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TargetMol | Tags Metabolism
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PGK1

PGK1 (Phosphoglycerate kinase 1) is the first key metabolic enzyme in the production of ATP during glycolysis and is involved in the glycolytic pathway in tumors, and is capable of influencing tumor growth, migration, invasion, gene expression, energy metabolism, and molecular regulation, and is therefore associated with a variety of diseases, such as cancers, neurodegenerative disorders, and cardiovascular diseases.

FilterHomeSignaling PathwaysMetabolismPGK1
CBR-470-1
T400632416095-06-0
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protects SH-SY5Y neuronal cells from MPP+-induced cytotoxicity by activating the Keap1-Nrf2 cascade. cytotoxicity induced by MPP+.
  • $35
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Acriflavine Hydrochloride
T198328063-24-9
Acriflavine Hydrochloride (Acriflavine HCl) is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in vivo.
  • $41
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Z57346765
T876591016340-64-9
Z57346765 is a specific PGK1(Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.
  • $48
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