Search Result

Search Results for " mitochondrial "

Targets

Mitochondrial Metabolism Mitochondrial Metabolism

482

Compounds

163

Natural Products

227

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T9232	Mitochondrial fusion promoter M1		Mitochondrial Metabolism
	Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia...		Mitochondrial Metabolism
T37657	Mitochondrial respiration-IN-1 hydrobromide
	Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1].
T1907	Mdivi-1	Mitochondrial division inhibitor 1	Apoptosis , Mitophagy , Dynamin , Autophagy
	Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.		Apoptosis , Mitophagy , Dynamin , Autophagy
T72137	Mitochondrial respiration-IN-3
	Mitochondrial respiration-IN-3, a fluorine derivative of Dalfopristin, possesses cell membrane permeability and exhibits the capability to inhibit mitochondrial translation in glioblastoma stem cells. This compound is ut...
T72138	Mitochondrial respiration-IN-2
	Mitochondrial respiration-IN-2, a fluorine derivative of Virginiamycin M1, inhibits the mitochondrial translation of glioblastoma stem cells [1].
T9372	D-Histidine		Mitochondrial Metabolism
	D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.		Mitochondrial Metabolism
T1768	7ACC2		Mitochondrial Metabolism , Monocarboxylate transporter
	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.		Mitochondrial Metabolism , Monocarboxylate transporter
T9031	MCU-i4		Others , Mitochondrial Metabolism
	MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.		Others , Mitochondrial Metabolism
T15373	Gboxin		ATPase , Mitochondrial Metabolism
	Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.		ATPase , Mitochondrial Metabolism
T9777	THP104c		Mitochondrial Metabolism
	THP104c is an inhibitor of mitochondrial fission.		Mitochondrial Metabolism
T8732	CTPI-2		Others , Mitochondrial Metabolism
	CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...		Others , Mitochondrial Metabolism
T12408	Perhexiline maleate		Others , Mitochondrial Metabolism
	Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.		Others , Mitochondrial Metabolism
T0239	Lonidamine	AF1890,DICA,Diclondazolic Acid	Apoptosis , Hexokinase , Mitochondrial Metabolism
	Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).		Apoptosis , Hexokinase , Mitochondrial Metabolism
T14497	BAM 15		OXPHOS , Mitochondrial Metabolism
	BAM 15 is an uncoupler of mitochondrial protonophore.		OXPHOS , Mitochondrial Metabolism
T15241	ER-000444793		Others , Mitochondrial Metabolism
	ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).		Others , Mitochondrial Metabolism
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T6157	Devimistat	CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis , Dehydrogenase , Mitochondrial Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...		Apoptosis , Dehydrogenase , Mitochondrial Metabolism
T10706	CCI-006		Mitochondrial Metabolism
	CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfold...		Mitochondrial Metabolism
T19428	Mito-TEMPO		Reactive Oxygen Species , Mitochondrial Metabolism
	Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO scavenges superoxide and alkyl radicals and prevents mitochondrial oxidation, necrosis and apoptosis.		Reactive Oxygen Species , Mitochondrial Metabolism
T9169	MPP+ iodide		Mitochondrial Metabolism , Autophagy
	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...		Mitochondrial Metabolism , Autophagy
T14177	Alexidine dihydrochloride		Apoptosis , Others , Antifungal
	Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, i...		Apoptosis , Others , Antifungal
T8526	Metformin	1,1-Dimethylbiguanide	Mitophagy , AMPK , Autophagy
	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...		Mitophagy , AMPK , Autophagy
T4639	Azemiglitazone	MSDC 0602	Mitochondrial Metabolism , mTOR
	Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.		Mitochondrial Metabolism , mTOR
T5337	IACS-010759	IACS-10759,IACS 10759,IACS10759	Apoptosis , Others , Mitochondrial Metabolism
	IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.		Apoptosis , Others , Mitochondrial Metabolism
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
T1554	Iohexol		Mitophagy , Autophagy
	Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood.		Mitophagy , Autophagy
T22022	Adaptaquin		HIF
	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].		HIF
T2607	MSDC 0160	CAY10415,Mitoglitazone,MSDC0160,MSDC-0160	Others , IGF-1R , Mitochondrial Metabolism
	MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.		Others , IGF-1R , Mitochondrial Metabolism
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T1940	BTB06584		RAAS , ATPase
	BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).		RAAS , ATPase
T0876	Clioquinol	Chinoform,Iodochlorhydroxyquin	Mitophagy , Antibiotic , Autophagy , Antifungal
	Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.		Mitophagy , Antibiotic , Autophagy , Antifungal
T2498	Adjudin	AF-2364	Chloride channel , Mitochondrial Metabolism
	Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.		Chloride channel , Mitochondrial Metabolism
T6641	Rilmenidine Phosphate		Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
	Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T1640	Ciprofloxacin	Ciproxan,Ciprobay,Bay o 9867,Bay-09867	Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.		Topoisomerase , Antibacterial , Antibiotic
T16342	KL1333	NQO1 activator 1	NADPH , Mitochondrial Metabolism
	KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ...		NADPH , Mitochondrial Metabolism
T39516	Bocidelpar		PPAR
	Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.		PPAR
T22043	BCATc Inhibitor 2		Others
	BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake,...		Others
T9235	GW604714X	2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-	Mitochondrial Metabolism
	GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate		Mitochondrial Metabolism
T1635	Fenchlorphos	Ronnel,Dermafos	AChE , Parasite
	Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.		AChE , Parasite
T19663	Triheptanoin	UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011	Others
	Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1.		Others
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1567	Olanzapine	LY170053	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR
	Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T0250	Ciprofloxacin monohydrochloride	Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T6834	FCCP	Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone	ATPase , Mitochondrial Metabolism
	FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.		ATPase , Mitochondrial Metabolism
T8500	VLX600		OXPHOS , Mitochondrial Metabolism , Autophagy
	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.		OXPHOS , Mitochondrial Metabolism , Autophagy
T8320	J14	J-14	Reactive Oxygen Species
	J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death		Reactive Oxygen Species
T22381	Antimalarial agent 14	4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others
	Antimalarial agent 14 (NSC-102533) is a bioactive chemical.		Others
T0740	Metformin hydrochloride	Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy , AMPK , Autophagy
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...		Mitophagy , AMPK , Autophagy

Compounds

Mitochondrial fusion promoter M1

T9232

Synonym:

Target: Mitochondrial Metabolism

Mitochondrial respiration-IN-1 hydrobromide

Synonym: Mitochondrial division inhibitor 1

Target: Apoptosis, Mitophagy, Dynamin, Autophagy

Mitochondrial respiration-IN-3

T72137

Synonym:

Target:

Mitochondrial respiration-IN-2

Target: Mitochondrial Metabolism

7ACC2

T1768

Synonym:

Target: Mitochondrial Metabolism, Monocarboxylate transporter

MCU-i4

T9031

Synonym:

Target: Others, Mitochondrial Metabolism

Gboxin

T15373

Synonym:

Target: ATPase, Mitochondrial Metabolism

THP104c

T9777

Synonym:

Target: Mitochondrial Metabolism

CTPI-2

T8732

Synonym:

Target: Others, Mitochondrial Metabolism

Perhexiline maleate

T12408

Synonym:

Target: Others, Mitochondrial Metabolism

Lonidamine

T0239

Synonym: AF1890,DICA,Diclondazolic Acid

Target: Apoptosis, Hexokinase, Mitochondrial Metabolism

BAM 15

T14497

Synonym:

Target: OXPHOS, Mitochondrial Metabolism

ER-000444793

T15241

Synonym:

Target: Others, Mitochondrial Metabolism

BI-6C9

T5827

Synonym:

Target: Apoptosis, Others, Mitochondrial Metabolism

Devimistat

T6157

Synonym: CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism

CCI-006

T10706

Synonym:

Target: Mitochondrial Metabolism

Mito-TEMPO

T19428

Synonym:

Target: Reactive Oxygen Species, Mitochondrial Metabolism

MPP+ iodide

T9169

Synonym:

Target: Mitochondrial Metabolism, Autophagy

Alexidine dihydrochloride

T14177

Synonym:

Target: Apoptosis, Others, Antifungal

Metformin

T8526

Synonym: 1,1-Dimethylbiguanide

Target: Mitophagy, AMPK, Autophagy

Azemiglitazone

T4639

Synonym: MSDC 0602

Target: Mitochondrial Metabolism, mTOR

IACS-010759

T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

Pyraclostrobin

T9491

Synonym:

Target: Antibacterial, Antifungal

Iohexol

T1554

Synonym:

Target: Mitophagy, Autophagy

Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160

Target: Others, IGF-1R, Mitochondrial Metabolism

Target: Apoptosis, PERK

Synonym: Chinoform,Iodochlorhydroxyquin

Target: Mitophagy, Antibiotic, Autophagy, Antifungal

Adjudin

T2498

Synonym: AF-2364

Target: Chloride channel, Mitochondrial Metabolism

Rilmenidine Phosphate

T6641

Synonym:

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

Ciprofloxacin

T1640

Synonym: Ciproxan,Ciprobay,Bay o 9867,Bay-09867

Target: Topoisomerase, Antibacterial, Antibiotic

KL1333

T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Target: Mitochondrial Metabolism

Fenchlorphos

T1635

Synonym: Ronnel,Dermafos

Target: AChE, Parasite

Triheptanoin

T19663

Synonym: UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Olanzapine

T1567

Synonym: LY170053

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR

BAI1

T5210

Synonym:

Target: Apoptosis, BCL

Ciprofloxacin monohydrochloride

T0250

Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

FCCP

T6834

Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone

Target: ATPase, Mitochondrial Metabolism

VLX600

T8500

Synonym:

Target: OXPHOS, Mitochondrial Metabolism, Autophagy

J14

T8320

Synonym: J-14

Target: Reactive Oxygen Species

Antimalarial agent 14

T22381

Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone

Target: Others

Metformin hydrochloride

T0740

Synonym: Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Cat No.	Product Name	Synonyms	Targets
T8433	HQNO		Mitochondrial Metabolism
	HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mitochondrial NDH-2 inhibitorin many species.		Mitochondrial Metabolism
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
TN1586	Dihydrorotenone		Apoptosis , Mitochondrial Metabolism
	Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.		Apoptosis , Mitochondrial Metabolism
T5645	Nerol	Cis-Geraniol,Neryl alcohol	Apoptosis , Reactive Oxygen Species , Mitochondrial Metabolism , Endogenous Metabolite , Antifungal
	Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
T6468	D-glutamine		Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T0595	Naringin	Naringoside	Mitophagy , P450 , Endogenous Metabolite , Autophagy
	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.		Mitophagy , P450 , Endogenous Metabolite , Autophagy
T14140	Agaric acid	Agaricinic Acid	Mitochondrial Metabolism , AChR
	Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondri...		Mitochondrial Metabolism , AChR
T7922	Kresoxim-Methyl		Others , Mitochondrial Metabolism , Antifungal
	Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .		Others , Mitochondrial Metabolism , Antifungal
T8347	Rifamycin S		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
T11685	Isolongifolene	(-)-Isolongifolene	Apoptosis , Others
	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative ...		Apoptosis , Others
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T0938	Thiabendazole	2-(4-Thiazolyl)benzimidazole	Microtubule Associated , Mitochondrial Metabolism , Parasite
	Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
T8678	Naphthazarin	5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...		Apoptosis
T2970	Rotenone	Rotenon,Paraderil,Barbasco,Rotocide,Dactinol	Apoptosis , Dehydrogenase , Mitochondrial Metabolism , p53 , Autophagy
	Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces...
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T2177	Kaempferol	Kempferol,Robigenin	Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T3410	Momordin Ic	Momordin 1c	Apoptosis , MAPK , PI3K
	Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. A...		Apoptosis , MAPK , PI3K
TN1362	Afzelin	Kaempferol-3-O-rhamnoside	PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
	Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
T3S0156	Atractyloside potassium salt	Atractyloside Dipotassium Salt	Others
	1. Atractyloside potassium salt (Atractyloside Dipotassium Salt) inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane.		Others
T6062	Brefeldin A	BFA,Ascotoxin,Cyanein,Decumbin	ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9
	Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ...
T3898	Schaftoside	APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T1659	Melatonin	Melatonine,N-Acetyl-5-methoxytryptamine	CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy
	Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin...
T0200	α-Lipoic Acid	Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid	Apoptosis , NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite
	α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme ...
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T1131	Ivermectin	MK-933	Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
	Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T2A2532	L-Histidine	Glyoxaline-5-alanine,L-(-)-Histidine,histidine,L-Hisidine	Mitochondrial Metabolism , Endogenous Metabolite
	L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect ne...		Mitochondrial Metabolism , Endogenous Metabolite
T2901	Daidzin	NPI-031D,Daidzein 7-O-glucoside,Daidzoside,Daidzein 7-glucoside	Dehydrogenase , Reverse Transcriptase , Mitochondrial Metabolism
	Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T7917	4'-Hydroxychalcone	2-Benzal-4-Hydroxyacetophenone	Proteasome
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity		Proteasome
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T0132	Etoposide	VP-16,VP-16-213	Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T2830	Betulinic acid	ALS-357,Lupatic acid,Betulic acid	Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy
	Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert...
T5564	Tricarballylic acid	β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid	aconitase , Mitochondrial Metabolism
	Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.		aconitase , Mitochondrial Metabolism
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T22235	Lipoic acid	R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid	Reactive Oxygen Species , Mitochondrial Metabolism , Endogenous Metabolite
	Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
T6290	Tanespimycin	17-AAG,CP 127374,NSC 330507,KOS 953	Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T1020	Doxorubicin hydrochloride	Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127	Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T2822	Ginsenoside Rb1	Gypenoside Ⅲ,Gypenoside III	ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
	Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.		ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
T1662	5-Aminolevulinic acid hydrochloride	Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride	Apoptosis , Mitophagy , Endogenous Metabolite , Autophagy
	5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.		Apoptosis , Mitophagy , Endogenous Metabolite , Autophagy
T8130	Ciprofloxacin hydrochloride monohydrate	Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan	Antibacterial , Antibiotic
	Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic,is an antibiotic used to treat a number of bacterial infections		Antibacterial , Antibiotic
T7064	Valproic Acid	Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T1456	Doxorubicin	Hydroxydaunorubicin,Adriamycin	Topoisomerase , AMPK
	Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.		Topoisomerase , AMPK
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
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Natural Products

HQNO

T8433

Synonym:

Target: Mitochondrial Metabolism

Liensinine

T5S1099

Synonym:

Target: Apoptosis, Mitophagy, Others, Autophagy

Dihydrorotenone

TN1586

Synonym:

Target: Apoptosis, Mitochondrial Metabolism

Nerol

T5645

Synonym: Cis-Geraniol,Neryl alcohol

Target: Apoptosis, Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite, Antifungal

D-glutamine

T6468

Synonym:

Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy

Naringin

T0595

Synonym: Naringoside

Target: Mitophagy, P450, Endogenous Metabolite, Autophagy

Agaric acid

T14140

Synonym: Agaricinic Acid

Target: Mitochondrial Metabolism, AChR

Kresoxim-Methyl

T7922

Synonym:

Target: Others, Mitochondrial Metabolism, Antifungal

Rifamycin S

T8347

Synonym:

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Polydatin

T3427

Synonym: Piceid,Polydotin Peceid

Target: Apoptosis, Mitophagy, NF-κB, Autophagy

Hemin

T5515

Synonym: Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

Isolongifolene

T11685

Synonym: (-)-Isolongifolene

Target: Apoptosis, Others

Parthenolide

T2140

Synonym: (-)-Parthenolide

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Quercetin

T2174

Synonym: Sophoretin

Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy

Thiabendazole

T0938

Synonym: 2-(4-Thiazolyl)benzimidazole

Target: Microtubule Associated, Mitochondrial Metabolism, Parasite

Tripterin

T3028

Synonym: Celastrol,Tripterine

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Naphthazarin

T8678

Synonym: 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

Target: Apoptosis

Rotenone

T2970

Synonym: Rotenon,Paraderil,Barbasco,Rotocide,Dactinol

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy

Salicylic acid

T0649

Synonym: 2-Hydroxybenzoic acid

Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy

Kaempferol

T2177

Synonym: Kempferol,Robigenin

Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy

Momordin Ic

T3410

Synonym: Momordin 1c

Target: Apoptosis, MAPK, PI3K

Afzelin

TN1362

Synonym: Kaempferol-3-O-rhamnoside

Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy

Liensinine diperchlorate

T4S1102

Synonym: Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Atractyloside potassium salt

T3S0156

Synonym: Atractyloside Dipotassium Salt

Target: Others

Brefeldin A

T6062

Synonym: BFA,Ascotoxin,Cyanein,Decumbin

Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9

Schaftoside

T3898

Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Melatonin

T1659

Synonym: Melatonine,N-Acetyl-5-methoxytryptamine

Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy

α-Lipoic Acid

T0200

Synonym: Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid

Target: Apoptosis, NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite

3-Methyladenine

T1879

Synonym: 3-MA,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Ivermectin

T1131

Synonym: MK-933

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

L-Histidine

T2A2532

Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,histidine,L-Hisidine

Target: Mitochondrial Metabolism, Endogenous Metabolite

Daidzin

T2901

Synonym: NPI-031D,Daidzein 7-O-glucoside,Daidzoside,Daidzein 7-glucoside

Target: Dehydrogenase, Reverse Transcriptase, Mitochondrial Metabolism

4'-Hydroxychalcone

T7917

Synonym: 2-Benzal-4-Hydroxyacetophenone

Target: Proteasome

Ethyl 3,4-dihydroxybenzoate

T5684

Synonym:

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Simvastatin

T0687

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

Etoposide

T0132

Synonym: VP-16,VP-16-213

Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Curcumin

T1516

Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

Betulinic acid

T2830

Synonym: ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Tricarballylic acid

T5564

Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid

Target: aconitase, Mitochondrial Metabolism

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Lipoic acid

T22235

Synonym: R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite

Tanespimycin

T6290

Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953

Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy

Doxorubicin hydrochloride

T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Ginsenoside Rb1

T2822

Synonym: Gypenoside Ⅲ,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

5-Aminolevulinic acid hydrochloride

T1662

Synonym: Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride

Target: Apoptosis, Mitophagy, Endogenous Metabolite, Autophagy

Ciprofloxacin hydrochloride monohydrate

T8130

Synonym: Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan

Target: Antibacterial, Antibiotic

Valproic Acid

T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

Doxorubicin

T1456

Synonym: Hydroxydaunorubicin,Adriamycin

Target: Topoisomerase, AMPK

Methyl protodioscin

T3771

Synonym: Smilax saponin B,NSC-698790

Target: Apoptosis

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00220	Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th...
TMPH-00265	Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)	Bovine	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX.
TMPH-01211	DGUOK Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis de...
TMPJ-00956	MDH2 Protein, Human, Recombinant (His)	Human	Human Cells
	Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofac...
TMPH-02296	C2orf69 Protein, Human, Recombinant (His)	Human	E. coli
	May play a role in the respiratory chain.
TMPH-02297	C2orf69 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	May play a role in the respiratory chain.
TMPY-02545	Aconitase 2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	A homozygous missense mutation was identified in the ACO2 gene (c.1240T>G p.Phe414Val) that segregated with HSP complicated by intellectual disability and microcephaly. Lymphoblastoid cell lines of homozygous carrier pat...
TMPY-04763	CKMT2 Protein, Rat, Recombinant (His)	Rat	E. coli

TMPJ-00313	Fumarase Protein, Human, Recombinant	Human	E. coli
	Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend...
TMPJ-01075	BDH1 Protein, Human, Recombinant (His)	Human	E. coli
	D-Beta-Hydroxybutyrate Dehydrogenase Mitochondrial (BDH) is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH is localized in the mitochondrion matrix. BDH forms a homotetrameric lipid-requiring enz...
TMPJ-00105	SOD2 Protein, Human, Recombinant (His)	Human	Human Cells
	Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic super...
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms to...
TMPY-02044	SOD2 Protein, Human, Recombinant	Human	E. coli
	Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is locat...
TMPY-04477	CKMT1A Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes that encodes the ubiquitous mitoch...
TMPY-02133	Carbonic Anhydrase VB Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, ...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST)	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by hi...
TMPY-02787	Aconitase 2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	A homozygous missense mutation was identified in the ACO2 gene (c.1240T>G p.Phe414Val) that segregated with HSP complicated by intellectual disability and microcephaly. Lymphoblastoid cell lines of homozygous carrier pat...
TMPY-03609	ATP5D Protein, Human, Recombinant (His)	Human	E. coli
	ATP5D is a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synth...
TMPY-04764	PCK2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabol...
TMPH-01202	D2HGDH Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-...
TMPY-00924	SMAC Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
TMPJ-00470	CYB5B Protein, Human, Recombinant (His)	Human	Human Cells
	Cytochrome b5 type B (CYB5B) is a membrane of the cytochrome b5 family. It contains 1 cytochrome b5 heme-binding domain. Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several mem...
TMPY-04073	MRPL44 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondria...
TMPH-02627	DHODH Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-00071	AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli

TMPJ-00941	DUTPase Protein, Human, Recombinant (His)	Human	E. coli
	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP, the immediate precurs...
TMPH-02642	ECHS1 Protein, Mouse, Recombinant (C225S, HA & His)	Mouse	Baculovirus
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcr...
TMPH-03759	ECHS1 Protein, Mouse, Recombinant (HA & His)	Mouse	E. coli
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcr...
TMPH-01225	DHODH Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-02850	DHODH Protein, Mouse, Recombinant (His)	Mouse	in vitro E. coli expression system
	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-03278	DHODH Protein, Rat, Recombinant (His)	Rat	E. coli
	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPJ-00834	ACADM Protein, Human, Recombinant (His)	Human	E. coli
	Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the m...
TMPJ-00940	DUTPase Protein, Human, Recombinant	Human	E. coli
	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP, the immediate precurs...
TMPY-01344	MAP1D Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localizatio...
TMPY-02602	PTPMT1 Protein, Human, Recombinant (His)	Human	E. coli
	PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates pho...
TMPH-00875	ACAT1 Protein, Human, Recombinant (His)	Human	E. coli
	This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleava...
TMPH-02554	BCAT2 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
TMPH-01180	COX5A Protein, Human, Recombinant (GST)	Human	E. coli
	COX5A Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-03257	CPS1 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TMPJ-01058	ARG2 Protein, Human, Recombinant (His)	Human	E. coli
	Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not found...
TMPH-01050	CPT2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential ...
TMPH-02560	CPS1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase...
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respirator...
TMPH-01037	CPS1 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TMPJ-00801	UQCRH Protein, Human, Recombinant (GST)	Human	E. coli
	Cytochrome b-c1 complex subunit 6, mitochondrial (UQCRH) belongs to the UQCRH/QCR6 family, it is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase. This is a component of the ubiquinol-cytochrom...
TMPH-00964	ATP5PB Protein, Human, Recombinant (His & Myc)	Human	E. coli
	ATP5PB Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-00718	AIF Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is t...
TMPH-00287	Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam...
TMPH-00288	Adrenodoxin reductase Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam...
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Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)

TMPH-00220

Species: Bovine

Expression System: E. coli

Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)

TMPH-00265

Species: Bovine

Expression System: E. coli

DGUOK Protein, Human, Recombinant (His & SUMO)

TMPH-01211

Species: Human

Expression System: E. coli

MDH2 Protein, Human, Recombinant (His)

TMPJ-00956

Species: Human

Expression System: Human Cells

C2orf69 Protein, Human, Recombinant (His)

TMPH-02296

Species: Human

Expression System: E. coli

C2orf69 Protein, Human, Recombinant (His & Myc)

TMPH-02297

Species: Human

Expression System: Baculovirus

Aconitase 2 Protein, Human, Recombinant (His & GST)

TMPY-02545

Species: Human

Expression System: Baculovirus-Insect Cells

CKMT2 Protein, Rat, Recombinant (His)

TMPY-04763

Species: Rat

Expression System: E. coli

Fumarase Protein, Human, Recombinant

TMPJ-00313

Species: Human

Expression System: E. coli

BDH1 Protein, Human, Recombinant (His)

TMPJ-01075

Species: Human

Expression System: E. coli

SOD2 Protein, Human, Recombinant (His)

TMPJ-00105

Species: Human

Expression System: Human Cells

SOD2 Protein, Human, Recombinant (E. coli, His)

TMPJ-00104

Species: Human

Expression System: E. coli

SOD2 Protein, Human, Recombinant

TMPY-02044

Species: Human

Expression System: E. coli

CKMT1A Protein, Human, Recombinant (His)

TMPY-04477

Species: Human

Expression System: Baculovirus-Insect Cells

Carbonic Anhydrase VB Protein, Human, Recombinant (His)

TMPY-02133

Species: Human

Expression System: E. coli

SCO1 Protein, Human, Recombinant (GST)

TMPJ-00704

Species: Human

Expression System: E. coli

Aconitase 2 Protein, Mouse, Recombinant (His & GST)

TMPY-02787

Species: Mouse

Expression System: Baculovirus-Insect Cells

ATP5D Protein, Human, Recombinant (His)

TMPY-03609

Species: Human

Expression System: E. coli

PCK2 Protein, Human, Recombinant (His & GST)

TMPY-04764

Species: Human

Expression System: Baculovirus-Insect Cells

D2HGDH Protein, Human, Recombinant (His & SUMO)

TMPH-01202

Species: Human

Expression System: E. coli

SMAC Protein, Human, Recombinant (His)

TMPY-00924

Species: Human

Expression System: E. coli

CYB5B Protein, Human, Recombinant (His)

TMPJ-00470

Species: Human

Expression System: Human Cells

MRPL44 Protein, Human, Recombinant (His)

TMPY-04073

Species: Human

Expression System: Baculovirus-Insect Cells

DHODH Protein, Mouse, Recombinant (E. coli, His)

TMPH-02627

Species: Mouse

Expression System: E. coli

AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00071

Species: Arabidopsis thaliana

Expression System: E. coli

dUTPase Protein, Human, Recombinant (His)

TMPJ-00941

Species: Human

Expression System: E. coli

ECHS1 Protein, Mouse, Recombinant (C225S, HA & His)

TMPH-02642

Species: Mouse

Expression System: Baculovirus

ECHS1 Protein, Mouse, Recombinant (HA & His)

TMPH-03759

Species: Mouse

Expression System: E. coli

DHODH Protein, Human, Recombinant (His)

TMPH-01225

Species: Human

Expression System: E. coli

DHODH Protein, Mouse, Recombinant (His)

TMPH-02850

Species: Mouse

Expression System: in vitro E. coli expression system

DHODH Protein, Rat, Recombinant (His)

TMPH-03278

Species: Rat

Expression System: E. coli

ACADM Protein, Human, Recombinant (His)

TMPJ-00834

Species: Human

Expression System: E. coli

dUTPase Protein, Human, Recombinant

TMPJ-00940

Species: Human

Expression System: E. coli

MAP1D Protein, Human, Recombinant (His)

TMPY-01344

Species: Human

Expression System: Baculovirus-Insect Cells

PTPMT1 Protein, Human, Recombinant (His)

TMPY-02602

Species: Human

Expression System: E. coli

ACAT1 Protein, Human, Recombinant (His)

TMPH-00875

Species: Human

Expression System: E. coli

BCAT2 Protein, Mouse, Recombinant (His & Myc)

TMPH-02554

Species: Mouse

Expression System: E. coli

COX5A Protein, Human, Recombinant (GST)

TMPH-01180

Species: Human

Expression System: E. coli

CPS1 Protein, Rat, Recombinant (His & Myc)

TMPH-03257

Species: Rat

Expression System: E. coli

ARG2 Protein, Human, Recombinant (His)

TMPJ-01058

Species: Human

Expression System: E. coli

CPT2 Protein, Human, Recombinant (His & Myc)

TMPH-01050

Species: Human

Expression System: E. coli

CPS1 Protein, Mouse, Recombinant (His)

TMPH-02560

Species: Mouse

Expression System: E. coli

COX5A Protein, Mouse, Recombinant (His & SUMO)

TMPH-02617

Species: Mouse

Expression System: E. coli

ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)

TMPH-02530

Species: Mouse

Expression System: E. coli

CPS1 Protein, Human, Recombinant (His)

TMPH-01037

Species: Human

Expression System: E. coli

UQCRH Protein, Human, Recombinant (GST)

TMPJ-00801

Species: Human

Expression System: E. coli

ATP5PB Protein, Human, Recombinant (His & Myc)

TMPH-00964

Species: Human

Expression System: E. coli

AIF Protein, Human, Recombinant (His)

TMPJ-00718

Species: Human

Expression System: E. coli

Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)

TMPH-00287

Species: Bovine

Expression System: E. coli

Adrenodoxin reductase Protein, Bovine, Recombinant (His)

TMPH-00288

Species: Bovine

Expression System: Yeast

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	A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
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