applications

KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].

Ibafloxacine (R835) is a fluoroquinolone antibiotic used exclusively in veterinary medicine and exhibits no bacteriostatic effect against Bartonella.

Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.

Rentiapril racemate (SA-446 racemate) is the racemic form of Rentiapril, exhibiting anti-inflammatory properties and potential applications in glaucoma research.

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.

Vialinin A (Terrestrin A), a p-terphenyl compound, exhibits antioxidant properties and acts as a potent inhibitor of TNF-α, USP4, USP5, and sentrin SUMO-specific protease 1 (SENP1). Its efficacy in autoimmune diseases and cancer research is noteworthy, highlighting its potential therapeutic applications.

MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.

BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor with an IC50 of 0.3 nM, exhibiting anti-tumor activity and potential applications in cancer and polycystic kidney disease research [1] [2].

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC, with potential applications in cardiac, proliferative, and neurodegenerative disease research.

SSR 180 is a potent and subtype-selective α7 agonist with applications in the study of Alzheimer;s disease and schizophrenia.

5,6-Diaminopyridine-3-carboxylic acid methyl ester (DAPME) has potential applications in anti-tumor, anti-inflammatory, antibacterial and other aspects.

Pyrazinamine is a synthetic intermediate that can be used in a variety of scientific research applications, including as a synthetic reagent and as a biochemical and physiological reagent.

3, 4-dihydro-2h-Pyrido [3,2-b][1,4]oxazine has potential applications in the study of bioactive compounds.

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose, occurring naturally and also produced synthetically from glucose. Formerly used as a diuretic, it may still be used as a laxative and in irrigating solutions for certain surgical procedures. It is also utilized in various manufacturing processes, as a pharmaceutical aid, and in several research applications.

4-Butoxyphenol (P-Butoxyphenol) is a phenolic compound with a wide range of applications in science and industry. It is often used in the synthesis of other compounds such as 4-butoxyphenylacetic acid and 4-butoxyphenylacetonitrile. It is also used in the synthesis of drugs such as ibuprofen and naproxen.

Iohexol is an X-ray contrast agent containing varying concentrations of iohexol, which can be used for a variety of imaging applications.

N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is an alkyl maltopyranoside detergent, particularly useful in transporters and respiratory complexes. It is a derivative of pyrene (Py) and has applications in the purification and stabilization of RNA polymerase, as well as the detection of protein-lipid interactions.

PLGA (poly(lactic-co-glycolic acid)) is be used to fabricate devices for drug delivery and tissue engineering applications.

Triethoxyoctylsilane (NSC 42964) is an organically modified silane that has been found to aggregate in the form of normal micelles as well as reverse micelles. Triethoxyoctylsilane (NSC 42964) is commonly used in plastic applications.

Sodium bicarbonate, also known as baking soda, is used in a wide range of applications in food, pharmaceuticals, cosmetics, etc. Sodium bicarbonate acts as a buffer, flavoring agent, disinfectant, pharmaceutical agent, and proton gradient modifier, and is often used as an antacid for the study of intestinal disorders.

Bupirimate (Nimrod), an active ingredient in plant protection products, is commonly used as a systemic fungicide and finds applications in controlling powdery mildew in roses, apple plantations. It belongs to the family of pyrimidines.

Potassium dihydrogen phosphate (Potassium phosphate monobasic), with a purity of ≥ 99%, is utilized as a buffering agent in molecular biology, biochemistry, and chromatography. It is employed in the preparation of biological buffers and is suitable for use in molecular biology applications.

λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system.

Protocatechualdehyde (3,4-Dihydroxybenzaldehyde), a natural polyphenol compound derived from radix Salviae Miltiorrhizae roots, exhibits diverse biological activities and finds extensive medicinal applications as an antioxidant, anti-aging, antibacterial, and anti-inflammatory agent.