TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN3614	Cearoin	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN4561	Methylnissolin	733-40-4	98%
TN4561	Methylnissolin is a natural product from A. membranaceus.
TN1228	25S-Inokosterone	19595-18-7	98%
TN1228	25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
T13175	TNF-α-IN-1	444287-49-4	98%
T13175	TNF-α-IN-1 is an inhibitor of TNF-α.
TN4592	Murrangatin	37126-91-3	98%
TN4592	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN2974	3-O-Methylquercetin tetraacetate	1486-69-7	98%
TN2974	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
TN3453	Arteannuin N	207446-92-2	98%
TN3453	Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN2539	1beta-Hydroxyalantolactone	68776-47-6	98%
TN2539	1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
TMA0627	Taxiresinol	40951-69-7	98%
TMA0627	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
TN1077	Taraxerol	127-22-0	98%
TN1077	Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
TN2149	Reynosin	28254-53-7	98%
TN2149	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
TN3245	7-O-Methylmorroniside	119943-46-3	98%
TN3245	7-O-Methylmorroniside exhibits anti-inflammatory activity.
TN5147	Tilifodiolide	126724-95-6	98%
TN5147	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
TN4635	Neoechinulin A	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
TN1960	Mussaenoside	64421-27-8	98%
TN1960	Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN5019	Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN4164	Grandifloroside	61186-24-1	98%
TN4164	Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, sug...
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol	166322-14-1	98%
TN3325	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN4986	Selinidin	19427-82-8	98%
TN4986	Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.