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POBN

Name: POBN
Brand: TargetMol
SKU: TYD-04748
Rating: 4.5 (1 reviews)

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Catalog No. TYD-04748Cas No. 66893-81-0

Alias 4-POBN

POBN (4-POBN) is a hydrophilic trapping agent permeable to cells, useful for detecting radical adducts.

POBN

😃Good

Catalog No. TYD-04748Alias 4-POBNCas No. 66893-81-0

POBN (4-POBN) is a hydrophilic trapping agent permeable to cells, useful for detecting radical adducts.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	POBN (4-POBN) is a hydrophilic trapping agent permeable to cells, useful for detecting radical adducts.
In vitro	When POBN (20 mM) and sodium formate (100 mM) are mixed with bile in the collection tube in the presence of 2,2'-bipyridine (DP) (5 mM) and bathocuproine disulfonic acid disodium salt hydrate (BC) (5 mM), only a faint residual signal of POBN radical adducts was detected.
In vivo	After administering acute doses of sodium formate (2 g/kg) and POBN (1.5 g/kg) via intraperitoneal injection, the electron spin resonance (ESR) spectra of radical adducts were detected in the bile of rats one hour post-administration.
Synonyms	4-POBN

Chemical Properties

Molecular Weight	194.23
Formula	C₁₀H₁₄N₂O₂
Cas No.	66893-81-0
Smiles	O=N1=CC=C(C=C1)C=N(=O)C(C)(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc