| T2384 |
PomalidomideHOT |
Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
|
| T1642 |
LenalidomideHOT |
Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
|
| T1847 |
Necrostatin-1HOT |
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
|
| T9072 |
BDTX-189 |
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
|
| TN1235 |
3,4,5-Tricaffeoylquinic acid |
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like re...
|
| TN1475 |
Caulophyllogenin |
Caulophyllogenin in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α±, and for prevention and treatment of inflammat...
|
| TN1407 |
Artocarpin |
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
|
| TN1403 |
Arjunolic acid |
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
|
| TN1373 |
Alpha-caryophyllene |
Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects,...
|
| TN1362 |
Afzelin |
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protec...
|
| TN1359 |
Aflatoxin G1 |
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
|
| TN1354 |
Aaptamine |
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
|
| TN1295 |
5-O-Caffeoylshikimic acid |
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
|
| TN1291 |
5-Hydroxy-3',4',7-trimethoxyflavone |
5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC val...
|
| TN1242 |
3,8-Di-O-methylellagic acid |
3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a ...
|
| TN1228 |
25S-Inokosterone |
25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
|
| TN1232 |
(2R)-5,7-Dimethoxyflavanone |
5,7-Dimethoxyflavanone has anti-inflammatory activity.
|
| TN1511 |
Cleomiscosin A |
Cleomiscosin A has antioxidant activity, it could be beneficial in preventing LDL oxidation in atherosclerotic lesions, it shows inhibitory activity to TNF-α± ...
|
| TN1227 |
25R-Inokosterone |
25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
|
| TN1212 |
2-Hydroxyeupatolide |
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and ...
|
| TN1132 |
Procyanidin A2 |
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2...
|
| TN1088 |
3,3',4',5,6,7,8-heptamethoxyflavone |
3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective...
|
| TN1086 |
Dehydroeburicoic acid |
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
|
| TN1077 |
Taraxerol |
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
|
| TN1055 |
Licochalcone E |
Licochalcone E is a potential LXRβ agonist.
|
| TN1019 |
Beta-mangostin |
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
|
| T7795 |
RIPA-56 |
RIPA-56 is an inhibitor of RIP1
|
| TN1507 |
Clematichinenoside AR |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associa...
|
| TN1599 |
Eburicoic acid |
Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme ...
|
| TN1543 |
Cynaropicrin |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential a...
|
| TN1960 |
Mussaenoside |
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
|
| TN2178 |
Sanggenone H |
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
|
| TN2149 |
Reynosin |
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
|
| TN2102 |
Procurcumenol |
Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release of tumor necrosis factor-a (TNF-a).
|
| TN2082 |
Pinostrobin |
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiti...
|
| TN2079 |
(-)-Pinoresinol |
Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulati...
|
| TN2064 |
Physcion 8-O-beta-D-monoglucoside |
Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α±-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.
|
| TN2010 |
Ombuin |
Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process.
|
| TN1996 |
Nothofagin |
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
|
| TN1983 |
Neoisoastilbin |
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
|
| TN1981 |
Neocurdione |
Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a protective effect against D-GalN/tumor necr...
|
| TN1953 |
Morusinol |
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
|
| TN1579 |
Dihydrocucurbitacin B |
Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of ...
|
| TN1936 |
Mogroside IIIe |
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
|
| TN1933 |
Mitraphylline |
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
|
| TN1890 |
Lupeol acetate |
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
|
| TN1882 |
Lucidenic acid D2 |
Lucidenic acid D2 is a nartural product from G. lucidum AF.
|
| TN1803 |
Isoscoparin |
Isoscoparin has antioxidant, and anti-adipogenic effects, it may be a potential therapeutic agent for the prevention and treatment of obesity. Isoscoparin can si...
|
| TN1793 |
Isorhamnetin 3-O-galactoside |
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
|
| TN1764 |
Incensole acetate |
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
|
| TN1742 |
Homovanillyl alcohol |
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Ho...
|
| TN1731 |
Hernandezine |
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
|
| TN1681 |
Gentianine |
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
|
| TQ0181 |
Resatorvid |
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
|
| T7151 |
GSK2982772 |
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
|
| T7091 |
N-Formyl-Met-Leu-Phe |
N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).
|
| TQ0181 |
Resatorvid |
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
|
| T6204 |
QNZ |
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
|
| T3805 |
Cimifugin beta-D-glucopyranoside |
Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
|
| T6591 |
ML130 |
Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
|
| T3790 |
Hederacoside D |
Hederacoside D is a bioactive saponins from Hedera helix.
|
| T2993 |
Cordycepin |
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
|
| T2367 |
SKF86002 |
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
|
| T2205 |
Theophylline-7-acetic acid |
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
|
| T1813 |
VGX1027 |
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
|
| T2932 |
Ginsenoside Rh1 |
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
|
| T0875 |
Acetylcysteine |
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
|
| T1265 |
Amrinone |
Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
|
| T0213 |
Thalidomide |
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic ...
|
| T4450 |
GIBH130 |
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
|
| T0131 |
Cepharanthine |
Cepharanthine, a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet ag...
|
| T1738 |
Taxifolin |
Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
|
| T0122 |
Bengenin |
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
|
| T2048 |
LY364947 |
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
|
| T0429 |
Glucosamine |
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
|
| T2794 |
Astilbin |
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
|
| T3332 |
Isosteviol |
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
|
| T3561 |
CPI1189 |
REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
|
| T6852 |
GSK481 |
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
|
| T2065 |
Bioymifi |
Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
|
| T3537 |
GSK583 |
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
|
| T3280 |
Disodium clodronate tetrahydrate |
Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
|
| T4074 |
GSK872 |
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
|
| T7397 |
GSK547 |
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
|
| T4S0998 |
Trifolirhizin |
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...
|
| TN2197 |
Secoisolariciresinol |
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
|
| T6815 |
HS1371 |
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
|
| T5779 |
MOSLOFLAVONE |
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
|
| T5788 |
XYLOBIOSE |
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
|
| T5785 |
MALTOTETRAOSE |
MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression o...
|
| T5768 |
Bruceine B |
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysacchar...
|
| T5660 |
Menthone |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
|
| T5054 |
GSK963 (Racemate) |
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
|
| T4S0217 |
HOMOPLANTAGININ |
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
|
| T2S0731 |
Trilobatin |
Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
|
| T3S1641 |
Esculentoside H |
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
|
| T3997 |
WEHI345 |
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
|
| T5S1632 |
8-O-Acetylshanzhiside methyl ester |
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
|
| T4637 |
R7050 |
R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
|
| T2A2481 |
Taurochenodeoxycholic Acid |
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
|
| T5S2129 |
Sciadopitysin |
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
|
| T6S2099 |
Geraniin |
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Gerani...
|
| T6S0653 |
Linarin |
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver ...
|
| T5S0167 |
Atractylenolide I |
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reducti...
|
| T2S2264 |
Linalool |
1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was p...
|
| T2S0843 |
Negletein |
1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the acti...
|
| T4412 |
Roquinimex |
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces t...
|
| T4319 |
Hispidol |
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with a...
|
| TN2180 |
Sappanchalcone |
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
|
| TN2224 |
Soyasapogenol A |
Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma T...
|
| T9057 |
Norbergenin |
Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
|
| TN4171 |
Grossamide |
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
|
| TN4418 |
Lasiodiplodin |
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron tran...
|
| TN4409 |
Lansiumarin C |
Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
|
| TN4392 |
Koaburaside |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have...
|
| TN4374 |
Kaerophyllin |
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
|
| TN4334 |
Isotaxiresinol |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activa...
|
| TN4303 |
Isokaempferide |
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
|
| TN4243 |
Hyuganin D |
Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.
|
| TMA1777 |
Hydrangenol 8-O-glucoside |
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
|
| TN4194 |
Heliangin |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
|
| TN4190 |
Hedycoronen A |
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
|
| TN4164 |
Grandifloroside |
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, s...
|
| TN4429 |
Leucodin |
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
|
| TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
|
| TN4146 |
Glutinol acetate |
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17...
|
| TN4093 |
Galeopsin |
Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines...
|
| TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
|
| TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
|
| TN4013 |
Esculentic acid |
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
|
| TMA2576 |
Episappanol |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis f...
|
| TN3914 |
Echinatine |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and...
|
| TN3849 |
Dihydrodehydrodiconiferyl alcohol |
Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines. It may be useful candidates for developing therapeutic agents for ...
|
| TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
|
| TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
|
| TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
|
| TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
|
| TN3741 |
Cyclocurcumin |
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
|
| TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
|
| T4074L |
GSK872 HCl（1346546-69-7 free base） |
GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
|
| T8845 |
UTL-5g |
UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hema...
|
| T8692 |
(Rac)-Benpyrine |
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
|
| TN5278 |
Zederone |
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
|
| TN5264 |
Xanthoxyletin |
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
|
| TN5238 |
Viscidulin II |
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β prod...
|
| TN5164 |
Trans-Hinokiresinol |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
|
| TN5147 |
Tilifodiolide |
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
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| TN5138 |
Teuclatriol |
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
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| TMA0627 |
Taxiresinol |
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
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| TN5019 |
Siegeskaurolic acid |
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
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| TN4986 |
Selinidin |
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
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| TN4490 |
Manassantin B |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
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| TN4938 |
Samidin |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
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| TN4879 |
Questinol |
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
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| TN4776 |
Physalin D |
Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 m...
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| TN4679 |
Nudiposide |
Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in...
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| TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
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| TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
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| TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
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| TN4592 |
Murrangatin |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
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| TN4583 |
Moringin |
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of exper...
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| TN4581 |
Moracin D |
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
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| TN4561 |
Methylnissolin |
Methylnissolin is a natural product from A. membranaceus.
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| TN3779 |
De-O-methyllasiodiplodin |
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
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| TN3708 |
Coronarin D |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
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| TN2243 |
Sugiol |
Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals....
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| T11501 |
GSK840 |
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
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| T4S1057 |
Tripdiolide |
Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
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| T3S0006 |
Methyl ferulate |
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
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| T2S1040 |
Jolkinolide B |
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
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| T2S0606 |
Bakkenolide A |
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
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| T2S0501 |
Ilexgenin A |
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
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| T16755 |
RIPK-IN-4 |
RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
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| T11742 |
K-7174 |
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
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| T19250 |
CRIPGBM |
cRIPGBM is a proapoptotic derivative of RIPGBM and a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to RIPK2 (EC50: 68 nM in...
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| T13951 |
UCB-9260 |
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
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| T13175 |
TNF-α-IN-1 |
TNF-α-IN-1 is an inhibitor of TNF-α.
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| T11484 |
GSK2593074A |
GSK2593074A is a necroptosis inhibitor for dual-targeting to both RIP1 and RIP3.
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| T5S0993 |
Kurarinone |
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
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| T11474 |
GSK-843 |
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor ( IC50: 8.6 nM for binding RIP3 kinase domain; IC50: 6.5 nM for inhibiting kinase ac...
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| T11442 |
GNE684 |
GNE684 is a potent inhibitor of receptor-interacting protein 1 (RIP1; (mean Kiapps: 21 nM, 189 nM, and 691 nM for human, mouse, and rat RIP1).
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| T10730 |
CDC801 |
CDC801 is a potent and orally active inhibitor of PDE4 and TNF-α (IC50: 1.1 μM and 2.5 μM).
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| T15437 |
GSK3145095 |
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
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| T10350 |
Apremilast D5 |
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rel...
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| T12730 |
RIPK1-IN-4 |
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
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| T14312 |
Apratastat |
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) a...
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| T12202 |
Nec-4 |
Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
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| T8440 |
LASSBio-1135 |
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
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| TN2309 |
Withanolide A |
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
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| TN2259 |
Taurocholic acid |
Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver; taurocholic acid feeding prevents tumor necr...
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| T5S0313 |
Liquiritin apioside |
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells again...
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| TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
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| TN3692 |
Conduritol A |
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant abilit...
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| TN3452 |
Arteannuin M |
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
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| TMA1409 |
Cis-Mulberroside A |
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
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| TN3655 |
Cimiside E |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
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| TN3635 |
Chlojaponilactone B |
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
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| TN3614 |
Cearoin |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
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| TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
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| TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
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| TN3541 |
Broussonin E |
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
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| TN3537 |
Braylin |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
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| TN3517 |
Bisacurone |
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
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| TN3495 |
Benzyl ferulate |
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
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| TN3453 |
Arteannuin N |
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
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| TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
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| TN2539 |
1beta-Hydroxyalantolactone |
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
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| TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
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| TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol |
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
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| TN3298 |
8alpha-Hydroxyhirsutinolide |
8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
|
| TN3245 |
7-O-Methylmorroniside |
7-O-Methylmorroniside exhibits anti-inflammatory activity.
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| TN3219 |
7,8-Didehydrocimigenol |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
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| TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone |
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
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| TN3119 |
5-Hydroxy-7,8-dimethoxyflavanone |
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
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| TN2974 |
3-O-Methylquercetin tetraacetate |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
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| TN2895 |
3,5-Dicaffeoyl-epi-quinic acid |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
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| TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
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| TN2588 |
11-Hydroxytephrosin |
11-Hydroxytephrosin inhibits NF-kappaB activity.
|
| T0694 |
Pranlukast |
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
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