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Cat No. | Product Name | Synonyms | Targets |
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TP1978L | NFAT inhibitor, Cell Permeable aceate | Others | |
NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy. | |||
T81824 | Membrane-Permeable Sequence, MPS | ||
Membrane-Permeable Sequence (MPS) is a cell-penetrating peptide (CPP) utilized in the investigation of membrane crossing mechanisms [1]. | |||
TP1978 | 11R-VIVIT | NFAT inhibitor, Cell Permeable | |
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ... | |||
T9230 | KM 91104 | ATPase | |
KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2. | |||
T7149 | S29434 | NADPH , Autophagy | |
S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM). | |||
T10363 | Arazine | N-Acetyl-S-farnesyl-L-cysteine | Others |
Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and G... | |||
T1908 | MHY1485 | mTOR , Autophagy | |
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes. | |||
T1923 | BRD4770 | Histone Methyltransferase | |
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. | |||
T9149 | 2BAct | 2B-Act,2B Act | PERK |
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response | |||
T5399 | GeA-69 | PARP | |
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). | |||
T12165 | NAChR agonist 1 | DUN71755 | AChR |
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. | |||
T12079 | ML604440 | Proteasome | |
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor. | |||
T40996 | Coppersensor 1 | Coppersensor 1,CS1 | Others |
Coppersensor 1 (CS1) is a boron dipyrromethene-based fluorescent sensor for selective and sensitive detection of copper(I) ions (Cu + ) in biological samples. Coppersensor 1 can be imaged using any type of fluorescence m... | |||
TP1015 | NFAT Inhibitor | VIVIT peptide | Others |
NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. | |||
T16409 | OSMI-1 | Others , Acyltransferase | |
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. | |||
TP1253 | Argireline | Acetyl hexapeptide-3 | Others |
Argireline (Acetyl hexapeptide-3) (Acetyl hexapeptide-3) is composed of chains of amino acids known as peptides. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscu... | |||
T3058 | (Z)-SMI-4a | TCS PIM-1 4a,SMI-4a | Pim |
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. | |||
T20684 | 2',7'-Dichlorofluorescein diacetate | Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,DCFDA | Others |
2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein), a cell-permeable fluorogenic probe, is useful for the detection of nitric oxide (NO) and reactive oxygen species (ROS) and for the determination of the d... | |||
T14389 | AZD 9272 | GluR | |
AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux. | |||
TQ0026 | MDR-1339 | DWK-1339 | Beta Amyloid , Gamma-secretase |
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. | |||
T28698 | SC-22716 | ||
SC-22716 is a cell-permeable leukotriene A4 (LTA4) hydrolase inhibitor which suppresses the production of LTB4. SC-22716 is implicated in the pathogenesis of many diseases including inflammatory bowel disease and psorias... | |||
T12327 | OSMI-3 | Others | |
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease. | |||
T11748 | KDM2A/7A-IN-1 | Others | |
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A. | |||
T12261 | NSC232003 | E1/E2/E3 Enzyme | |
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1. | |||
T2417 | Sal003 | Apoptosis , Phosphatase , PERK | |
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase. | |||
T64345 | 4-(Dimethylamino)phenol | Others | |
4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP co... | |||
T12942L | SN50 acetate (213546-53-3 free base) | NF-κB | |
SN50 acetate is a cell permeable inhibitor of NF-κB translocation. | |||
T23588 | 9-CP-Ade Mesylate | 9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate | AChR |
9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase. | |||
T6432 | Calpeptin | Apoptosis , Cysteine Protease , Proteasome | |
Calpeptin is a potent, cell-permeable calpain inhibitor. | |||
T22972 | Methoxy-X04 | Others | |
Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ). | |||
T21634 | N-Oxalylglycine | Oxalylglycine | Others |
N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes. | |||
T4216 | STAT5-IN-1 | STAT5 Inhibitor | STAT |
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. | |||
T7389 | G15 | Estrogen Receptor/ERR | |
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM) | |||
T10247 | Adenosine 5'-diphosphoribose sodium | Adenosine 5'-diphosphoribose sodium,ADP ribose sodium | Endogenous Metabolite , TRP/TRPV Channel , Autophagy |
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent ... | |||
T9956 | VK-28 | Mitochondrial Metabolism , Lipid | |
VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation. | |||
T12187L | Naspm trihydrochloride | 1-Naphthylacetyl spermine trihydrochloride | iGluR |
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors. | |||
T39989L | JQKD82 trihydrochloride | Histone Demethylase | |
JQKD82 trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma. | |||
T6629 | PYR-41 | PYR41,PYR 41 | Apoptosis , E1/E2/E3 Enzyme |
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. | |||
TQ0003 | 740 Y-P | 740YPDGFR,PDGFR 740Y-P | PI3K , Autophagy |
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. | |||
T1741 | AZD1080 | GSK-3 | |
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. | |||
T4026 | SU5408 | VEGFR2 Kinase Inhibitor I | VEGFR |
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase. | |||
T2451 | GlyH-101 | GlyH 101 | CFTR , Autophagy |
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. | |||
T4048 | Monastrol | (±)-Monastrol | Apoptosis , Kinesin |
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. | |||
T2502 | INH1 | IBT13131 | Apoptosis , Microtubule Associated |
INH1 (IBT13131) is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction. | |||
T1563 | Nifuroxazide | Diarlidan,Nifuroxazid,Dicoferin | Antibacterial , Antibiotic , STAT |
Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription. | |||
T10937L | D-JNKI-1 acetate | D-JNKI-1 acetate(1445179-97-4 Free base),AM-111 acetate | JNK |
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK. | |||
T17148 | TPPB | PKC | |
TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). | |||
T2432 | PD 169316 | Virus Protease , p38 MAPK , Autophagy | |
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor. | |||
T19323 | Fluorescein diacetate | 3,6-Diacetoxyfluoran,Di-O-acetylfluorescein | Others |
Fluorescein diacetate (Di-O-acetylfluorescein) is a cell permeable esterase-substrate for hGSTP1-1. | |||
T2661 | TGX-221 | TGX221 | PI3K |
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4183 | Lavendustin A | RG-14355,NSC 678027 | EGFR , Tyrosinase |
lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. | |||
T2933 | Wogonin | Vogonin | Apoptosis , Wnt/beta-catenin , CDK , Autophagy |
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. | |||
T3419 | Chelerythrine chloride | Apoptosis , BCL , PKC , Autophagy | |
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. | |||
T16012 | Marizomib | NPI-0052,Salinosporamide A,ML858 | Proteasome |
Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv... | |||
T8114 | Quercetagetin | 6-Hydroxyquercetin | Pim |
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM). | |||
T6564 | Leupeptin Hemisulfate | Serine Protease , Cysteine Protease | |
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc... | |||
T13493 | 3-Acetyldeoxynivalenol | Others | |
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin. | |||
T13630 | Cytochalasin C | Others | |
Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice. | |||
T29888 | Aloe-emodin-glucoside | ||
Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds. | |||
TN4343 | Jaceidin | 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone,Quercetagetin 3,3',6-trimethyl ether,Jaceidine | VEGFR , Antioxidant |
Jaceidin (Quercetagetin 3,3',6-trimethyl ether) is a membrane-permeable inhibitor of VEGFR with anti-tumor activities. | |||
T15638 | K-252c | PKC | |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ... | |||
T10928 | Cytochalasin A | HIV Protease | |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu... | |||
T14831 | Bryostatin 1 | HIV Protease , PKC | |
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.0... | |||
T73876 | Sanggenon G | ||
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances... | |||
T36439 | Gramicidin A | Antibacterial , HIF , Parasite | |
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01584 | KRT7 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. | |||
TMPH-03057 | Chorismate synthase Protein, Neurospora crassa, Recombinant (His) | Neurospora crassa | E. coli |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys... | |||
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel... | |||
TMPH-03426 | Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His) | RVX | Yeast |
This Recombinant Rotavirus X Outer capsid protein VP4 protein was made through genetic engineering. By putting the Outer capsid protein VP4 gene into the genetic material of Yeast cell, the Yeast could be used as factori... | |||
TMPH-01540 | Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t... |