oxide

7α-Hydroxycholesterol, a cholesterol oxide formed through both enzymatic and non-enzymatic oxidation, can serve as a biomarker for lipid peroxidation.

BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-β/Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.

Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

Nicotinic acid N-oxide (Nicotinic acid 1-oxide) is a nicotinic acid derivative, used to treat hyperlipoidemia.

Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.

Diphenyl oxide (Oxydibenzene) is used in the manufacture of spices and dyes.

4-Methylmorpholine N-oxide is often used as a co-oxidant and sacrificial catalyst in oxidation reactions.

Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

4-Nitroquinoline 1-oxide (4-NQO) is a chemical carcinogen that induces mutations in bacteria, fungi, and animals through the formation of large amounts of purine adducts.

Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.

Nickel(II) oxide is the chemical compound with the formula NiO. It is the principal oxide of nickel.

Alpha-Pinene oxide is the oxidised form and endogenous metabolite of alpha-pinene, used in biochemical experiments and drug synthesis research.

Isophorone Oxide is an organic compound with a unique structure, and is used in biochemical experiments and drug synthesis research.

Rose oxide is a pyran derivative widely used in biochemical experiments and drug synthesis research.

3-Methylpyridine 1-oxide is a pyridine derivative widely used in biochemical experiments and drug synthesis research.

Compound 791-28-6, with CAS No. 791-28-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 791-28-6 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Safrole oxide was found to significantly inhibit neuronal cell growth and induce apoptosis. Safrole oxide elevated the levels of cyclooxygenase 2 (COX-2), interleukin-8 (IL-8) and reactive oxygen species (ROS), which was accompanied by nuclear factor-kappa B (NF-κB) nuclear translocation during the transdifferentiation, suggesting safrole oxide may induce endothelial cell transdifferentiation into functional neuron-like cells.

Dasatinib N-oxide is a minor metabolite of Dasatinib.Dasatinib is an orally potent inhibitor of Src/Bcr-Abl.

Sinomenine N-oxide is one of the major metabolites of the cyclic metabolic mechanism of Sinomenine.

7-OXIDE-7-AZAINDOLE, with CAS No. 55052-24-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-OXIDE-7-AZAINDOLE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Afatinib N-Oxide, an impurity resulting from the oxidative degradation of Afatinib, is an irreversible inhibitor of the EGFR (Epidermal Growth Factor Receptor) family.

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium-labeled Brexpiprazole S-oxide, the primary metabolite of Brexpiprazole, which is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).