syndrome — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72107	Werner syndrome RecQ helicase-IN-1		DNA/RNA Synthesis
	Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.		DNA/RNA Synthesis
T72108	Werner syndrome RecQ helicase-IN-2
	Werner syndrome RecQ helicase-IN-2 (example 57), a potent inhibitor of the Werner syndrome RecQ DNA helicase enzyme (WRN), holds potential for use in cancer research.
T72109	Werner syndrome RecQ helicase-IN-3
	Werner syndrome RecQ helicase-IN-3, a potent and orally active inhibitor of Werner syndrome RecQ helicase (WRN), exhibits anticancer and antiproliferative activities with an IC50 value of 0.06 µM.
T72110	Werner syndrome RecQ helicase-IN-4
	Werner syndrome RecQ helicase-IN-4 is a potent, orally active inhibitor of Werner syndrome RecQ helicase (WRN) with an IC50 of 0.06 µM, exhibiting both antiproliferative and anticancer activities.
T80964	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) acts as a T cell proliferation activator by promoting the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner and is utilized...
T9420	Prifinium bromide		Others
	Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.		Others
T9778	KCNQ1 activator-1		Potassium Channel
	2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies.		Potassium Channel
T1460	Dicyclomine hydrochloride		AChR
	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.		AChR
T8452	Dantrolene		Others
	Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.		Others
T5491	GSK3179106		c-RET
	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM		c-RET
T19723	AMTB hydrochloride	AMTB	TRP/TRPV Channel
	AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...		TRP/TRPV Channel
T7656	Apelin-13
	Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...
T4277	Osilodrostat	LCI699	Glucocorticoid Receptor , Others , Hydroxylase
	Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).		Glucocorticoid Receptor , Others , Hydroxylase
T0680	Lamotrigine	LTG,BW430C	5-HT Receptor , Sodium Channel , Autophagy
	Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		5-HT Receptor , Sodium Channel , Autophagy
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T7780	Blarcamesine	AE-37,AVex-73	AChR
	Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.		AChR
T1308	Orphenadrine hydrochloride	Mebedrol,Mephenamin	Sodium Channel , NMDAR , Norepinephrine , iGluR , Histamine Receptor
	Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T6574	Lumiracoxib	Prexige,COX-189	COX
	Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.		COX
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor