4′‐br

m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC) for Trastuzumab, positioned distally from the monomethyl auristatin E (MMAE) payload to produce an ADC with modified hydrophilicity, antigen binding, and in vitro potency[1].

Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Thalidomide-4-Br,7-F is an E3 ligase activator that contains both a bromine and a fluorine atom. E3 ligases are proteins that tag other proteins with ubiquitin to facilitate their degradation via proteolysis. The two halogens can be substituted for further derivatization.

Boc-NH-C4-Br is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

cis-4-Br-2,5-F2-PCPA (S1024) inhibits LSD1 and LSD2 with Ki values of 94 nM and 8.4 μM, respectively. It inhibits LSD1 cell proliferation and increases dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells, particularly where there is aberrant expression of LSD1 in cancer stem cells [1].

Boc-D-Phe(4-Br)-OH is an amino acid derivative and has a wide range of applications in life science related research.

Boc-Phe(4-Br)-OH, an amino acid derivative, has a wide range of applications in life science research.

Fmoc-D-Phe(4-Br)-OH, an amino acid derivative, has numerous applications in life science research.

Fmoc-Phe(4-Br)-OH, an amino acid derivative, has a wide range of applications in life science research.

4-Br-Bnlm, with an EC 50 of 0.96 µM, acts as a selective inhibitor of glucose-regulated protein 94 (Grp94). It effectively reduces both mutant and wild-type misfolded myocilin proteins in cells, thereby enhancing the clearance of toxic forms of myocilin and diminishing myocilin toxicity [1] [2].

(1R,3S,4aS,4bR,7S,10aS)-7-[(1R)-1,2-dihydroxyethyl]-3-hydroxy-1,4a,7-trimethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2R,4aR,4bR,10aS)-8-{[(2S,3R,4S,5S)-4,5-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-11-hydroxy-4a,4b,7,7,10a-pentamethyl-2-(3-methyl-4-oxo-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}pentyl)-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11-hexadecahydrochrysene-2-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2R,4aS,4bR,8S,10aR)-1-acetyl-8-{[(2S,3R,4S,5S)-5-hydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2-(3-hydroxybutyl)-4a,4b,7,7,10a-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11-hexadecahydrochrysene-2-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2Z)-5-[(1S,2S,4bR,7R,10aR)-7-[(2-carboxyacetyl)oxy]-2-hydroxy-2,4b,8,8,10a-pentamethyl-tetradecahydrophenanthren-1-yl]-3-methylpent-2-enoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-[(2S,4bR,7S)-7-{[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,4b-dimethyl-2-(prop-1-yn-1-yl)-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthren-1-yl]acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-[(2S,4bR,7S)-7-{[(2R,3R,4S,5S,6R)-4-hydroxy-6-(hydroxymethyl)-3,5-bis({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy})oxan-2-yl]oxy}-2,4b-dimethyl-2-(prop-1-yn-1-yl)-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthren-1-yl]acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl (4aR,4bR,10aR,12aS)-6,10-dihydroxy-3,4b,7,7,10a,12a-hexamethyl-12-methylidene-1,4,5,8-tetraoxo-1H,3H,4H,4aH,4bH,5H,7H,8H,9H,10H,10aH,10bH,11H,12H,12aH-phenanthro[2,1-c]pyran-4a-carboxylate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl (4bR,10aR,12aS)-6-hydroxy-3,4b,7,7,10a,12a-hexamethyl-12-methylidene-1,4,5,8-tetraoxo-1H,3H,4H,4aH,4bH,5H,7H,8H,10aH,10bH,11H,12H,12aH-phenanthro[2,1-c]pyran-4a-carboxylate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl (4aR,4bR,5R,6R,10aR,12aS)-5,6-bis(acetyloxy)-2,4b,7,7,10a,12a-hexamethyl-12-methylidene-1,4,8-trioxo-hexadecahydro-1H-phenanthro[1,2-c]pyran-2-carboxylate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

Pomalidomide-C2-amide-C4-Br is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate) comprising a Pomalidomide-based Cereblon (CRBN) ligand and one linker unit. This compound is utilized in the synthesis of PROTACs.

Thalidomide-NH-amido-C4-Br is a coupling of an E3 ligase ligand and linker, utilized in the synthesis of the PROTAC degrader BSJ-02-162.

(S,R,S)-AHPC-Me-amide-C4-Br contains a VHL ligand of the E3 ubiquitin ligase and a PROTAC linker. This compound can be utilized in the design of PROTACs, such as PROTACERK5 degrader-1.

(1S,4aS,4bR,6aS,10aS)-2-acetyl-1-(2-carboxyethyl)-1,4a,4b,9,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a-tetradecahydrochrysene-6a-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1R,4aR,4bR,7S,8aS)-7-ethenyl-1-(hydroxymethyl)-1,4b,7-trimethyl-1,2,3,4,4a,4b,5,6,7,8,8a,9-dodecahydrophenanthren-9-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.