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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9651 | PD-1/PD-L1-IN-9 | PD-1/PD-L1 | |
PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in... | |||
T9616 | PD-1/PD-L1-IN-10 | PD-1/PD-L1 | |
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy. | |||
T35394 | Sintilimab (anti-PD-1) | IBI308,Sintilimab (anti-PD-1) | PD-1/PD-L1 |
Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding to PD-1 and thereby blocking the interaction of PD-1 with i... | |||
T12379 | PD-1-IN-22 | Others , PD-1/PD-L1 | |
PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM). | |||
T3655 | BMS-1 | PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1 | Apoptosis , PD-1/PD-L1 |
BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene ... | |||
T40112 | PROTAC PD-1/PD-L1 degrader-1 | PROTAC PD-1/PD-L1 degrader-1 | |
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppr... | |||
T36900 | PD-1/PD-L1-IN-NP19 | PD-1/PD-L1-IN-NP19 | PD-1/PD-L1 |
PD-1/PD-L1-IN-NP19, a PD-1/PD-L1 inhibitor, exhibits an IC50 of 12.5 nM against the human PD-1/PD-L1 interaction, potentially activating the tumor immune microenvironment and contributing to its antitumor effects[1]. | |||
T36899 | INCB086550 | PD-1/PD-L1-IN-8 | PD-1/PD-L1 |
INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. | |||
T39904 | PD-1-IN-24 | ||
PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor. | |||
T36487 | Evixapodlin | PD-1/PD-L1-IN 7,GS-4224 | Antiviral , HBV , PD-1/PD-L1 |
Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities. | |||
T35396 | Spartalizumab (anti-PD-1) | PD-1/PD-L1 | |
Spartalizumab (anti-PD-1) is a useful organic compound for research related to life sciences and the catalog number is T35396. | |||
T12377 | PD-1-IN-17 | PD-1/PD-L1 | |
PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM. | |||
T12380 | PD-1/PD-L1-IN 5 TFA | PD-1/PD-L1-IN 5 | Others |
PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM). | |||
T5410 | PD158780 | EGFR | |
PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8μM, 49 nM, 52 nM, and 52 nM in cell assay). | |||
T4696 | BMS202 hydrochloride (1675203-84-5(free base)) | PD-1/PD-L1 inhibitor 2 hydrochloride | PD-1/PD-L1 |
BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L... | |||
T3146 | BMS-202 | PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2 | Apoptosis , PD-1/PD-L1 |
BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction. | |||
T12386 | PD-1-IN-18 | Others | |
PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator. | |||
T12378 | PD-1-IN-20 | Others | |
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1. | |||
T6932 | PD168393 | Apoptosis , EGFR , FGFR , IGF-1R , PDGFR , PKC , Autophagy | |
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin. | |||
T6136 | Canertinib | PD-183805,CI-1033 | EGFR |
Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp... |