GHR

GHR (Growth Hormone Receptor) is a cell surface receptor primarily responsible for mediating the biological effects of growth hormone (GH). By binding to GHR, GH activates the JAK2-STAT5 signalling pathway, promoting cell proliferation, differentiation, and metabolic regulation. In the liver, GHR activation stimulates the synthesis and secretion of insulin-like growth factor 1 (IGF-1), thereby influencing systemic growth and metabolism. Dysfunction of GHR is associated with various disorders, including growth hormone deficiency and acromegaly, making it a crucial target for studying growth development and metabolic regulation.