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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(52)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(40)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(119)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(53)

Stearoyl-CoA Desaturase (SCD)

Transketolase

Transketolase is a thiamine diphosphate (ThDP)-dependent enzyme that plays a crucial role in the pentose phosphate pathway and the reductive pentose phosphate cycle of photosynthesis. There are three isoforms of transketolase: TKT, TKTL1, and TKTL2. Its activity requires the participation of thiamine diphosphate and divalent cations (Mg2+, Ca2+, etc.).

Filter HomeSignaling PathwaysMetabolismTransketolase

Oxythiamine

T12354136-16-3

Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor. Oxythiamine inhibits cancer cell proliferation and induces cell cycle arrest. Oxythiamine has potential anticancer activity, inhibits non-oxidative synthesis of ribose, and induces apoptosis.

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Transketolase-IN-4

T72576419547-73-2

Transketolase-IN-4 is a transketolase inhibitor with an IC50 value of 3.9 μM.Transketolase-IN-4 inhibited Mycobacterium tuberculosis DXS with an IC50 value of 114.1 μM. Transketolase-IN-4 inhibited the SW620, LS174T, and MIA PaCa-2 tumor cell proliferation.

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TKL-IN-1

T205736

TKL-IN-1 (compound 7r) serves as an inhibitor of transketolase (Transketolase) and can be utilized as an herbicide. This compound effectively hampers the growth of Digitaria sanguinalis (Ds) and Amaranthus retroflexus (Ar).

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N3PT

T1215813860-66-7

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

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Benfooxythiamine

T204625909542-99-0

Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.