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Results for "

integrin

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    230
    TargetMol | Inhibitors_Agonists
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    69
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    TargetMol | Inhibitors_Agonists
SB273005
T6657205678-31-5In house
SB273005 is an orally active and potent nonpeptide integrin αvβ3 antagonist that inhibits αvβ3 and αvβ5 and reduces the production of Th2 cells and the cytokine IL-10 in pregnant mice.
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4-6 weeks
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Cilengitide
EMD 121974
T2494188968-51-6
Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3 5 receptor (IC50: 4.1 79 nM, in cell-free assays) with approximately 10-fold selectivity against gpIIbIIIa.
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TargetMol | Inhibitor Sale
ATN-161 trifluoroacetate salt
ATN-161 TFA salt
T10397904763-27-5
ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.
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Natalizumab
T12177189261-10-7
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
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Leukadherin-1
T3638344897-95-6
Leukadherin-1 is an allosteric activator of CD11b CD18. Increasing CD11b CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.
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Fibronectin
T4096086088-83-7
Fibronectin is a macromolecular glycoprotein found in blood, connective tissue, and cell surfaces that serves as a biomarker for tissue damage.Fibronectin is recognized by the integrin family of surface receptors.Fibronectin is used in the study of primary open-angle glaucoma.Fibronectin is used in the study of primary open-angle glaucoma.Fibronectin is used in the study of metastatic prostat
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7-10 days
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ilk-in-2
OSU-T315
T54881333146-24-9
ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
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Abrilumab
MEDI-7183, MEDI7183, AMG-181, AMG181
T767371342290-43-0
Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin and can be used to study inflammatory bowel disease and ulcerative colitis.
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Efalizumab
Hu1124, HU 1124
T76924214745-43-4
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis.
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Tadocizumab
YM-337, YM337, C4G1, C4G 1
T76979339086-80-5
Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic activity that blocks the platelet αIIbβ3 integrin interac- with brinogen and bronectin, and can be used in the study of cardiovascular disease.
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Etrolizumab
rhuMAb Beta7, RG7413, RG 7413, PRO145223, PRO 145223
T771541044758-60-2
Etrolizumab (rhuMAb Beta7) is a humanized intestinal-selective anti-β7 integrin monoclonal antibody that selectively blocks the transport and retention of lymphocytes in the intestinal tract for the study of inflammatory bowel disease (IBD).
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αvβ6 integrin inhibitor 2
T79140313709-47-6
αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.
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8-10 weeks
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αvβ1 integrin-IN-2
T797922234874-68-9
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. This compound also inhibits other integrins with IC50 values of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), and 87 nM (ανβ8), as determined by the SPRA assay [1].
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8-10 weeks
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α7β1 integrin modulator-1
T79918849121-82-0
α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].
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8-10 weeks
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Vedolizumab
T9914943609-66-3
Vedolizumab, a humanized monoclonal antibody, targets the α4β7 integrin for treating Crohn's disease and ulcerative colitis.
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αvβ1 integrin-IN-1
T134731689540-62-2In house
αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.
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8-10 weeks
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α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (134580-64-6)
TP1484L
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor. α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells.
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TargetMol | Inhibitor Sale
αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA
T13473L
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
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6-8 weeks
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PND-1186
VS-4718, SR-2516, PND1186, PND 1186
T19501061353-68-1
PND-1186 (VS-4718) is a specific and reversible FAK inhibitor with an IC50 of 1.5 nM.
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TargetMol | Inhibitor Hot
Integrin-IN-2
T116632378617-67-3
Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
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6-8 weeks
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Integrin Antagonists 27
T15584593274-97-6
Integrin Antagonists 27, a small molecule integrin αvβ3 antagonist with a binding affinity of 18 nM, serves as a novel anticancer agent.
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8-10 weeks
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Integrin modulator 1
T362912023788-32-9
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1, and increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].
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6-8 weeks
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αvβ5 integrin-in-1
T402432615912-33-7
αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.
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Integrin Binding Peptide
T40361278792-07-7
Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.
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