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Ferfluor-1
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Catalog No. T219102 Copy Product Info
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Ferfluor-1 is a ferroptosis inhibitor with the ability to penetrate the blood-brain barrier, exhibiting an EC50 of 57 nM in HT108 cells, 75 nM in OS-RC-2 cells, and 2.3 nM in SH-SY5Y neuroblastoma cells. Additionally, it serves as a ratiometric photoluminescence probe and acts as a specific indicator of ferroptosis fluctuation. Ferfluor-1 has been shown to improve brain disorders associated with stroke and Parkinson's disease (PD) models.
Ferfluor-1
Cas No. 3030473-59-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ferfluor-1 is a ferroptosis inhibitor with the ability to penetrate the blood-brain barrier, exhibiting an EC50 of 57 nM in HT108 cells, 75 nM in OS-RC-2 cells, and 2.3 nM in SH-SY5Y neuroblastoma cells. Additionally, it serves as a ratiometric photoluminescence probe and acts as a specific indicator of ferroptosis fluctuation. Ferfluor-1 has been shown to improve brain disorders associated with stroke and Parkinson's disease (PD) models. |
| In vitro | Ferfluor-1 effectively inhibits ferroptosis in HT1080 fibrosarcoma cells, OS-RC-2 renal cancer cells, and SH-SY5Y neuroblastoma cells, with EC50 values of 57 nM, 75 nM, and 2.3 nM, respectively. At a concentration of 5 μM, Ferfluor-1 does not inhibit staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. |
| In vivo | Ferfluor-1 (10 mg/kg; intravenous injection) effectively alleviates ischemic brain injury in MCAO mice by inhibiting ferroptosis, as evidenced by reduced infarct volume, improved cerebral blood flow, and decreased levels of lipid peroxidation and ferroptosis markers. |
| Molecular Weight | 288.41 |
| Formula | C15H20N4S |
| Cas No. | 3030473-59-4 |
| Smiles | N=1N=C(SC1C=2C=CC(NC3CCCCC3)=C(N)C2)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Ferfluor-1 in vivo | Ferfluor-1 in vitro | Ferfluor-1 formula | Ferfluor-1 molecular weight
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