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Cat No. | Product Name | Synonyms | Targets |
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T10201 | PDE IV-IN-1 | PDE | |
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease and other inflammatory diseases, and is a potential compound... | |||
T68191 | PDE-I2 | ||
PDE-I2 is a parasite schizogony inhibitor. | |||
T12389 | PDE-9 inhibitor | Others | |
PDE-9 inhibitor is used for treatment neurodegenerative diseases. | |||
T21965 | MBCQ | PDE | |
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5. | |||
T5411 | PDE10-IN-1 | SEP-0372814 | PDE |
PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders. | |||
T6462 | Deltarasin | PDE , Ras | |
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. | |||
T6054 | GSK256066 | PDE | |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. | |||
T12395 | PDE9-IN-1 | PDE | |
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM). | |||
T2129 | Zaprinast | PDE | |
Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a... | |||
T10676 | Carbodenafil | PDE | |
Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM). | |||
T4695 | CP671305 | PDE | |
CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D. | |||
T7888 | Enpp-1-IN-1 | PDE | |
Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) | |||
T3631 | PF-8380 | PDE | |
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib... | |||
T4462 | Roflumilast N-oxide | PDE | |
Roflumilast N-oxide is an inhibitor of PDE type 4. | |||
T10410 | ATX inhibitor 1 | PDE | |
ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP). | |||
T1618 | Dipyridamole | Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine | PDE |
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation. | |||
T12267 | NSP-805 | PDE | |
NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor. | |||
T5106 | BRL-50481 | PDE | |
BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively. | |||
T2646 | HA130 | PDE | |
HA130 is a selective ATX (autotaxin) inhibitor. | |||
T13448 | (R)-(-)-Rolipram | (R)-Rolipram,(-)-Rolipram | DNA-PK , Others |
(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor. | |||
T12150 | N-Methylbenzamide | PDE | |
N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity. | |||
T5474 | D159687 | D 159687 | PDE |
D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit. | |||
T7346 | Lodenafil | Hydroxyhomosildenafil | PDE |
Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED) | |||
T4041 | Ziritaxestat | GLPG1690 | PDE |
Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients. | |||
T27172 | Difamilast | PDE | |
Difamilast is an inhibitor of phosphodiesterase IV. | |||
T8515 | Osoresnontrine | BI-409306 | PDE |
Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory. | |||
T12913 | Siguazodan | SKF 94836 | PDE |
Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenylephrine induced 5-HT release with an IC50 value of 4.2 μM。 S... | |||
T1096 | Milrinone | Win 47203 | PDE |
Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor. | |||
T8405 | Vardenafil hydrochloride | PDE | |
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes | |||
T6548 | Irsogladine | Dicloguamine | PDE , AChR |
Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. | |||
T10590 | Zatolmilast | BPN14770 | Others , PDE |
Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). | |||
T23154 | Piclamilast | RPR 73401,RP 73401 | PDE |
Piclamilast (RP 73401) is a PDE4 inhibitor. | |||
T6147 | Nortadalafil | Demethyl Tadalafil | PDE |
Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio. | |||
T16499 | Mardepodect | PF-2545920 | PDE |
Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodie... | |||
T36832 | PDE4B-IN-2 | A 33 | PDE |
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects. | |||
T21865 | BC 11-38 | PDE | |
BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM). | |||
T8919 | Homo Sildenafil | PDE | |
Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor. | |||
T8659 | K-Ras-PDEδ-IN-1 | PDE | |
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM). | |||
T7542 | Amino Tadalafil | PDE | |
Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor. | |||
T8506 | THPP-1 | PDE | |
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). | |||
T5033 | Olprinone | Loprinone | PDE |
Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ... | |||
T11689 | ITI-214 | ITI214 | PDE |
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ... | |||
T5101 | BW-A 78U | BW-A78U | PDE |
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release. | |||
T9805 | BAY 2666605 | PDE | |
BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects. | |||
T1745 | Balipodect | TAK063,TAK-063,TAK 063 | PDE |
Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs. | |||
T15381 | Gisadenafil | UK-369003 | PDE |
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP. | |||
T5956 | VP3.15 dihydrobromide | GSK-3 , PDE | |
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.) | |||
T7642 | Cilostamide | OPC3689 | PDE |
Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively) | |||
T9816 | Arofylline | LAS 31025 | PDE |
Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies. | |||
T2137 | Ibudilast | AV-411,KC-404,MN-166 | PDE |
Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1266 | 3-O-Methylquercetin | IL Receptor , cAMP , PDE | |
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr... | |||
T8787 | Drotaverine hydrochloride | PDE | |
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... | |||
T1681 | Aminophylline | Phyllocontin | PDE , Adenosine Receptor |
Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect. | |||
TN1416 | Ayanin | IL Receptor , P450 , PARP , PDE | |
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio... | |||
T7027 | EURYCOMANONE | Pasakbumin A | Others |
Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p... | |||
T0892 | Diphylline | Dyphylline,Diprophylline | PDE , Adenosine Receptor |
Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodies... | |||
T2855 | Icariin | Ieariline | PDE , PPAR , Autophagy |
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator. | |||
T3783 | Fraxin | Fraxoside,Fraxetin-8-O-glucoside,Paviin | OAT , transporter , PDE |
Fraxin (Fraxoside) is a glucoside of fraxetin. | |||
T0480 | Doxofylline | Doxophylline | PDE , Adenosine Receptor |
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s... | |||
TN2159 | Robustine | PDE | |
Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. | |||
T1083 | Theophylline | Theo-24,1,3-Dimethylxanthine | Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy |
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3... | |||
T6427 | Butein | 2’,3,4,4’-tetrahydroxy Chalcone | Apoptosis , EGFR , Others , PDE , Autophagy |
Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR. | |||
T2205 | Acefylline | Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid | TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor |
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help... | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
T5S2059 | Glaucine | Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE | |
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... | |||
T0070 | Pentoxifylline | Oxpentifylline,PTX,BL-191 | HIV Protease , PDE , Adenosine Receptor , Autophagy |
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ... | |||
T17199 | Udenafil | PDE | |
Udenafil is an inhibitor of PDE5 . | |||
TN2217 | Sophoflavescenol | Others , Beta-Secretase , BACE , PDE , AChR , AChE | |
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho... | |||
T5940 | Proxyphylline | 7-(2-Hydroxypropyl)theophylline | PDE , Adenosine Receptor |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator. | |||
TN2974 | 3-O-Methylquercetin tetraacetate | IL Receptor , TNF , PDE | |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness. | |||
TN4317 | Isopedicin | NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE | |
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE. | |||
TN4398 | Kushenol B | Others | |
Kushenol B is a natural product for research related to life sciences. The catalog number is TN4398 and the CAS number is 99217-64-8. | |||
T16397 | Ophiobolin A | Others | |
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and antica... |
Cat No. | Product Name | Species | Expression System |
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TMPY-02081 | PDE2A Protein, Human, Recombinant (aa 215-900, His) | Human | Baculovirus-Insect Cells |
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub... | |||
TMPY-01588 | ALDH7A1 Protein, Human, Recombinant (His) | Human | E. coli |
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol... | |||
TMPY-01819 | PDE1B Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho... | |||
TMPY-01922 | PDE9A Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br... | |||
TMPY-01921 | PDE9A Protein, Human, Recombinant (His) | Human | E. coli |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br... | |||
TMPH-02575 | PDE5A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t... | |||
TMPH-03254 | PDE1C Protein, Rat, Recombinant (His) | Rat | E. coli |
Inhibits a wide variety of beta lactamases. | |||
TMPH-01467 | PDE9A Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the ... | |||
TMPY-02977 | PDE1C Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ... | |||
TMPH-02706 | PDE9A Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Required for extrapulmonary dissemination. Mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells. |