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Flavonoids
Flavonoids are a group of plant metabolites thought to provide health benefits through cell signalling pathways and antioxidant effects. These molecules are found in a variety of fruits and vegetables. Flavonoids are abundant in plants, in which they perform several functions. The abundance of flavonoids coupled with their low toxicity relative to other plant compounds means they can be ingested in large quantities by animals, including humans. Examples of foods that are rich in flavonoids include onions, parsley, blueberries, bananas, dark chocolate and red wine. Flavonoids are important antioxidants, and promote several health effects. Aside from antioxidant activity, these molecules provide the following beneficial effects: anti-viral; anti-cancer; anti-inflammatory; anti-allergic.
- (Iso)-Isomucronulatol 7-O-glucosideT384894367-43-8Isomucronulatol 7-O-glucoside is a biologically active isoflavone isolated from Astragalus membranaceus.
- $81
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- AsebogeninTN3460520-42-3Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli.
- $653
SizeQTY - Sanggenon CT4S161580651-76-91. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.
- $97
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Cited - PROCYANIDIN C1TN210337064-30-5Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
- $72
SizeQTY Cited - KurarinoneT5S099334981-26-5Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response.
- $39
SizeQTY - GlycitinT282040246-10-4Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.
- $60
SizeQTY - Vincetoxicoside BTN111322007-72-3Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.
- $45
SizeQTY - DaidzeinT1238486-66-8Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
- $45
SizeQTY Cited - Medroxyprogesterone AcetateT126171-58-9Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
- $30
SizeQTY Cited - Epimedin AT3906110623-72-8Epimedin A has anti-osteoporosis activities in vivo.
- $130
SizeQTY Cited - SophoricosideT3233152-95-4Sophoricoside (Genistein sophoricoside) is effective against inflammation and can reduce the GPT.
- $34
SizeQTY Cited - DiosminT0878520-27-4Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.
- $45
SizeQTY - 6-MethoxyflavanoneTN31743034-04-66-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuropathic pain.
- $40
SizeQTY - DihydrodaidzeinTN158017238-05-0Dihydrodaidzein ((±)-Dihydrodaidzein)-producing bacteria might lead to clarification of some of the mechanisms regulating the production of equol by fecal microbiota.
- $82
SizeQTY - (±)-CatechinT82557295-85-4(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
- $42
SizeQTY Cited - MyricetinT0579529-44-2Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has antioxidant properties.
- $30
SizeQTY Cited - NaringeninT2838480-41-1Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
- $50
SizeQTY Cited - SpinosinT6S222772063-39-91. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of Spinosin. 2. Spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABAA and 5-HT1A receptors. 3. There was a wide brain regional tissue distribution of Spinosin. The concentrations of Spinosin in corpus striatum and hippocampus were higher than that in other areas.
- $90
SizeQTY - GenistinT2882529-59-9Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities
- $60
SizeQTY - IridinT3820491-74-7Iridin (Lridin) is major active ingredient of Iris dichotoma which could be used as the drug for pain, inflammation treatment
- $80
SizeQTY - CasanthranolT07718024-48-4Casanthranol is a concentrated mixture of anthranol glycosides derived from the dried bark of Rhamnus p., commonly known as cascara sagrada. This compound serves as a stimulant laxative that is primarily administered to alleviate constipation and other medical conditions. By exerting its effects on the intestinal wall, casanthranol promotes increased muscle contractions, thereby facilitating bowel movements.
- $41
SizeQTY - FarrerolT6S052524211-30-11. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3. Farrerol inactivates KEAP-1 or act
- $110
SizeQTY - FormononetinT0724485-72-3Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.
- $45
SizeQTY Cited - QuercetinT2174117-39-5Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
- $42
SizeQTY Cited - 3,7,4'-TrihydroxyflavoneTN21432034-65-33,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-κB ligand (RANKL) receptor activators.
- $81
SizeQTY - DidyminT378714259-47-3Didymin (Neoponcirin) has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.
- $67
SizeQTY Cited - (-)-Epicatechin gallateT27321257-08-5(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.
- $50
SizeQTY Cited - Methyl-HesperidinT022811013-97-1Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
- $50
SizeQTY - OrientinT6S072128608-75-51. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. 3. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.
- $29
SizeQTY Cited - TangeretinT2842481-53-8Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notch-1 inhibitor.
- $47
SizeQTY - AmentoflavoneT34171617-53-4Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
- $30
SizeQTY Cited - (±)-TaxifolinT4008024198-97-8(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark, with anti-tyrosinase and anti-fibrotic activity.Taxifolin is an inhibitor of collagenase, with an IC 50 value of 193.3 μM. Taxifolin is a free radical scavenger with antioxidant capacity.
- $29
SizeQTY - ISOGINKGETINT4S21320548-19-61. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg/kg ip for 3d) can reduce the level of O2·- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.
- $48
SizeQTY Cited - Icariside IT380856725-99-6Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.
- $120
SizeQTY Cited - KaempferolT2177520-18-3Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
- $46
SizeQTY Cited - Quercetin DihydrateT66306151-25-3Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects.
- $46
SizeQTY Cited - (±)-NaringeninTMS217167604-48-2(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- $45
SizeQTY Cited - GenisteinT1737446-72-0Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.
- $38
SizeQTY Cited - GinkgetinT4S2126481-46-91. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead
- $120
SizeQTY Cited - SilibininT166022888-70-6Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
- $50
SizeQTY Cited - IcariinT2855489-32-7Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
- $33
SizeQTY Cited - TaxifolinT1738480-18-2Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
- $46
SizeQTY Cited - (-)-EpicatechinT2856490-46-0(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
- $53
SizeQTY Cited - MyricitrinT275717912-87-7Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
- $50
SizeQTY Cited - 4'-MethoxyflavanoneTN305097005-76-04'-Methoxyflavanone is a flavonoid isolated from natural Isaria fumosorosea KCH J2, which is used in the study of metabolic and cardiovascular diseases.
- $110
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- (2R)-6-MethoxynaringeninTN3176L1212075-61-0In house(2R)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one is one of the potentially active components in Scutellaria baicalensis.
- $195
SizeQTY - Alpinumisoflavone acetateTN339686989-18-6Alpinumisoflavone acetate (4'-O-Acetylalpinumisoflavone) is a new alpinumisoflavone derivative. Alpinumisoflavone strongly inhibits germ tube growth at 0.63 ug/disc.
- $165
SizeQTY - PseudobaptigeninTN723390-29-9Pseudobaptigenin (Psi-baptigenin) is an isoflavone, a flavonoid lipid molecule that is a natural product found in Pterocarpus marsupium, Dalbergia spruceana.
- $171
SizeQTY - Ro 09-0680T2855187112-49-0In houseRo 09-0680, a compound derived from Salvia miltiorrhiza, is a potent inhibitor of collagen-induced platelet aggregation in rabbits with potential anti-inflammatory activity for the study of cardiovascular disease.
- $293
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