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KOdiA-PC

Name: KOdiA-PC
Brand: TargetMol
SKU: T36172
Rating: 4.5 (1 reviews)

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Catalog No. T36172Cas No. 439904-33-3

KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.

KOdiA-PC

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Catalog No. T36172Cas No. 439904-33-3

KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$198	35 days	35 days
1 mg	$388	35 days	35 days
5 mg	$1,430	35 days	35 days
10 mg	$2,560	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.
In vitro	KOdiA-PC inhibited LPS-induced macrophage migration. [1]
In vivo	In a mouse model of acute lung injury induced by intranasal injection of HKSA, intravenous injection of KOdiA-PC(10 mg/kg) increased HKSA-induced BAL protein content and cell count, as well as tissue expression of TNF-α, KC, IL1β and CCL2. And promoted blood vessel leakage in Evans Blue's lung infiltration monitoring. [2]

Chemical Properties

Molecular Weight	663.78
Formula	C₃₂H₅₈NO₁₁P
Cas No.	439904-33-3
Smiles	[C@H](OC(CCCC(/C=C/C(O)=O)=O)=O)(COP(OCC[N+](C)(C)C)(=O)[O-])COC(CCCCCCCCCCCCCCC)=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH7.2): 5 mg/mL (7.53 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

PBS (pH 7.2): 1 mg/mL (1.51 mM), Sonication is recommended.

Ethanol: 10 mg/mL (15.07 mM), Sonication is recommended.

DMF: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

PBS (pH7.2)/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.3013 mL	1.5065 mL	3.0130 mL	15.0652 mL

Ethanol

	1mg	5mg	10mg	50mg
10 mM	0.1507 mL	0.7533 mL	1.5065 mL	7.5326 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc