conjugate

Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties.

Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.

ALC-0159 is a polyethylene glycol (PEG) lipid conjugate that could be used as a vaccine excipient[1].

AZD 1775 Linker Conjugate 1 TFA is a compound involved in ubiquitinase-targeted chimeric assays

FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].

K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells [1].

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in synthesizing PROTAC K-Ras Degrader-1, a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].

K-Ras ligand-Linker Conjugate 6 is a compound that combines a K-Ras-recruiting fragment ligand and a PROTAC linker to recruit E3 ligase for the synthesis of PROTAC K-Ras Degrader-1.

E3 Ligase Ligand-linker Conjugate 125 is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker Conjugate) used for synthesizing PROTAC IRAK4degrader-12.

E3 Ligase Ligand-Linker Conjugate 135 is a critical intermediate in the synthesis of the complete PROTAC molecule pan-KRAS degrader 5, comprising a conjugate of E3 ligase ligand and linker.

E3 Ligase Ligand-linker Conjugate 146 serves as an E3 ubiquitin ligase ligand and linker for PROTAC, utilized in the synthesis of BCPyr.

E3 Ligase Ligand-linker Conjugate 142 is a conjugate comprised of an E3 ubiquitin ligase ligand and a linker, utilized in the synthesis of CFT8634.

E3 Ligase Ligand-linker Conjugate 150 is a conjugate consisting of a ligand for the E3 ligase VHL and a linker, and it is utilized in the synthesis of PROTAC SMARCA2 degrader-32.

E3 Ligase Ligand-linker Conjugate 141 is a combination of an E3 ubiquitin ligase ligand and a linker, utilized in the synthesis of PROTACER Degrader-12.

E3 Ligase Ligand-linker Conjugate 149 is an E3 ubiquitin ligase ligand-linker conjugate, and it is used in the synthesis of Setidegrasib.

E3 Ligase Ligand-linker Conjugate 151 is a conjugate of an E3 ligase ligand and a linker. It is utilized in the synthesis of PROTAC SMARCA2/4 degrader-36.

E3 Ligase Ligand-linker Conjugate 147 is a conjugate of an E3 ligase ligand and a PROTAC linker, utilized in the synthesis of BRD9 Degrader-1 (Compound 13-7). Comprising the E3 ligase ligand BRD9 ligand-7 and the PROTAC linker 2-((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)ethan-1-ol, this conjugate plays a critical role in biochemical applications.

E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugate of an E3 ligase ligand and a linker, utilized for the synthesis of the PROTAC degrader NR-11c.

E3 Ligase Ligand-linker Conjugate 143 is a compound consisting of an E3 ubiquitin ligase ligand and a linker, used for synthesizing ACBI3.

Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate made of Melatonin and Tamoxifen, serving as an effective antagonist of ERα (IC50 = 863 nM). In cells expressing the hMT1 receptor, it binds to MLT receptors (Ki = 3.1 nM) and exhibits the ability to promote β-arrestin activation (EC50 = 914 nM) and ERK activation (EC50 = 98 nM). The IC50 values for Melatonin-Tamoxifen Conjugate in MCF-7, MDA-MB-231, and HT-1080 cell lines are 6.8 μM, 6.4 μM, and 1.7 μM, respectively.