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Results for "

PDE

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    381
    TargetMol | Inhibitors_Agonists
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    3
    TargetMol | Peptide_Products
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Vesnarinone
Piteranometozine, OPC-8212, Arkin
T346581840-15-5In house
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
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Pentoxifylline
PTX, Oxpentifylline, BL-191
T00706493-05-6
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet aggregation and improves blood flow by increasing erythrocyte and leukocyte flexibility.
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Vinpocetine
RGH-4405, Ethyl apovincaminate
T016742971-09-5
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
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Doxofylline
Doxophylline
T048069975-86-6
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.
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Theophylline monohydrate
Quibron
T1083L5967-84-0
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
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Amrinone
Wincoram, Inocor, Inamrinone
T126560719-84-8
Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
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Dipyridamole
Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol
T161858-32-2
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
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Ibudilast
MN-166, KC-404, AV-411
T213750847-11-5
Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.
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Proxyphylline
7-(2-Hydroxypropyl)theophylline
T5940603-00-9
Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1 A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.
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Trapidil
Trapymine, Trapymin, Rocornal, Avantrin, AR-12008
T008015421-84-8
Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.
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5-Bromoimidazo[1,2-A]Pyrazine
T7764187597-26-0
5-Bromoimidazo[1,2-a]pyrazine inhibits phosphodiesterase and beta-adrenergic receptors.5-Bromoimidazo[1,2-a]pyrazine shows antibronchospastic activity in vitro.
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ITI-214
ITI214
T116891642303-38-5
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
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Moracin M
TN195056317-21-6
Moracin M, a phenolic compound found in the skin of Morus alba Linn., effectively inhibits phosphodiesterase-4 (PDE4), exhibiting IC50 values of 2.9 μM and 4.5 μM for PDE4D2 and PDE4B2, respectively, and showing significantly lesser activity on PDE5A1 and PDE9A2 with values over 40 μM and 100 μM, respectively. This compound demonstrates notable anti-inflammatory activity.
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7-10 days
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Robustine
TN21592255-50-7
Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.
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norbraylin
TN466560796-64-7
Norbraylin is a natural product from Toddalia asiatica.
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PDE IV-IN-1
T10201225100-12-9In house
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease and other inflammatory diseases, and is a potential compound for the study of depression.
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6-8 weeks
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Tiflucarbine
Tiflucarbina
T6816289875-86-5In house
Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of soluble calmodulin (CaM)-dependent phosphodiesterase in rat brain.
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WAY-313170
T77603314041-83-3
WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.
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PDE-9 inhibitor
T123891082743-70-1
PDE-9 inhibitor is used for treatment neurodegenerative diseases.
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6-8 weeks
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PDE-I2
T6819198296-23-2
PDE-I2 is a parasite schizogony inhibitor.
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10-14 weeks
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pde9-in-(s)-c33
T283522066488-39-7
PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.
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8-10 weeks
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pde7-in-2
T22491107522-19-0
PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.
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6-8 weeks
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PDE9-IN-1
T123952305087-92-5In house
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
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6-8 weeks
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PDE4B-IN-2
A 33
T36832915082-52-9
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
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6-8 weeks
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