigotine hydrochloride
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
T15339 Foscarbidopa 1907685-81-7 98%
Foscarbidopa
Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
Pardoprunox
T1769
Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
Desmethyl cariprazine
T15100
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
U91356
T13240
U91356 is an agonist of the dopamine receptors.
Timiperone
T78514
Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior. It is utilized...
A-77636
T78644
A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 valu...
D1R antagonist 1
T78735
Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].
D3R ligand 1
T78736
D3R Ligand 1 (compound 23b) is a potent, selective antagonist of the dopamine D3 receptor (Ki=66 nM), incorporating a THPB template. It inhibits both G-protein- ...
D3R/MOR antagonist 1
T78778
Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM ...
D3R/MOR antagonist 2
T78779
Compound 121, a D3R/MOR antagonist with K i values of 361 nM and 85.2 nM for D3R and MOR respectively, has the potential for analgesic effects through MOR partia...
FGH31
T79312
FGH31 (Compound 24), a dopamine D4 agonist, exhibits potent and selective GRK2-dependency with a K i of 1.6 nM and partially activates β-arrestin [1].
SKF 81297
T81152
SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].
PZ-1190
T81336
PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].
Zatebradine
T13387
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
Brexpiprazole S-oxide
T10612
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
NRA-0160
T12252
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
SB-277011 dihydrochloride
T12861L
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D...
PF2562
T16511
PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity aga...
ABT-670
T14088
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
(Rac)-Rotigotine hydrochloride
T12676
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
Foscarbidopa
T15339
Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
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TargetMol