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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(103)

Glyoxalase

(18)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(108)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(294)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(2)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(105)

Stearoyl-CoA Desaturase (SCD)

Transketolase

Transketolase is a thiamine diphosphate (ThDP)-dependent enzyme that plays a crucial role in the pentose phosphate pathway and the reductive pentose phosphate cycle of photosynthesis. There are three isoforms of transketolase: TKT, TKTL1, and TKTL2. Its activity requires the participation of thiamine diphosphate and divalent cations (Mg2+, Ca2+, etc.).

Filter HomeSignaling PathwaysMetabolismTransketolase

Oxythiamine

Hydroxythiamin

T12354136-16-3

Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor. Oxythiamine inhibits cancer cell proliferation and induces cell cycle arrest. Oxythiamine has potential anticancer activity, inhibits non-oxidative synthesis of ribose, and induces apoptosis.

Apoptosis Endogenous Metabolite Transketolase

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Transketolase-IN-4

T72576419547-73-2

Transketolase-IN-4 is a transketolase inhibitor with an IC50 value of 3.9 μM.Transketolase-IN-4 inhibited Mycobacterium tuberculosis DXS with an IC50 value of 114.1 μM. Transketolase-IN-4 inhibited the SW620, LS174T, and MIA PaCa-2 tumor cell proliferation.

Antibacterial Transketolase

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Transketolase-IN-2

T725572757552-21-7

Transketolase-IN-2 is a potent inhibitor of Transketolase, demonstrating significant inhibitory effects on Digitaria sanguinalis and Amaranthus retroflexus, with over 90% inhibition at 200 mg/L and approximately 80% at 100 mg/L. This compound is relevant for research in weed control.

Others Transketolase

$1,520

6-8 weeks

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Herbicidal agent 6

T200613

Herbicidal agent 6 (D15) functions as a Transketolase (TKL) inhibitor and exhibits herbicidal activity.

Others Transketolase

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Oxythiamine diphosphate ammonium

T64282

Oxythiamin diphosphate ammonium [OxyThDP, OxiTDP] is a potent inhibitor of transketolase (TK).

Others Transketolase

$1,500

10-14 weeks

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TKL-IN-1

T205736

TKL-IN-1 (compound 7r) serves as an inhibitor of transketolase (Transketolase) and can be utilized as an herbicide. This compound effectively hampers the growth of Digitaria sanguinalis (Ds) and Amaranthus retroflexus (Ar).

Transketolase

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Transketolase-IN-3

T749812757552-03-5

Transketolase-IN-3, a potent inhibitor of transketolase (TK), exhibits herbicidal activity by effectively suppressing Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). This compound holds potential for herbicide research applications [1].

Others Transketolase

$1,520

4-6 weeks

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N3PT

N3-pyridyl thiamine

T1215813860-66-7

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

Others Transketolase

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Benfooxythiamine

T204625909542-99-0

Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.

SARS-CoV Transketolase

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10-14 weeks

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α-Glycerophosphate Dehydrogenase-Triosephosphate

GDH-TPI, GDH-TIM

TRP-00343

α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TIM). This compound is employed to measure transketolase (TK) activity in erythrocyte hemolysates, which helps in assessing vitamin B deficiency.

Transketolase

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Transketolase-IN-5

T209242

Transketolase-IN-5 (compound 6ba) is an inhibitor of transketolase. It exhibits herbicidal activity against Amaranthus retroflexus, Setaria viridis, and Digitaria sanguinalis.

Transketolase

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Transketolase-IN-6

T209243

Transketolase-IN-6 (Compound 6bj) serves as a lead compound for herbicides. It achieves approximately 80% root inhibition in redroot pigweed (Amaranthus retroflexus) and green foxtail (Setaria viridis). Moreover, Transketolase-IN-6 is an effective inhibitor of transketolase (TK).

Transketolase