dehydrogenase

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.

3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase.

Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

3-Hydroxybenzaldehyde is a compound useful in organic synthesis.

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.

Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.

Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

CM10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.

Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NADH. It can utilize both NAD+ and NADP+ as cofactors and serves in the regeneration of NADH and NADPH [1] [2].

Glutamate Dehydrogenase, Bovine Liver (EC 1.4.1.4), catalyzes the reversible oxidative deamination of glutamate, producing α-ketoglutarate and ammonia.

Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

Nitrofen is a selective contact herbicide that acts as an inhibitor of protoporphyrinogen oxidase and retinal dehydrogenase.

5,6-Dihydrouracil (5,6-Dihydrouracil) is an intermediate breakdown product of uracil.

Succinate dehydrogenase-IN-4 (Compound 4b) is an inhibitor of succinate dehydrogenase with an IC50 value of 3.38 μM. It exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare, with EC50 values of 16.33 μM and 18.06 μM, respectively.

D-Lactate dehydrogenase (D-LDH), an oxidoreductase, catalyzes the oxidation of D-lactate to pyruvate leveraging NAD+ or NADP+ as acceptors and acting on the donor CH-OH group. Predominantly found in bacteria and fungi, it is frequently utilized in biochemical research [1].

Aldehyde dehydrogenase NAD(P) (ALDH) is an enzyme that facilitates the conversion of aldehydes into their respective carboxylic acids while simultaneously reducing the cofactor NAD(P) to NAD(P)H, making it a key component in biochemical research. This enzyme plays a crucial role in mitigating aldehyde stress by being part of the body's array of enzymatic defenses [1].

Malate Dehydrogenase, Yeast (EC 1.1.1.37), is an enzyme in the citric acid cycle that catalyzes the conversion of malate to oxaloacetate, requiring NAD+. It plays a role in gluconeogenesis, the process of synthesizing glucose from small molecules.

Malic Dehydrogenase, Porcine (EC 1.1.1.37) exists in eukaryotic cells as two isoenzymes: one is expressed in the mitochondria and plays a role in the tricarboxylic acid cycle, while the other is expressed in the cytoplasm, converting malate back to oxaloacetate from the mitochondria.

L-Glutamic Dehydrogenase (NADP) from Proteus sp. (EC 1.4.1.4) catalyzes the conversion of glutamic acid to α-ketoglutaric acid.

Pyruvate Kinase/Lactic Dehydrogenase enzymes, Rabbit catalyze the ATP-dependent phosphorylation of glycolate to produce 2-phosphoglycolate. The activation of pyruvate kinase requires divalent cation Mg2+ and monovalent cation K+.