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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. Product name CAS No. Purity Chemical Structure
TN3614 Cearoin 52811-37-7 98%
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN4561 Methylnissolin 733-40-4 98%
Methylnissolin is a natural product from A. membranaceus.
TN1228 25S-Inokosterone 19595-18-7 98%
25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
T13175 TNF-α-IN-1 444287-49-4 98%
TNF-α-IN-1 is an inhibitor of TNF-α.
TN4592 Murrangatin 37126-91-3 98%
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN2974 3-O-Methylquercetin tetraacetate 1486-69-7 98%
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
TN3453 Arteannuin N 207446-92-2 98%
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN2539 1beta-Hydroxyalantolactone 68776-47-6 98%
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
TMA0627 Taxiresinol 40951-69-7 98%
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
TN1077 Taraxerol 127-22-0 98%
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
TN2149 Reynosin 28254-53-7 98%
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
TN3245 7-O-Methylmorroniside 119943-46-3 98%
7-O-Methylmorroniside exhibits anti-inflammatory activity.
TN5147 Tilifodiolide 126724-95-6 98%
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
TN1960 Mussaenoside 64421-27-8 98%
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN5019 Siegeskaurolic acid 52645-97-3 98%
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TN4164 Grandifloroside 61186-24-1 98%
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, sug...
TN3325 9-O-Feruloyl-5,5'-dimethoxylariciresinol 166322-14-1 98%
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN4986 Selinidin 19427-82-8 98%
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Cearoin
TN3614
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Methylnissolin
TN4561
Methylnissolin is a natural product from A. membranaceus.
25S-Inokosterone
TN1228
25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
TNF-α-IN-1
T13175
TNF-α-IN-1 is an inhibitor of TNF-α.
Murrangatin
TN4592
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
3-O-Methylquercetin tetraacetate
TN2974
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
Arteannuin N
TN3453
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
1beta-Hydroxyalantolactone
TN2539
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
Taxiresinol
TMA0627
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
Taraxerol
TN1077
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
Reynosin
TN2149
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
7-O-Methylmorroniside
TN3245
7-O-Methylmorroniside exhibits anti-inflammatory activity.
Tilifodiolide
TN5147
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
Mussaenoside
TN1960
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
Siegeskaurolic acid
TN5019
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Grandifloroside
TN4164
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, sug...
9-O-Feruloyl-5,5'-dimethoxylariciresinol
TN3325
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
Selinidin
TN4986
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
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