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Search Results for " permeable "

Targets

481

Compounds

15

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
TP1978L NFAT inhibitor, Cell Permeable aceate Others
NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy.
T81824 Membrane-Permeable Sequence, MPS
Membrane-Permeable Sequence (MPS) is a cell-penetrating peptide (CPP) utilized in the investigation of membrane crossing mechanisms [1].
TP1978 11R-VIVIT NFAT inhibitor, Cell Permeable
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ...
T9230 KM 91104 ATPase
KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2.
T7149 S29434 NADPH , Autophagy
S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
T10363 Arazine N-Acetyl-S-farnesyl-L-cysteine Others
Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and G...
T1908 MHY1485 mTOR , Autophagy
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes.
T1923 BRD4770 Histone Methyltransferase
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
T9149 2BAct 2B-Act,2B Act PERK
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
T5399 GeA-69 PARP
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
T12165 NAChR agonist 1 DUN71755 AChR
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
T12079 ML604440 Proteasome
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
T40996 Coppersensor 1 Coppersensor 1,CS1 Others
Coppersensor 1 (CS1) is a boron dipyrromethene-based fluorescent sensor for selective and sensitive detection of copper(I) ions (Cu + ) in biological samples. Coppersensor 1 can be imaged using any type of fluorescence m...
TP1015 NFAT Inhibitor VIVIT peptide Others
NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.
T16409 OSMI-1 Others , Acyltransferase
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.
TP1253 Argireline Acetyl hexapeptide-3 Others
Argireline (Acetyl hexapeptide-3) (Acetyl hexapeptide-3) is composed of chains of amino acids known as peptides. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscu...
T3058 (Z)-SMI-4a TCS PIM-1 4a,SMI-4a Pim
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
T20684 2',7'-Dichlorofluorescein diacetate Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,DCFDA Others
2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein), a cell-permeable fluorogenic probe, is useful for the detection of nitric oxide (NO) and reactive oxygen species (ROS) and for the determination of the d...
T14389 AZD 9272 GluR
AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.
TQ0026 MDR-1339 DWK-1339 Beta Amyloid , Gamma-secretase
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T28698 SC-22716
SC-22716 is a cell-permeable leukotriene A4 (LTA4) hydrolase inhibitor which suppresses the production of LTB4. SC-22716 is implicated in the pathogenesis of many diseases including inflammatory bowel disease and psorias...
T12327 OSMI-3 Others
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.
T11748 KDM2A/7A-IN-1 Others
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A.
T12261 NSC232003 E1/E2/E3 Enzyme
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
T2417 Sal003 Apoptosis , Phosphatase , PERK
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T64345 4-(Dimethylamino)phenol Others
4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP co...
T12942L SN50 acetate (213546-53-3 free base) NF-κB
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
T23588 9-CP-Ade Mesylate 9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate AChR
9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase.
T6432 Calpeptin Apoptosis , Cysteine Protease , Proteasome
Calpeptin is a potent, cell-permeable calpain inhibitor.
T22972 Methoxy-X04 Others
Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).
T21634 N-Oxalylglycine Oxalylglycine Others
N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.
T4216 STAT5-IN-1 STAT5 Inhibitor STAT
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
T7389 G15 Estrogen Receptor/ERR
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
T10247 Adenosine 5'-diphosphoribose sodium Adenosine 5'-diphosphoribose sodium,ADP ribose sodium Endogenous Metabolite , TRP/TRPV Channel , Autophagy
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent ...
T9956 VK-28 Mitochondrial Metabolism , Lipid
VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
T12187L Naspm trihydrochloride 1-Naphthylacetyl spermine trihydrochloride iGluR
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
T39989L JQKD82 trihydrochloride Histone Demethylase
JQKD82 trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma.
T6629 PYR-41 PYR41,PYR 41 Apoptosis , E1/E2/E3 Enzyme
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
TQ0003 740 Y-P 740YPDGFR,PDGFR 740Y-P PI3K , Autophagy
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
T1741 AZD1080 GSK-3
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.
T4026 SU5408 VEGFR2 Kinase Inhibitor I VEGFR
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.
T2451 GlyH-101 GlyH 101 CFTR , Autophagy
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T4048 Monastrol (±)-Monastrol Apoptosis , Kinesin
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T2502 INH1 IBT13131 Apoptosis , Microtubule Associated
INH1 (IBT13131) is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T1563 Nifuroxazide Diarlidan,Nifuroxazid,Dicoferin Antibacterial , Antibiotic , STAT
Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.
T10937L D-JNKI-1 acetate D-JNKI-1 acetate(1445179-97-4 Free base),AM-111 acetate JNK
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.
T17148 TPPB PKC
TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
T2432 PD 169316 Virus Protease , p38 MAPK , Autophagy
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
T19323 Fluorescein diacetate 3,6-Diacetoxyfluoran,Di-O-acetylfluorescein Others
Fluorescein diacetate (Di-O-acetylfluorescein) is a cell permeable esterase-substrate for hGSTP1-1.
T2661 TGX-221 TGX221 PI3K
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.

Compounds

NFAT inhibitor, Cell Permeable aceate
TP1978L
Synonym:
Target: Others
Membrane-Permeable Sequence, MPS
T81824
Synonym:
Target:
11R-VIVIT
TP1978
Synonym: NFAT inhibitor, Cell Permeable
Target:
KM 91104
T9230
Synonym:
Target: ATPase
S29434
T7149
Synonym:
Target: NADPH, Autophagy
Arazine
T10363
Synonym: N-Acetyl-S-farnesyl-L-cysteine
Target: Others
MHY1485
T1908
Synonym:
Target: mTOR, Autophagy
BRD4770
T1923
Synonym:
Target: Histone Methyltransferase
2BAct
T9149
Synonym: 2B-Act,2B Act
Target: PERK
GeA-69
T5399
Synonym:
Target: PARP
nAChR agonist 1
T12165
Synonym: DUN71755
Target: AChR
ML604440
T12079
Synonym:
Target: Proteasome
Coppersensor 1
T40996
Synonym: Coppersensor 1,CS1
Target: Others
NFAT Inhibitor
TP1015
Synonym: VIVIT peptide
Target: Others
OSMI-1
T16409
Synonym:
Target: Others, Acyltransferase
Argireline
TP1253
Synonym: Acetyl hexapeptide-3
Target: Others
(Z)-SMI-4a
T3058
Synonym: TCS PIM-1 4a,SMI-4a
Target: Pim
2',7'-Dichlorofluorescein diacetate
T20684
Synonym: Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,DCFDA
Target: Others
AZD 9272
T14389
Synonym:
Target: GluR
MDR-1339
TQ0026
Synonym: DWK-1339
Target: Beta Amyloid, Gamma-secretase
SC-22716
T28698
Synonym:
Target:
OSMI-3
T12327
Synonym:
Target: Others
KDM2A/7A-IN-1
T11748
Synonym:
Target: Others
NSC232003
T12261
Synonym:
Target: E1/E2/E3 Enzyme
Sal003
T2417
Synonym:
Target: Apoptosis, Phosphatase, PERK
4-(Dimethylamino)phenol
T64345
Synonym:
Target: Others
SN50 acetate (213546-53-3 free base)
T12942L
Synonym:
Target: NF-κB
9-CP-Ade Mesylate
T23588
Synonym: 9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate
Target: AChR
Calpeptin
T6432
Synonym:
Target: Apoptosis, Cysteine Protease, Proteasome
Methoxy-X04
T22972
Synonym:
Target: Others
N-Oxalylglycine
T21634
Synonym: Oxalylglycine
Target: Others
STAT5-IN-1
T4216
Synonym: STAT5 Inhibitor
Target: STAT
G15
T7389
Synonym:
Target: Estrogen Receptor/ERR
Adenosine 5'-diphosphoribose sodium
T10247
Synonym: Adenosine 5'-diphosphoribose sodium,ADP ribose sodium
Target: Endogenous Metabolite, TRP/TRPV Channel, Autophagy
VK-28
T9956
Synonym:
Target: Mitochondrial Metabolism, Lipid
Naspm trihydrochloride
T12187L
Synonym: 1-Naphthylacetyl spermine trihydrochloride
Target: iGluR
JQKD82 trihydrochloride
T39989L
Synonym:
Target: Histone Demethylase
PYR-41
T6629
Synonym: PYR41,PYR 41
Target: Apoptosis, E1/E2/E3 Enzyme
740 Y-P
TQ0003
Synonym: 740YPDGFR,PDGFR 740Y-P
Target: PI3K, Autophagy
AZD1080
T1741
Synonym:
Target: GSK-3
SU5408
T4026
Synonym: VEGFR2 Kinase Inhibitor I
Target: VEGFR
GlyH-101
T2451
Synonym: GlyH 101
Target: CFTR, Autophagy
Monastrol
T4048
Synonym: (±)-Monastrol
Target: Apoptosis, Kinesin
INH1
T2502
Synonym: IBT13131
Target: Apoptosis, Microtubule Associated
Nifuroxazide
T1563
Synonym: Diarlidan,Nifuroxazid,Dicoferin
Target: Antibacterial, Antibiotic, STAT
D-JNKI-1 acetate
T10937L
Synonym: D-JNKI-1 acetate(1445179-97-4 Free base),AM-111 acetate
Target: JNK
TPPB
T17148
Synonym:
Target: PKC
PD 169316
T2432
Synonym:
Target: Virus Protease, p38 MAPK, Autophagy
Fluorescein diacetate
T19323
Synonym: 3,6-Diacetoxyfluoran,Di-O-acetylfluorescein
Target: Others
TGX-221
T2661
Synonym: TGX221
Target: PI3K
1 2 3 4 5 6 7 8 9 10
Cat No. Product Name Synonyms Targets
T4183 Lavendustin A RG-14355,NSC 678027 EGFR , Tyrosinase
lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
T2933 Wogonin Vogonin Apoptosis , Wnt/beta-catenin , CDK , Autophagy
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
T3419 Chelerythrine chloride Apoptosis , BCL , PKC , Autophagy
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
T16012 Marizomib NPI-0052,Salinosporamide A,ML858 Proteasome
Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv...
T8114 Quercetagetin 6-Hydroxyquercetin Pim
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).
T6564 Leupeptin Hemisulfate Serine Protease , Cysteine Protease
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc...
T13493 3-Acetyldeoxynivalenol Others
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin.
T13630 Cytochalasin C Others
Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice.
T29888 Aloe-emodin-glucoside
Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
TN4343 Jaceidin 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone,Quercetagetin 3,3',6-trimethyl ether,Jaceidine VEGFR , Antioxidant
Jaceidin (Quercetagetin 3,3',6-trimethyl ether) is a membrane-permeable inhibitor of VEGFR with anti-tumor activities.
T15638 K-252c PKC
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ...
T10928 Cytochalasin A HIV Protease
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu...
T14831 Bryostatin 1 HIV Protease , PKC
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.0...
T73876 Sanggenon G
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances...
T36439 Gramicidin A Antibacterial , HIF , Parasite
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01584 KRT7 Protein, Human, Recombinant (His & SUMO) Human E. coli
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
TMPH-03057 Chorismate synthase Protein, Neurospora crassa, Recombinant (His) Neurospora crassa E. coli
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys...
TMPH-01695 MLKL Protein, Human, Recombinant (His) Human Yeast
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel...
TMPH-03426 Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His) RVX Yeast
This Recombinant Rotavirus X Outer capsid protein VP4 protein was made through genetic engineering. By putting the Outer capsid protein VP4 gene into the genetic material of Yeast cell, the Yeast could be used as factori...
TMPH-01540 Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc) Human E. coli
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t...
TargetMol