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Cat No. | Product Name | Synonyms | Targets |
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T78360 | Glyceraldehyde phosphate dehydrogenase | GAPDH,G3PDH,GADPH | |
Glyceraldehyde phosphate dehydrogenase, targeted by anti-thymocyte and anti-apoptotic agents, catalyzes the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by perhydroxyl radicals [1] [2]. | |||
T76174 | Isocitrate dehydrogenase | ||
Isocitrate dehydrogenase (ICDH), a critical enzyme in the citric acid or tricarboxylic acid cycle, facilitates the oxidative decarboxylation of isocitrate to α-ketoglutarate while reducing NAD(P)+ to NAD(P)H, thus playin... | |||
T76147 | 3α-Hydroxysteroid dehydrogenase | ||
3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivatio... | |||
T76118 | Malate dehydrogenase | ||
Malate dehydrogenase catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes [1] . | |||
T78350 | Glutamate dehydrogenase | ||
Glutamate dehydrogenase, an enzyme found in prokaryotes and eukaryotic mitochondria, facilitates the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate, and urease [1]. | |||
T76108 | Leucine dehydrogenase | ||
Leucine dehydrogenase, purified from Bacillus spheroides, catalyzes the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine and the reductive amination of thei... | |||
T76149 | Formate dehydrogenase | ||
Formate dehydrogenase, a widely present enzyme in both prokaryotes and eukaryotes, facilitates the reversible oxidation of formate to carbon dioxide. Based on its metal content, structure, and catalytic approach, it is c... | |||
T76099 | Alcohol dehydrogenase | ||
Alcohol dehydrogenase, a dimeric protein located in the cytosol of cells, serves as the primary enzyme for metabolizing alcohol in the body, with its highest expression in the liver. It plays a crucial role in the detoxi... | |||
T76106 | Glycerol phosphate dehydrogenase | ||
Glycerol phosphate dehydrogenase catalyzes the conversion of dihydroxyacetone phosphate to α-glycerol phosphate [1] . | |||
T76206 | Beta-Galactose dehydrogenase | ||
Beta-Galactose dehydrogenase catalyzes the conversion of galactose into galactonolactone, simultaneously reducing NAD to fluorescent NADH. This enzyme is useful for the determination of galactose [1]. | |||
T76175 | 3-Hydroxybutyrate dehydrogenase | ||
3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, plays a crucial role in the metabolism of ketone bodies and butanoate, catalyzing the conversion of (R)-3-hydroxybutanoate into acetoacetate [1]. This enz... | |||
T76207 | Glucose dehydrogenase (GDH) | ||
Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NAD... | |||
T75393 | Glucose 1-dehydrogenase | ||
Glucose 1-dehydrogenase, also known as glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase, is an enzyme that catalyzes the conversion of glucose and NAD(P) into NAD(P)H and gluconic acid, serving as a cofactor... | |||
T76116 | L-Lactate dehydrogenase | ||
L-Lactate dehydrogenase, a redox enzyme, catalyzes the in vivo reduction of pyruvate to L-lactate with absolute enantiospecificity by utilizing NADH [1]. | |||
T76146 | D-Lactate dehydrogenase | ||
D-Lactate dehydrogenase (D-LDH), an oxidoreductase, catalyzes the oxidation of D-lactate to pyruvate leveraging NAD+ or NADP+ as acceptors and acting on the donor CH-OH group. Predominantly found in bacteria and fungi, i... | |||
T73896 | Glucose-6-phosphate dehydrogenase | ||
Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such a... | |||
T73616 | Glutamate dehydrogenase (NAD(P)) | ||
Glutamate dehydrogenase NAD(P) (GLDH), a mitochondrial enzyme located in hepatocytes, renal tissue, brain, muscle, and intestinal cells, catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-K... | |||
T76159 | Aldehyde dehydrogenase (NAD(P)) | ||
Aldehyde dehydrogenase NAD(P) (ALDH) is an enzyme that facilitates the conversion of aldehydes into their respective carboxylic acids while simultaneously reducing the cofactor NAD(P) to NAD(P)H, making it a key componen... | |||
T11546 | HDHODH-IN-1 | Dehydrogenase | |
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect. | |||
T15435 | GSK2837808A | Dehydrogenase | |
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively). | |||
T39280 | Nitrofen | Others | |
Nitrofen is a selective contact herbicide. Nitrofen is a protoporphyrinogen oxidase and retinal dehydrogenase inhibitor. | |||
T7835 | CM10 | CM 10 | Dehydrogenase |
CM10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor. | |||
T11829 | LDH-IN-1 | Dehydrogenase | |
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively). | |||
T7741 | DS-1001b | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1) | |||
T12196 | NCT-505 | Dehydrogenase | |
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively... | |||
T15550 | IDH-305 | Dehydrogenase | |
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (... | |||
T6903 | NCT-501 | NCT501 | Dehydrogenase |
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. | |||
TQ0042 | BAY-1436032 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). | |||
T15827 | LY 345899 | DHFR | |
LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1). | |||
T15551 | IDH889 | Dehydrogenase | |
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt). | |||
T16161 | Mutant IDH1 inhibitor | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM). | |||
T2662 | Alda-1 | Alda 1 | Apoptosis , Dehydrogenase |
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). | |||
T2346 | Enasidenib | AG-221 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. | |||
T9394 | CHIKV-IN-2 | Dehydrogenase | |
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effec... | |||
T40168 | DHODH-IN-16 | Dehydrogenase | |
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human). | |||
T1809 | AGI-6780 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant. | |||
T11765 | KPLH1130 | Dehydrogenase , PDK | |
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions. | |||
T17224 | VER-246608 | Dehydrogenase , PDK | |
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an... | |||
T22336 | Galloflavin | Dehydrogenase | |
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent. | |||
T10140 | 4-Diethylaminobenzaldehyde | Dehydrogenase | |
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μM). | |||
T14501 | BAY-2402234 | Dehydrogenase , DNA/RNA Synthesis | |
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. | |||
T23533 | WIN 18446 | Dehydrogenase | |
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) | |||
T2447 | AZD7545 | Dehydrogenase | |
AZD7545 is a potent PDHK inhibitor. | |||
T22350 | JX06 | Apoptosis , Dehydrogenase , PDK | |
JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively. | |||
T4295 | (R)-GNE-140 | GNE-140 | Dehydrogenase |
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. | |||
T9121 | AG-636 | Dehydrogenase , DNA/RNA Synthesis | |
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects. | |||
T8767 | PfDHODH-IN-2 | Dehydrogenase , Parasite | |
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m... | |||
T16384 | Olutasidenib | FT-2102 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso... | |||
T12128 | Mutant IDH1-IN-2 | Isocitrate Dehydrogenase (IDH) | |
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor | |||
T11020 | DHODH-IN-11 | Dehydrogenase , DNA/RNA Synthesis | |
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4778 | 3-Hydroxybenzaldehyde | Others , Dehydrogenase | |
3-Hydroxybenzaldehyde is a compound useful in organic synthesis. | |||
T5705 | Glomeratose A | Dehydrogenase | |
Glomeratose A is a lactate dehydrogenase inhibitor. | |||
TJS1382 | Taraxerone | Dehydrogenase | |
Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration with the concentration dep... | |||
T0809 | Dicoumarol | Dicumarol | Dehydrogenase , NADPH , PDK |
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T3604 | Sodium dichloroacetate | Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA) | Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK |
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann... | |||
T4886 | Dihydrouracil | 5,6-Dihydrouracil | Endogenous Metabolite |
5,6-Dihydrouracil (5,6-Dihydrouracil) is an intermediate breakdown product of uracil. | |||
T7964 | Isomalt | Palatinitol,Palatinit | Others , Dehydrogenase |
Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside | |||
T10148 | 4-Hydroxynonenal | 4-HNE | Dehydrogenase , Endogenous Metabolite |
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). | |||
T5S0620 | 3-Dehydrotrametenolic acid | Dehydrotrametenolic acid | Apoptosis , Others , Dehydrogenase |
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. | |||
T1335 | Mycophenolic acid | Mycophenolate,RS-61443 | Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal |
Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity. | |||
T2207 | Adrenosterone | 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G | Androgen Receptor , Endogenous Metabolite |
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex. | |||
T3019 | Physcion | Physcione,Parietin,Rheochrysidin | Dehydrogenase , Antibacterial |
Physcion (Physcione) (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM... | |||
T4738 | Sodium 2-hydroxybutanoate | 2-Hydroxybutyric acid sodium salt,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE | Others , Endogenous Metabolite |
Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH... | |||
T21213 | Benzylurea | AI3-61350,Benzylcarbamide,Phenylmethylurea,1-Benzylurea,N-Benzylurea | Others |
Benzylurea (AI3-61350) competitively inhibits dehydrogenase/cytokinin oxidase. | |||
T5695 | Dimethyl malonate | Others | |
Dimethyl Malonate is a Succinate Dehydrogenase inhibitor. | |||
T4879 | 12-Hydroxydodecanoic acid | 12-hydroxylauric acid | Others , Endogenous Metabolite |
12-Hydroxydodecanoic acid (12-hydroxylauric acid) is the substrate of the human glutathione-dependent formaldehyde dehydrogenase. | |||
T10943 | D-(-)-Lactic acid | (R)-2-Hydroxypropionic acid | Others , Endogenous Metabolite |
D-(-)-Lactic acid is a normal intermediate in sugar fermentation (oxidation, metabolism). It is identified as a competitive inhibitor of ProDH (proline dehydrogenase) in plants. | |||
T0200 | α-Lipoic Acid | Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid | Apoptosis , NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite |
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme ... | |||
T19343L | Glycerol 3-phosphate biscyclohexylammonium salt | Endogenous Metabolite | |
Glycerol 3-phosphate biscyclohexylammonium salt is an endogenous metabolite produced by cytosolic glycerol 3-phosphate dehydrogenase pathway. | |||
T3009 | 3-Nitropropanoic acid | 3-NP acid,Bovinocidin,3-NP,β-Nitropropionic acid | Apoptosis , Dehydrogenase , Antibacterial |
3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase. | |||
TN1829 | Kakkalide | Dehydrogenase | |
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects. | |||
T5S2195 | Sibiricose A5 | Dehydrogenase | |
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia. | |||
TQ0190 | D-Xylulose | Others , Endogenous Metabolite | |
D-Xylulose is converted from xylitol by the enzyme NAD+-linked xylitol dehydrogenase in the glucuronate pathway, the most important xylitol-handling metabolic pathway in mammals. | |||
T19343 | Sn-Glycerol 3-phosphate | Glycerol 3-phosphate,sn-Glycerol 3-phosphate lithium salt | Endogenous Metabolite |
sn-Glycerol 3-phosphate is produced by the reduction of dihydroxyacetone phosphate by NADH formed during glycolysis of the cytoplasmic glycerol 3-phosphate dehydrogenase pathway. | |||
T2S2211 | Tenuifoliside C | Dehydrogenase | |
Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1]. | |||
T17048 | Tetradecanoylcarnitine | L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine | Endogenous Metabolite |
Tetradecanoylcarnitine (L-Myristoylcarnitine) is an acylcarnitine involved in the beta-oxidation of long-chain fatty acids, and is a potential marker for very-long-chain coenzyme A dehydrogenase deficiency. alpha-Dihydro... | |||
TN2373 | (E/Z)-Ginkgolic acid C17:2 | Ginkgolic Acid C17:2 | Dehydrogenase |
(E/Z)-Ginkgolic acid C17:2 (Ginkgolic Acid C17:2) is a natural product that can be extracted from Ginkgo biloba and targets human dihydroorotic acid dehydrogenase (DHODH). | |||
T6293 | Mycophenolate Mofetil | TM-MMF,RS 61443 | Apoptosis , Dehydrogenase , Drug Metabolite |
Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH). | |||
T6518 | Gossypol | Pogosin,BL 193,NSC 56817 | BCL , Dehydrogenase |
Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. | |||
T8198 | Visnagin | Others | |
Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. | |||
TN1182 | 11-Keto-beta-boswellic acid | 11-Keto-beta-boswellic acid | Leukotriene Receptor , NF-κB , Lipoxygenase |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas... | |||
T4734 | Suberic acid | Octanedioic acid,1,8-Octanedioic acid | Others , Endogenous Metabolite |
Suberic acid (1,8-Octanedioic acid) is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid ar... | |||
T5216 | Calcium L-Threonate | L-Threonic acid Calcium Salt | Others , Endogenous Metabolite |
Calcium L-Threonate (L-Threonic acid Calcium Saltr) is probably derived from glycated proteins or from the degradation of ascorbic acid. Calcium L-Threonate is a normal component is aqeous humour and blood. Calcium L-Thr... | |||
T5702 | Tenuifoliside B | Dehydrogenase | |
Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassi... | |||
T0522 | Diammonium Glycyrrhizinate | Glycyrrhizin | Dehydrogenase |
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and ... | |||
T4916 | D-Glucaric acid potassium | D-Saccharic acid potassium salt,Glucosaccharic acid,Glucaric Acid | Others , Endogenous Metabolite |
D-Glucaric acid potassium (D-Saccharic acid potassium salt) is a compound formed from oxidizing sugars, which can be used to test for the presence of hepatic enzyme induction. Studies indicate that D-glucuronolactone deh... | |||
TJS0341 | 7-Amino-4-(trifluoromethyl)coumarin | Coumarin 151,AFC | 5-HT Receptor |
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. 7-Amino-4-(trifluorometh... | |||
T5291 | Malonic acid | Carboxyacetic Acid,1,3-Propanedioic Acid,Propanedioic Acid | Others |
Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associa... | |||
T14001 | 11-Beta-hydroxyandrostenedione | NSC-17102,4-Androsten-11β-ol-3,17-dione | Endogenous Metabolite |
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozyme... | |||
T4728 | 4-Acetamidobutanoic acid | N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID | GABA Receptor , Endogenous Metabolite , Antibacterial |
4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) can be found in blood, feces, and urine, as well as in human prostate tissue. 4-Acetamidobutanoic acid exists in all eukaryotes, ranging from yeast to humans. 4-Acetamid... | |||
T4920 | 2-Ketoglutaric acid Sodium | Oxoglutaric acid,AKG,2-oxoglutarate monobasic,α-Ketoglutaric acid sodium salt | Tyrosinase , Endogenous Metabolite |
2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination... | |||
T4685 | INOSINIC ACID | Inosine 5′-monophosphate,IMP,I-5'-P | Endogenous Metabolite |
Inosinic acid (IMP) is a purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the... | |||
T5279 | Ethylmalonic acid | alpha-Carboxybutyrate,2-Ethylmalonic acid | Others , Endogenous Metabolite |
Ethylmalonic acid (alpha-Carboxybutyrate) can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be as... | |||
T5215 | N-(3-Phenylpropionyl)glycine | Phenylpropionylglycine | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors... | |||
T4867 | Erucic acid | Prifac 2990,13(Z)-Docosenoic Acid,cis-13-docosenoic acid | PI3K , Endogenous Metabolite |
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain... | |||
T5290 | (S)-2-Hydroxy-3-phenylpropanoic acid | L-(−)-3-Phenyllactic acid | Others , Endogenous Metabolite |
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The ... | |||
T4862 | Oxaloacetic acid | Endogenous Metabolite | |
Oxaloacetic acid, also known as oxosuccinic acid or oxalacetic acid, is a four-carbon dicarboxylic acid appearing as an intermediate of the citric acid cycle. In vivo, oxaloacetate (the ionized form of oxaloacetic acid) ... | |||
T4918 | DL-Glyceraldehyde | Glyceric aldehyde | Reductase |
DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ... | |||
T4880 | L-Dihydroorotic acid | Others , Endogenous Metabolite | |
L-Dihydroorotic acid, also known as (S)-4,5-dihydroorotate or dihydro-L-orotate, belongs to the class of organic compounds known as alpha amino acids and derivatives. Within the cell, L-dihydroorotic acid is primarily lo... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02398 | ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His) | Legionella pneumophila | E. coli |
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. | |||
TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli |
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as... | |||
TMPY-05357 | GCDH Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
TMPH-00405 | Acyl-CoA dehydrogenase Protein, Clostridium acetobutylicum, Recombinant (His & Myc) | Clostridium acetobutylicum | E. coli |
Acyl-CoA dehydrogenase Protein, Clostridium acetobutylicum, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-03755 | Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His) | Human | E. coli |
GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encode... | |||
TMPY-02413 | Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) | Human | E. coli |
TMPY-03407 | NQO1 Protein, Human, Recombinant (His) | Human | E. coli |
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-... | |||
TMPY-02801 | PHGDH Protein, Human, Recombinant (His) | Human | E. coli |
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the ... | |||
TMPJ-00524 | SORD Protein, Human, Recombinant (His) | Human | Human Cells |
Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expresse... | |||
TMPY-02422 | PGD Protein, Human, Recombinant (His) | Human | E. coli |
TMPY-04241 | LDHA Protein, Rat, Recombinant (His) | Rat | E. coli |
LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA, a key enzyme r... | |||
TMPH-00916 | ADH1B Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
ADH1B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00953 | ADH7 Protein, Human, Recombinant (His) | Human | Human Cells |
Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) is a cytoplasm enzyme which is a member of the alcohol dehydrogenase family. The expression of this gene makes it much more abundant in the stomach than the liver, thus... | |||
TMPH-00073 | ADH2 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
Plays a central role in formaldehyde detoxification. | |||
TMPH-00912 | ADH5 Protein, Human, Recombinant (GST) | Human | E. coli |
ADH5 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPJ-01075 | BDH1 Protein, Human, Recombinant (His) | Human | E. coli |
D-Beta-Hydroxybutyrate Dehydrogenase Mitochondrial (BDH) is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH is localized in the mitochondrion matrix. BDH forms a homotetrameric lipid-requiring enz... | |||
TMPH-00917 | ADH4 Protein, Human, Recombinant (GST) | Human | E. coli |
ADH4 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPJ-00463 | BDH2 Protein, Human, Recombinant (His) | Human | E. coli |
3-Hydroxybutyrate Dehydrogenase Type 2 belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-Hydroxybutyrate Dehydrogenase Type 2 may play an important role in the peripheral utilization of 3-hydroxybutyra... | |||
TMPJ-00955 | MDH1 Protein, Human, Recombinant (His) | Human | E. coli |
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate... | |||
TMPH-02149 | ALDH5A1 Protein, Human, Recombinant (His) | Human | Yeast |
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). | |||
TMPH-00417 | 4HbD Protein, Clostridium kluyveri, Recombinant (His & Myc) | Clostridium kluyveri | E. coli |
4HbD Protein, Clostridium kluyveri, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-04445 | PDK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient... | |||
TMPJ-00956 | MDH2 Protein, Human, Recombinant (His) | Human | Human Cells |
Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofac... | |||
TMPJ-00710 | ALDH1A2 Protein, Human, Recombinant (His) | Human | E. coli |
Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A... | |||
TMPH-03584 | Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) | Staphylococcus epidermidis | E. coli |
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also u... | |||
TMPJ-00836 | G6PD Protein, Human, Recombinant (His) | Human | Human Cells |
Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by ... | |||
TMPY-00506 | GAPDH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate... | |||
TMPY-02599 | MDH1 Protein, Rat, Recombinant (His) | Rat | E. coli |
Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramer... | |||
TMPY-05066 | IVD Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
IVD (Isovaleryl-CoA Dehydrogenase) is a Protein Coding gene. IVD is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. IVD plays an essential role in processing proteins obtained from the ... | |||
TMPH-00312 | Malate dehydrogenase Protein, Brucella abortus, Recombinant (His & Myc & SUMO) | Brucella abortus | E. coli |
Catalyzes the reversible oxidation of malate to oxaloacetate. | |||
TMPH-03136 | L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) | Plasmodium berghei | E. coli |
L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-00010 | LDHA Protein, Mouse, Recombinant (His) | Mouse | E. coli |
LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA, a key enzyme r... | |||
TMPY-02273 | 15-PGDH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in t... | |||
TMPH-02625 | DLAT Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | |||
TMPH-02867 | ASPDH Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. | |||
TMPY-00424 | HSD17B14 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPY-04568 | PDK1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantl... | |||
TMPH-00693 | L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His) | E. coli | E. coli |
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. | |||
TMPH-00553 | Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) | Erwinia citreus | E. coli |
Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) is expressed in E. coli. | |||
TMPY-02299 | ALDH3A1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (... | |||
TMPH-02626 | DLAT Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | |||
TMPH-01039 | CBR1 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction... | |||
TMPY-02446 | GAPDH Protein, Human, Recombinant (His) | Human | E. coli |
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate... | |||
TMPY-03433 | ALDH4A1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks... | |||
TMPY-01588 | ALDH7A1 Protein, Human, Recombinant (His) | Human | E. coli |
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol... | |||
TMPH-01225 | DHODH Protein, Human, Recombinant (His) | Human | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-01202 | D2HGDH Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-... | |||
TMPH-02850 | DHODH Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-03278 | DHODH Protein, Rat, Recombinant (His) | Rat | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPJ-00834 | ACADM Protein, Human, Recombinant (His) | Human | E. coli |
Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the m... | |||
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Cat No. | Product Name | ||
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L2550 | Glutamine Metabolism Compound Library | 580 compounds | |
A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ... |